Method for preparing 3,7-di(2,4-dinitrophenoxy)-2-naphthoic acid
A technology of dinitrophenoxy, naphthoic acid, applied in 3 fields, achieves the effects of simple operation, convenient source, high yield and purity
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Embodiment 1
[0028] 20.4 grams (0.10 moles) of 3,7-dihydroxynaphthalene-2-carboxylic acid, 44.6 grams (0.22 moles) of 2,4-dinitrochlorobenzene, 110.4 grams (0.80 moles) of potassium carbonate, 700 milliliters of N,N - Put dimethylformamide and 180 ml of toluene into the reaction kettle, stir, heat and reflux for water separation for 18 hours, concentrate the reaction solution, recover the solvent for recycling, cool the reactant system, add water, precipitate a solid product, filter, Soak in 10% dilute acetic acid aqueous solution, filter, wash with hot water 2 to 3 times, dry to obtain 51.8 grams of 3,7-bis(2,4-dinitrophenoxy)-2-naphthoic acid crystal product, purity It is 99.3%. According to the actual amount of 3,7-bis(2,4-dinitrophenoxy)-2-naphthoic acid and the theoretical amount (53.6 grams), 3,7-bis(2,4 The yield of -dinitrophenoxy)-2-naphthoic acid was 96.7%.
Embodiment 2
[0030] 20.4 grams (0.10 moles) of 3,7-dihydroxynaphthalene-2-carboxylic acid, 54.4 grams (0.22 moles) of 2,4-dinitrobromobenzene, 55.2 grams (0.40 moles) of potassium carbonate, 150 milliliters of N,N - Put dimethylacetamide and 15 ml of xylene into the reaction kettle, stir, heat and reflux for water separation for 3 hours, concentrate the reaction solution, recover the solvent for recycling, cool the reactant system, add water, precipitate a solid product, filter , soaked in 0.1% dilute hydrochloric acid aqueous solution, filtered, washed with hot water for 2 to 3 times, dried to obtain 41.0 grams of 3,7-bis(2,4-dinitrophenoxy)-2-naphthoic acid crystal product, purity 99.0%, according to the actual amount of 3,7-bis(2,4-dinitrophenoxy)-2-naphthoic acid and the theoretical amount (53.6 grams), calculate 3,7-bis(2,4 The yield of -dinitrophenoxy)-2-naphthoic acid was 76.5%.
Embodiment 3
[0032] 20.4 grams (0.10 moles) of 3,7-dihydroxynaphthalene-2-carboxylic acid, 40.5 grams (0.20 moles) of 2,4-dinitrochlorobenzene, 10.6 grams (0.10 moles) of sodium carbonate, 80 milliliters of N-methyl Base-2-pyrrolidone, 200 milliliters of benzene and 30 milliliters of dichlorobenzene were put into the reaction kettle, stirred, heated to reflux and separated from water for 16 hours, concentrated the reaction solution, recovered the solvent for recycling, cooled the reactant system, added water, The solid product was precipitated, filtered, soaked in 2% dilute hydrochloric acid aqueous solution, filtered, washed with hot water for 2 to 3 times, and dried to obtain 44.2 grams of 3,7-bis(2,4-dinitrophenoxy)-2-naphthoic acid Crystalline product with a purity of 99.5%. According to the amount of 3,7-bis(2,4-dinitrophenoxy)-2-naphthoic acid actually obtained and the theoretical yield (53.6 grams), 3,7- The yield of bis(2,4-dinitrophenoxy)-2-naphthoic acid was 82.4%.
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