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Method for preparing magnetic Nano composite granules coated by cationic polyelectrolyte

A technology of magnetic nanoparticles and cationic polymerization, which is applied in the field of preparation in the field of nanotechnology, can solve the problems that the magnetic particles cannot be uniformly coated, the magnetic particles cannot be uniformly dispersed, and the dispersion system cannot be obtained, and achieves wide application value. , Conducive to the effect of adsorption and uniform dispersion

Active Publication Date: 2009-04-08
江苏纳菲生物医药科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, lauric acid cannot really disperse the magnetic particles evenly in water, and actually obtain large agglomerates with a diameter of more than 200nm
Cationic polyelectrolytes are only coated on the surface of these aggregates, and it is impossible to coat each magnetic particle uniformly
At the same time, the aggregates modified by cationic polyelectrolytes will settle under the action of gravity due to their too large diameter, and cannot obtain a stable dispersion system.

Method used

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  • Method for preparing magnetic Nano composite granules coated by cationic polyelectrolyte

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 2.4 grams of ferric chloride hexahydrate and 1.68 grams of ferrous sulfate heptahydrate are dissolved in 10 milliliters of water. Then slowly add 5 milliliters of ammoniacal liquor (25%) dropwise under stirring to produce black precipitate rapidly. After the ammoniacal liquor is added dropwise, The temperature of the reaction system was raised to 80° C., and the reaction was carried out under stirring and nitrogen protection for 1 hour. Then the product was washed with deionized water to neutrality to obtain ferric oxide particles with an average particle diameter of 10 nm, and its surface zeta potential in water was as shown in the accompanying drawing. Add the freshly prepared water-carrying particles into 80 ml of water, then add 1.6 g of citric acid monohydrate, stir for 5 minutes, and disperse with ultrasound for 20 minutes under ice water cooling. The pH of the product is adjusted to between 6.8 and 7.2 with 0.5 mol per liter of sodium hydroxide solution to obtain...

Embodiment 2

[0022] According to the method described in Example 1, the difference is that 2.5 g of oxalic acid is used instead of 1.6 g of citric acid monohydrate. Add oxalic acid, stir for 5 minutes, and disperse by ultrasonic for 40 minutes under ice water cooling. Subsequent steps are the same as in Example 1.

[0023] As a result, a water-based dispersion liquid was also prepared, containing 6-10 mg / ml of polyethyleneimine-coated magnetic nano-ferric oxide particles.

Embodiment 3

[0025] 12 grams of ferric chloride hexahydrate and 8.4 grams of ferrous sulfate heptahydrate are dissolved in 50 milliliters of water. Then slowly add 25 milliliters of ammoniacal liquor (25%) dropwise under stirring, and black precipitate is produced rapidly, after the ammoniacal liquor is added dropwise, The temperature of the reaction system was raised to 80° C., and the reaction was carried out under stirring and nitrogen protection for 1 hour. Then the product was washed with deionized water until neutral to obtain ferric oxide particles with an average particle diameter of 10 nanometers. After the particles were freeze-dried, 1 g was taken out and added to 20 ml of water, and then 2 g of acetic acid was quickly added, stirred for 5 minutes, and then dispersed by ultrasound for 40 minutes under ice water cooling. The pH of the product is adjusted to between 6.8 and 7.2 with 0.1 mole per liter of sodium hydroxide solution to obtain a stable ferriferric oxide dispersion. T...

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Abstract

This invention discloses a method for preparing cationic polyelectrolyte-coated magnetic nanoparticles. The method comprises: (1) preparing magnetic nanoparticles, adding into carboxylic compound solution, ultrasonically dispersing, and adjusting to neutrality with standard NaOH solution to obtain stable magnetic solution; (2) dialyzing to remove small molecular impurities, and mixing with cationic polyelectrolyte solution to obtain cationic polyelectrolyte-coated magnetic nanoparticles. The method is suitable for ferrite magnetic nanoparticles on any nanometer scale and water-soluble cationic polyelectrolyte. The obtained composite magnetic nanoparticles can be stably dispersed in water for a long time, and can be used for biomass separation, targeted drug delivery, and gene delivery and transfection.

Description

technical field [0001] The invention relates to a preparation method in the field of nanotechnology, in particular to a preparation method for cationic polyelectrolyte-coated magnetic nanocomposite particles. Background technique [0002] As a new type of material with many important application values ​​in the fields of biology and medicine, the application research of magnetic nanoparticles has developed rapidly in recent years. Studies have found that magnetic nanoparticles have unique application properties in magnetic resonance imaging (MRI) imaging, tumor hyperthermia, targeted drug delivery, biomolecules or cell separation. The latest research also found that using nano-magnetic particles as a carrier can achieve efficient and safe gene delivery and expression. The application ability of nanoparticles depends to a large extent on the means and techniques of their surface modification. For example, as a contrast agent for long-term circulation in the body, nano-magne...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01G49/02C01G49/08C01G49/06C04B35/628A61K47/00A61K49/06A61P35/00C12N15/63
Inventor 古宏晨王晓亮
Owner 江苏纳菲生物医药科技有限公司
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