Health food for regulating blood fat and preventing liver against chemical damage and its prepn
A technology for chemical liver injury and health food, applied to medical preparations containing active ingredients, digestive system, medical raw materials derived from ginkgo biloba, etc. Problems such as high production costs, to achieve significant effects, cost reduction, and low cost
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preparation example Construction
[0016] The preparation method of chitosan oligosaccharide (referring to Chinese patent, application number: 00110009.2) is as follows:
[0017] (1) Prepare chitosan oligosaccharide by enzymatically degrading chitosan; (chitosan can be obtained by deacetylation of chitin (shrimp, crab shell, etc.))
[0018] (2) Using hollow fiber or flat plate ultrafilter combined with degradation reaction to separate active oligosaccharides in situ in real time;
[0019] (3) Filter the ultrafiltrate with a nanofilter again to separate high-concentration active chitosan oligosaccharides.
[0020] The enzyme degradation process can be that 0.5-3.0% by weight chitosan is dissolved in acetic acid solution, and the degradation enzyme is chitinase, cellulase, bromelain, lysozyme, lipase, chitosanase, or Its complex, the amount of enzyme relative to chitosan is 0.5-3.0% by weight; the reaction temperature is 15-60°C, and the pH is 3.0-7.0; Pump the enzymolysis solution from the reaction kettle into...
Embodiment 1
[0030] The following operations are all carried out under 300,000-level GMP conditions.
[0031] 1). At room temperature, grind schisandra, kudzu root and auxiliary materials cassia, ginkgo biloba, mountain jasmine, milk thistle and / or licorice through a 60, 80 or 100 mesh sieve, mix them in a blender according to the proportion, dry and pulverize to obtain Chinese medicine powder;
[0032] 2). Mix the chitosan oligosaccharide and traditional Chinese medicine powder prepared by the above method in a blender according to a certain ratio, and dry and sterilize for 2 hours at 50, 65, 85 or 100°C;
[0033] The preparation weight ratio can be:
[0034] Chitooligosaccharide 10%; Schisandra 70%, Pueraria 20%;
[0035] Oligochitosan 20%; Schisandra 35%, Pueraria 15%; Shanxi 15%, Licorice 15%;
[0036] Chitooligosaccharide 30%; Schisandra 40%, Pueraria 25%; Ginkgo biloba 5%;
[0037] Chitooligosaccharide 50%; Schisandra 10%, Pueraria 40%;
[0038] Chitooligosaccharide 60%; Schisan...
Embodiment 2
[0043] dosage
[0044] After oral administration of different doses of the present invention to rats for 29 days, the body weight dose group can significantly reduce rat serum total cholesterol (TC) levels, which is significantly different from that of the matched group; the body weight dose group can significantly reduce rat serum triglycerides (TG) level, compared with the control group, there is a significant difference; there is a certain role in auxiliary regulation of blood lipids.
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