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Medicament for preventing and controlling stomach diseases

A drug and stomach disease technology, applied in the direction of drug combination, pharmaceutical formula, active ingredients of heterocyclic compounds, etc., can solve problems such as blood phosphorus reduction

Inactive Publication Date: 2008-12-10
成都厚发科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after the long-term use of the above-mentioned aluminum preparations and / or bismuth preparations, the aluminum or bismuth and the phosphate radicals in the gastric juice will form less water-soluble aluminum phosphate or bismuth phosphate precipitates to protect the gastric mucosa, and also easily lead to low blood phosphorus reduction. Phosphate side effects

Method used

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  • Medicament for preventing and controlling stomach diseases
  • Medicament for preventing and controlling stomach diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Dissolve lanthanum phosphate in 0.2mol / L hydrochloric acid, add activated carbon and boil for 30 minutes, let cool to room temperature, filter, add sodium hydroxide solution to adjust pH to neutral under stirring, let stand, filter, wash with deionized water, and dry To obtain lanthanum phosphate micropowder (particle size ≤ 100 μm), heavy metal ≤ 0.0005%, arsenic salt ≤ 0.0001%, take 100 g of lanthanum phosphate and add 200 g of medicinal starch, mix evenly, dry press granules, pack 1000 capsules, which is the capsule dosage form drug.

Embodiment 2

[0024] Get the lanthanum phosphate 100g, lactose 150g, hydroxymethylcellulose sodium 4g, and magnesium stearate 2g of the above example, mix uniformly, granulate with 50% ethanol, and press into 1000 tablets, which is the described tablet medicine.

Embodiment 3

[0026] 1-20 (wt)% lanthanum chloride solution and 1-20 (wt)% phosphoric acid are respectively continuously introduced into the reaction vessel at a flow rate of 1-100L / min, fully stirred, separated after standing and aging, and heated at 25°C-100 Wash the precipitated product with deionized water at ℃ to pH 5-7, and dry it to obtain submicron and nano-spherical lanthanum phosphate with a particle size of 10nm-5μm. Get this lanthanum phosphate 100g, omeprazole 10g, powdered sugar 345g, dextrin 145g, mix homogeneously, granulate with ethanol, subpackage, be described granule medicine.

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Abstract

The present invention relates to a medicine used for curing and preventing gastrosis, which comprises lanthanum orthophosphate and auxiliary ingredient acceptable in medicine jointly, or serves as compound type medicine consisting of lanthanum orthophosphate taken as a first medicine ingredient, antacid and / or antimicrobial type ingredient taken as a second medicine ingredient and auxiliary ingredient acceptable in medicine. The lanthanum orthophosphate is simple in preparation process, low in price of raw material and manufacturing cost, low in toxicity, satisfactory in protective effect of stomach mucous membrane with good medicine economics characteristic. The lanthanum orthophosphate can be developed as the new-generation anti-ulcerative medicine.

Description

technical field [0001] The invention relates to a medicine which can be used for preventing and treating stomach diseases, especially the medicine for preventing and treating stomach diseases including gastric ulcer and gastritis. Background technique [0002] Stomach diseases such as gastric ulcer and gastritis are relatively stubborn and frequently occurring diseases, which will cause great pain to the lives of patients. Gastric mucosal protective agents are a large class of drugs for the treatment of stomach diseases such as gastric ulcer and gastritis at present. Representative drugs mainly include aluminum preparations including aluminum hydroxide, etc., and bismuth preparations including bismuth citrate and the like. A large number of clinical data show that the use of gastric mucosal protective agents to treat gastric ulcer and gastritis can improve the healing quality and significantly reduce the recurrence rate. However, after the long-term use of the above-mention...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/24A61K31/4439A61K31/34A61P1/04
Inventor 周家明张生富陈岗
Owner 成都厚发科技开发有限公司
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