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Medicine composition for treating diseases relating to gastric acid

A drug and gastric acid technology, applied in the direction of drug combination, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of maximum blood drug concentration, peak time AUC difference, poor absorption, etc. , to achieve the effect of increasing stability and slowing down degradation

Inactive Publication Date: 2007-07-25
GUANGDONG HUANAN PHARMACEUTICAL GROUP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Typical benzimidazole-based proton pump sustained-release preparations are poorly absorbed after single-dose administration, and the maximum plasma concentration, time to peak, and AUC vary greatly among individuals

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment one, pantoprazole tablet

[0030] prescription:

[0031] Pantoprazole 40g

[0032] Calcium glycerophosphate 150g

[0033] Sodium bicarbonate 450g

[0034] Carboxymethyl Starch Sodium 20g

[0035] Magnesium Stearate 6g

[0036] The preparation process is as follows: successively mix the carboxymethyl starch sodium, calcium glycerophosphate, sodium bicarbonate, magnesium stearate, and pantoprazole in the prescribed amount, and finally directly compress the mixed material to make 1000 tablets, each containing 40 mg pantoprazole.

Embodiment 2

[0037] Embodiment two, rabeprazole sodium capsule

[0038] prescription:

[0039] Rabeprazole Sodium 10g

[0040]Sodium bicarbonate 550g

[0041] Sodium carboxymethyl starch 20g

[0042] Magnesium Stearate 6g

[0043] The preparation process is as follows: mix the sodium bicarbonate, sodium carboxymethyl starch, magnesium stearate, and rabeprazole sodium in the prescribed amount evenly, and then fill the mixture into capsules to make 1000 capsules, each containing 10mg rabeprazole sodium.

Embodiment 3

[0044] Embodiment three, lansoprazole powder

[0045] prescription:

[0046] Lansoprazole 15g

[0047] Sodium bicarbonate 900g

[0048] Xylitol 100g

[0049] Lactose 100g

[0050] The preparation process is as follows: the sodium bicarbonate, xylitol, lactose, and lansoprazole are mixed evenly in the prescription amount, and then the mixed material is divided into 1000 small bags, and each bag contains 15 mg of lansoprazole.

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PUM

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Abstract

A composite medicine for treating the diseases associated with gastric acid contains the benzimidazole-type proton pump depressant, the buffer material for neutralizing acid and improving the stability of said proton pump depressant and pharmacologically acceptable assistants.

Description

technical field [0001] The invention relates to a drug combination preparation for treating gastric acid-related diseases, in particular to a drug for treating gastric acid-related diseases comprising effective therapeutic doses of benzimidazole proton pump inhibitors and buffer substances and pharmaceutically acceptable auxiliary materials combination. Background technique [0002] Peptic ulcer refers to chronic ulcers that occur in the stomach and duodenum. In terms of epidemiology, peptic ulcer is a common disease, and its incidence rate varies greatly in different periods and regions. 10-20% of the population. The pathogenesis of peptic ulcer is currently believed to be due to the enhancement of attack factors such as gastric acid, pepsin, Helicobacter pylori (Hp), and gastrin, and the weakening of defense factors such as mucosal barrier, mucosal blood flow, mucosal repair, and prostaglandins. Since the late 1980s, the advent of new acid suppressant proton pump inhibit...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/4439A61K9/14A61K9/16A61K9/20A61K9/46A61K9/48A61K47/32A61K47/34A61K47/36A61K47/38A61K47/42A61P1/04A61P1/14A61K31/191A61K31/198A61K31/4172A61K31/732A61K33/00A61K33/08A61K33/10A61K33/12A61K33/42A61K47/10
Inventor 龙超峰谢称石王金超
Owner GUANGDONG HUANAN PHARMACEUTICAL GROUP CO LTD
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