Magnetic target medicine sustained and controlled release carrier material and preparation method and application thereof

A controlled-release carrier and magnetic targeting technology, which is applied in drug delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of weak magnetic response, low orientation efficiency, drug loading and encapsulation efficiency of single magnetic particles. Incompletely controllable and other issues, to achieve the effect of high magnetic response strength

Inactive Publication Date: 2007-11-28
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these two types of materials have some defects in application, such as incomplete controllability of drug loading and encapsulation efficiency, weak magnetic response of single magnetic particles leading to low orientation efficiency

Method used

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  • Magnetic target medicine sustained and controlled release carrier material and preparation method and application thereof
  • Magnetic target medicine sustained and controlled release carrier material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] step 1)

[0041] Get 2ml of polystyrene (PS) emulsion (average particle diameter 230nm) with a concentration of 80mg / ml and disperse it in 250ml deionized water, add FeCl 2 aqueous solution, Fe in the system 2+ The concentration is 0.02mol / L, after ultrasonic dispersion for several minutes, add 0.0015mol hexamethylenetetramine (HMTA) under stirring, pH=11, raise the temperature to 70~80℃ for 3h, then separate the product with a magnetic field, use Wash the product with ionic water for 3 to 5 times, dry the product at 60°C for 24 hours, and the product is Fe 3 o 4 Nanoparticle-coated magnetic composite spheres of polymer microspheres.

[0042] Step 2)

[0043] The product obtained in step 1) was placed in a muffle furnace, protected by nitrogen, and slowly heated to 500° C. at a heating rate of 10° C. / min. It was calcined for 3 hours and then taken out.

[0044] step 3)

[0045] A polyelectrolyte solution was prepared by dissolving poly(allylamine hydrochloride, PA...

Embodiment 2

[0052] Replace the polystyrene microspheres in embodiment 1 step 1) with 800nm ​​polystyrene microspheres, replace the solution A in embodiment 1 step 3) with the acetic acid solution of 10mg / ml chitosan, use 10mg / ml PAA aqueous solution Instead of solution B in step 3) of Example 1, the deionized water in step 3) of Example 1 was replaced with acetic acid / sodium acetate standard buffer solution with pH=3.6, and steps 1-4 of Example 1 were repeated for others. Finally, magnetic composite hollow spheres coated with 4 double-layer polyelectrolyte multilayer films were obtained.

[0053] The drug release performance evaluation method is the same as that in Example 1, and the results show that the drug release rate increases with the increase of the pH value of the system, and the release rate in the pH=9.0 medium is close to twice that in the pH=2.0 medium.

Embodiment 3

[0055] Replace the polystyrene microsphere in embodiment 1 step 1) with the polymethyl methacrylate microsphere of average diameter 400nm, use Zn(Ac) 2 and FeCl 2 The mixed solution replaces embodiment 1 step 1) FeCl 2 solution, Zn in the system 2+ The concentration is 0.01mol / L, Fe 2+ with Zn 2+ The molar ratio is 2: 1, replace the hexamethylenetetramine in embodiment 1 step 1) with NaOH, system pH=13, other reaction conditions are the same as embodiment step 1), gained product is Zn ferrite nanoparticle A magnetic composite ball coated with polymer microspheres; then repeat steps 2 to 4 in Example 1). Finally, magnetic composite hollow spheres coated with 6 double-layer polyelectrolyte multilayer films were obtained.

[0056] The drug release performance evaluation method is the same as in Example 1, and the results show that in release media of different pH values, the system has shown a sustained release behavior to drug molecules, and the release rate of the drug var...

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Abstract

The present invention relates to magnetically targeting controlled medicine releasing carrier material and its preparation process and use. The magnetically targeting controlled medicine releasing carrier material consists of one inside magnetic hollow microsphere and several film layers of biocompatible polyelectrolyte to form the shell. It is prepared with the magnetic hollow microsphere as template and through a layer-by-layer adsorption process to deposit the film layers of biocompatible polyelectrolyte. The hollow microsphere serves as the medicine container, while the polymer film layers control the release rate of the medicine under different outer conditions. The present invention has great medicine carrying capacity, ability of controlled release of medicine in different organism tissues, and outer magnetic field orientating and biological targeting functions.

Description

technical field [0001] The present invention relates to a carrier material for drug targeted release and a preparation process thereof, in particular to a magnetically targeted drug sustained and controlled release carrier material of double-shell drug-loaded hollow microspheres coated with a polyelectrolyte multilayer film and magnetic hollow microspheres, and the The preparation method and application of the sustained and controlled release carrier material for magnetically targeted drugs. Background technique [0002] For a long time, one of the most important problems in the drug treatment system is that due to the systemic diffusion of the drug and the lack of selectivity to the lesion site, the high concentration and large dose of the drug required to achieve a specific therapeutic effect increase the therapeutic effect. Cost, non-selective toxicity and other side effects caused by high drug dose also have a great impact on the therapeutic effect. The targeted drug sy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02A61K47/34A61K9/00A61K9/14A61K9/48A61K47/32
Inventor 唐芳琼张彦奇李琳琳任俊张琳
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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