Vitamin orally disintegrating tablet and preparation method thereof
A technology of orally disintegrating tablets and vitamins, which is applied in the direction of pharmaceutical formulas, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., can solve the problems of fragility, low content of disintegrants, and immature development , to achieve the effect of solving the taste problem, facilitating industrialization, and simplifying the preparation process
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Embodiment 1
[0024] Component Content / tablet
[0025] Vitamin A 1500I.U. (equivalent to 3mg vitamin A microcapsules)
[0026] Vitamin D 3 or D 2 500I.U. (equivalent to 5mg vitamin D microcapsules)
[0027] Microcrystalline Cellulose 50mg
[0028] Mannitol 80mg
[0029] L-HPC 10mg
[0030] HPMC 1.4mg
[0031] Fragrance 0.8mg
[0032] Micronized silica gel 1mg
[0033] A-k sugar 0.8mg
[0035] Tablet weight 153mg
[0036] Preparation method: Weigh microcrystalline cellulose, L-HPC and mannitol according to the prescription, mix them evenly, add 5% HPMC binder prepared with 95% ethanol solution, granulate at 26 mesh, dry at 50°C, 26 mesh Whole grains, then add the prescribed amount of vitamin A microcapsules, vitamin D microcapsules, essence, micropowder silica gel, A-k sugar, magnesium stearate, mix evenly, and press into tablets. (Directly add flavoring agent, wet granulation and tabletting process)
Embodiment 2
[0038] Component Content / tablet
[0039] Vitamin A 2000I.U. (equivalent to 4mg vitamin A microcapsules)
[0040] Vitamin D 3 or D 2 700I.U. (equivalent to 7mg vitamin D microcapsules)
[0041] Microcrystalline Cellulose 50mg
[0042] Mannitol 80mg
[0043] L-HPC 10mg
[0044] Fragrance 0.8mg
[0045] Micronized silica gel 1mg
[0046] A-k sugar 1mg
[0048] Tablet weight 154.8mg
[0049] Preparation method: Weigh microcrystalline cellulose for direct compression, L-HPC, mannitol for direct compression, vitamin A microcapsules, vitamin D microcapsules, essence, micronized silica gel, A-k sugar, magnesium stearate according to the prescription, Mix evenly and directly compress into tablets. (directly add flavoring agent, direct compression process)
Embodiment 3
[0051] Component Content / tablet
[0052] Vitamin A 25000I.U. (equivalent to 50mg vitamin A microcapsules)
[0053] Microcrystalline Cellulose 75mg
[0054] Mannitol 80mg
[0055] L-HPC 15mg
[0056] PVP k30 1.8mg
[0057] PVPP 5mg
[0058] Fragrance 1.0mg
[0059] Micronized silica gel 1mg
[0060] Aspartame 0.5mg
[0062] Tablet weight 230.3mg
[0063] Preparation method: Weigh microcrystalline cellulose, L-HPC and mannitol according to the prescription, mix evenly, add 5% pvpk30 binder prepared with 75% ethanol solution, granulate with 26 mesh, dry at 50°C, 26 Whole grains, then add the prescribed amount of vitamin A microcapsules, crospovidone, essence, micronized silica gel, aspartame, magnesium stearate, mix evenly, and press into tablets. (Directly add flavoring agent, wet granulation and tabletting process)
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