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Medicine for treating osteomyelitis and preparation thereof

A technology for osteomyelitis and medicine, which is applied in the preparation of the medicine and the field of medicine for treating osteomyelitis, can solve the problems such as few experimental research reports, and achieve the effect of simple administration method, good biocompatibility and high safety

Inactive Publication Date: 2008-08-06
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, few experimental studies have been reported

Method used

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  • Medicine for treating osteomyelitis and preparation thereof
  • Medicine for treating osteomyelitis and preparation thereof
  • Medicine for treating osteomyelitis and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Solvent suspension volatilization method to prepare polysebacic anhydride, polylactic acid blended ofloxacin sustained-release tablets

[0038] There are two main methods of preparing polymer material sustained-release tablets: melting-dispersion method and solvent evaporation method (Gao Bo, Luge, Su Tongfang. A biodegradable drug controlled release system implanted into the brain for the treatment of brain tumors[J].Pharmaceutical Progress .2000;24:274). The melting and dispersing method is to heat the polymer to the melting point to make it appear in a molten state, add solid powdered drug according to the required drug loading ratio and stir well, then pour it into a preheated mold, cool it at room temperature, and process it into the required product. size and shape. The solvent evaporation method is to dissolve the polymer material and the loading drug in a certain co-soluble solvent, pour it into the mold at a low temperature, and then further process ...

Embodiment 2

[0048] Example 2 In vitro drug release experiment of polysebacic anhydride, polylactic acid blended ofloxacin sustained-release tablets

[0049] Sampling: Take 3 tablets of polysebacic anhydride and polylactic acid with ratios of 5:95, 10:90, 15:85, 20:80, 25:75 and 30:70w / w, respectively, and place them in test tubes. 10ml of 0.1M phosphate buffer (pH 7.4) was added to each solution, and the mixture was kept in a constant temperature water bath at 37°C. The phosphate buffer solution was replaced at 2 hours, 5 hours, and 10 hours after the experiment started; the phosphate buffer solution was replaced once a day from the 1st to 14th day of the experiment, and then every 2 days from the 15th to 28th day; Phosphate buffer was changed every 3 days for 58 days, and then every 7 days until 3 months after release. After the liquid was taken out and centrifuged, the supernatant liquid was taken and sealed in a test tube, and stored at -20°C until testing.

[0050] Preparation of st...

Embodiment 3

[0060] Example 3 In vitro bacteriostatic experiment of polysebacic anhydride, polylactic acid blended ofloxacin sustained-release tablets

[0061] Take 9 tablets of ofloxacin sustained-release tablets blended with polysebacic anhydride and polylactic acid, each 3 tablets as a group, and place them in the agarose inoculated with Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa respectively. In the center of the culture medium (only one piece is placed in a petri dish), measure the size of the inhibition zone after culturing at 37°C for 24 hours. Then transfer the tablet into a new medium to measure the inhibition zone every 3 days, and replace the new medium, repeating this until 2 months after the experiment, and then replace the new medium every week until 3 months after the experiment. Another tablet of polysebacic anhydride and polylactic acid blend without ofloxacin and of the same size, shape and blending ratio was placed in the above bacterial culture ...

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Abstract

A medicine in the form of tablet for treating osteomyelitis is prepared through shearing polylactic acid, dissolving in tetrahydrofuran solution while heating, dissolving polydecanedioic acid anhydride powder in it, stirring, grinding while adding ofloxacin powder to attach the mixture on the inner surface of container and gradually drying it, baking for volatilizing tetrahydrofuran, collecting the dried mixture, shearing, loading in die, hot pressing, cooling in water, and demoulding.

Description

technical field [0001] The invention relates to the field of orthopedics, more specifically to a medicine for treating osteomyelitis, and also to a preparation method of the medicine, which is suitable for preventing and treating acute and chronic osteomyelitis. Background technique [0002] Acute hematogenous osteomyelitis and osteomyelitis caused by open fracture infection are common clinical and frequently-occurring diseases. When the treatment measures are improper or the treatment is difficult to be effective, the inflammation will become chronic. Once it develops into chronic osteomyelitis, systemic application of antibiotics is often difficult to form an effective antibacterial concentration locally, and prolonged intravenous administration will increase the systemic side effects of antibiotics. Therefore, the development of local slow-release or slow-release technology of antibiotics can improve local treatment efficacy and reduce systemic adverse reactions, open up ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/495A61K47/34A61K9/20A61P19/08A61K31/5383
Inventor 陈廖斌汪晖王钧傅杰
Owner WUHAN UNIV
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