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Modified natural polymer medical adjuvant, its preparation method and use

A technology of natural polymers and pharmaceutical excipients, applied in the field of modified natural polymer pharmaceutical excipients and their preparation and application, to achieve the effects of increasing swelling, increasing disintegration ability, and accelerating moisture absorption speed

Inactive Publication Date: 2009-06-24
HUBEI HUILIAN FILM COATING TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are certain limitations in its application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: add the distilled water of 2 times of the quality of the polysaccharide in 20g of the polysaccharide, after stirring evenly, add the sodium hydroxide of 5% of the quality of the polysaccharide, stir at room temperature, basify for 40 minutes, add 20% of the quality of the polysaccharide Chloroacetic acid, etherification reaction at 75°C for 8 hours, then use 1mol / L dilute sulfuric acid to neutralize the reaction product to a pH value of 5-6, filter, wash 3 times with 80% (mass fraction) ethanol, Drying at 50°C yielded an average molecular weight of 20.2×10 4 、-CH 2 Carboxymethylpachyran 1 with a COOH substitution degree of 0.162.

Embodiment 2

[0036] Embodiment 2: add the distilled water of 3 times of the quality of the polysaccharide in 20g pachymansin, after stirring evenly, add the swelling inhibitor sodium sulfate of 0.5% of the quality of the polysaccharide as the quality of the polysaccharide as the polysaccharide, add the quality of the polysaccharide as the distilled water 3% sodium hydroxide, stirred at room temperature, basified for 60 minutes, added 15% chloroacetic acid of the quality of polysaccharides, etherified at 50°C for 10 hours, and then used 1mol / L dilute sulfuric acid to dilute the reaction product and to a pH value of 5 to 7, filtered, washed 3 times with 80% (mass fraction) ethanol, dried at 50°C to obtain an average molecular weight of 22.2×10 4 、-CH 2 Carboxymethylpachyran 2 with a COOH substitution degree of 0.179.

Embodiment 3

[0037] Embodiment 3: add the distilled water of 5 times of the quality of the polysaccharide in 20g polysaccharide, after stirring evenly, add the sodium hydroxide of 3% of the quality of the polysaccharide, stir at room temperature, basify for 60 minutes, add 15% of the quality of the polysaccharide Chloroacetic acid was etherified at 50°C for 10 hours, and then the reaction product was neutralized to a pH of 5 to 7 with 1 mol / L dilute sulfuric acid, filtered, and washed 3 times with 80% (mass fraction) ethanol, Drying at 50°C yielded an average molecular weight of 22.2×10 4 、-CH 2 Carboxymethylpachyran 3 with a COOH substitution degree of 0.216.

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Abstract

The invention relates to modified natural macromolecule pharmaceutical auxiliary materials carboxymethyl pachyranan and hydroxypropyl pachyranan. The preparation method is to disperse the polysaccharide in water or ethanol to alkalinize it, and then carry out etherification reaction. The pharmaceutical adjuvant carboxymethyl pachyranan and hydroxypropyl pachyranan prepared by the present invention can not only be used as a disintegrating agent for tablets, but also can be beneficial to compression molding, which improves the performance of tablets due to their excellent cohesive properties and swelling properties. Appearance, improved tablet quality. It has strong adaptability, especially tablets that are not easy to form, such as tablets with strong plasticity, brittleness, and strong evacuation performance. After adding this product, it will have an improvement effect. The compressed tablet has better hardness, especially the loose tablet and the tablet with pried lid. After adding this product, it is not only easy to shape, but also has a good appearance. The tablet is smooth and glossy. The carboxymethylpachylan and hydroxypropylpachylan prepared by the invention are suitable for disintegrating agents of tablets and have broad development prospects.

Description

technical field [0001] The invention relates to a modified natural polymer pharmaceutical auxiliary material and a preparation method and use thereof. Background technique [0002] Pharmaceutical excipients are the material basis for the existence of pharmaceutical preparations and the necessary materials for the production of pharmaceutical preparations. Therefore, all countries in the world attach great importance to the development of new pharmaceutical excipients. [0003] Tablets are the most widely used oral solid preparations. To improve the quality of tablets, choosing good excipients is the key. Fillers and disintegrants are the most important excipients in ordinary tablets, and the selection of these excipients directly affects the internal quality of the tablet and the curative effect of the drug. At present, the commonly used auxiliary materials mainly include starch, cellulose, alginic acid, clay, PVP, gum and so on. [0004] With the development of pharmaceut...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61K9/20
Inventor 胡先明肖玉玲梁淑彩邱国福
Owner HUBEI HUILIAN FILM COATING TECH