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Total-fibroin albumen composite material and preparation method thereof

A technology of silk fibroin and composite materials, which is applied in the fields of textile fiber processing and protein chemistry, and can solve problems such as the inability to obtain high-concentration silk fibroin aqueous solution, the final degradation and recycling of unfavorable materials, and the limited size of silk fibroin membrane materials. , to achieve the effects of easy cell adhesion, improved interfacial compatibility, and easy biodegradability

Inactive Publication Date: 2008-06-25
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the above-mentioned reports, since no effective method for concentrating the silk fibroin solution has been found, a high-concentration, high-molecular-weight silk fibroin aqueous solution cannot be obtained, and the film-forming of the matrix is ​​improved by adding epoxy resin and cross-linking. property, which is not conducive to the final degradation and recycling of the material and its application in the biomedical field
On the other hand, as the cooked fabric of the reinforcing layer, due to sticking, even if a triazine coupling agent is used, the improvement of fiber wettability is still limited, and at the same time, the resulting silk fibroin film is limited in material size.

Method used

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  • Total-fibroin albumen composite material and preparation method thereof
  • Total-fibroin albumen composite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Silkworm cocoons arranged in one direction were treated with 0.5% sodium bicarbonate solution at 98° C. for 60 minutes. After rinsing with deionized water, it was flow-dried to constant weight at room temperature, and the mass of the silk fiber was weighed. The degummed silk was treated with 6mol / L lithium bromide solution for 10 minutes, and then quickly washed with water to completely remove the residual lithium bromide on the surface. Then, under the condition of 4°C, with the regenerated silk fibroin solution with a concentration of 15.6% as the matrix, soak the pretreated silk for 24 hours, defoam and let it stand, and finally cast it into a film at room temperature. Control the content of silk fiber in the final composite material to be 25%. The tensile strength of the obtained composite material extending along the long axis of the fiber is 151±5MPa, the elongation at break is 27.1±1.4%, and the Young's modulus is 2.8±0.1GPa.

Embodiment 2

[0020] Example 2: The unidirectionally arranged silkworm cocoons were treated with 0.5% sodium carbonate solution at 105° C. for 30 minutes and repeated twice. After rinsing with deionized water, it was flow-dried to constant weight at room temperature, and the mass of the silk fiber was weighed. The degummed silk was treated with 8mol / L lithium bromide solution for 1 hour, and then quickly washed with water to completely remove the residual lithium bromide on the surface. Then, under the condition of 4°C, with the regenerated silk fibroin solution with a concentration of 13.3% as the matrix, the pretreated silk was soaked for 24 hours, defoamed and left standing, and finally casted at room temperature to form a film. Control the content of silk fiber in the final composite material to be 10%. The tensile strength of the obtained composite material along the long axis of the fiber is 64±4MPa, the elongation at break is 6.4±1.4%, and the Young's modulus is 2.9±0.2GPa.

Embodiment 3

[0021] Example 3: The unidirectionally arranged silk cocoons were treated with 0.5% sodium bicarbonate solution at 100° C. for 60 minutes. After rinsing with deionized water, it was flow-dried to constant weight at room temperature, and the mass of the silk fiber was weighed. The degummed silk was treated with 4mol / L guanidine hydrochloride solution for 30 minutes, and then quickly washed with water to completely remove residual guanidine hydrochloride on the surface. Then, under the condition of 4°C, with the regenerated silk fibroin solution with a concentration of 14.6% as the matrix, the pretreated silk was soaked for 24 hours, defoamed and left standing, and finally casted at room temperature to form a film. Control the content of silk fiber in the final composite material to be 20%. The tensile strength of the obtained composite material along the long axis of the fiber is 137±8MPa, the elongation at break is 21.7±2.4%, and the Young's modulus is 2.7±0.2GPa.

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Abstract

The invention pertains to the field of textile fiber processing and chemical technology of protein, in particular to a whole silk fibroin protein composite and a preparation method thereof. The invention adopts inorganic salt solution to preprocess degummed silk of directional arrangement which is taken as a reinforced layer, and then adopts concentrated regenerated silk fibroin aqueous solution to cast the degummed silk to form film, thus obtaining a whole silk fibroin protein composite with high performance. The whole silk fibroin protein composite has further optimized mechanical property after being processed by alcoholic solvents. Both the substrate and fiber phase of the composite are originated from fibroin protein, with good biocompatibility, are easy adhesive for cells and are biodegradable. Therefore, the composite has extensive application prospect in the field of medicine.

Description

technical field [0001] The invention belongs to the technical fields of textile fiber processing and protein chemistry, and in particular relates to a high-performance whole silk fibroin composite material and a preparation method thereof. Background technique [0002] At present, with the gradual enhancement of social environmental awareness and the increasing shortage of petroleum resources, green chemistry and the industrial revolution it brings have become a trend. It is one of the research hotspots to use natural fibers instead of traditional synthetic fibers (such as glass fibers) to reinforce thermoplastic or thermosetting resins and prepare environmentally friendly composite materials. Due to the advantages of wide sources, small specific gravity, renewable, degradable, and reliable mechanical properties, natural fibers have been gradually used in various fields such as aviation, aerospace, automobiles, sports equipment, packaging, and daily necessities. Natural fib...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L89/00C08J5/18
Inventor 邵正中袁青青陈新
Owner FUDAN UNIV
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