Vitamin orally disintegrating tablet and preparation method thereof

A technology of orally disintegrating tablets and vitamins, which is applied in the direction of pharmaceutical formulas, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., can solve the problems of fragility, low content of disintegrants, and immature development , to achieve the effect of solving the taste problem, facilitating industrialization, and simplifying the preparation process

Active Publication Date: 2009-01-28
HANGZHOU MINSHENG HEALTHCARE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the sale of currently commercially available vitamin AD drops (soft capsule type) is very good, and almost every infant needs to take it, but this product also has certain deficiencies
First, compared with orally disintegrating tablets, taking it is not convenient enough, because taking it still requires tools to cut or puncture
Second, the dosage is not accurate enough, because it is necessary to cut or puncture the tip of the soft capsule when using it, squeeze it and drop it into the mouth of infants or young children or milk, it is impossible to squeeze out all the contents, and sometimes even spray and leak
Third, the taste is not good enough. Perhaps when infants are young, their sense of taste is not yet fully developed, and they are willing to take vitamin AD drops; as they gr

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Component Content / tablet

[0025] Vitamin A 1500I.U. (equivalent to 3mg vitamin A microcapsules)

[0026] Vitamin D 3 or D 2 500I.U. (equivalent to 5mg vitamin D microcapsules)

[0027] Microcrystalline Cellulose 50mg

[0028] Mannitol 80mg

[0029] L-HPC 10mg

[0030] HPMC 1.4mg

[0031] Fragrance 0.8mg

[0032] Micronized silica gel 1mg

[0033] A-k sugar 0.8mg

[0034] Magnesium Stearate 1mg

[0035] Tablet weight 153mg

[0036] Preparation method: Weigh microcrystalline cellulose, L-HPC and mannitol according to the prescription, mix them evenly, add 5% HPMC binder prepared with 95% ethanol solution, granulate at 26 mesh, dry at 50°C, 26 mesh Whole grains, then add the prescribed amount of vitamin A microcapsules, vitamin D microcapsules, essence, micropowder silica gel, A-k sugar, magnesium stearate, mix evenly, and press into tablets. (Directly add flavoring agent, wet granulation and tabletting process)

Embodiment 2

[0038] Component Content / tablet

[0039] Vitamin A 2000I.U. (equivalent to 4mg vitamin A microcapsules)

[0040] Vitamin D 3 or D 2 700I.U. (equivalent to 7mg vitamin D microcapsules)

[0041] Microcrystalline Cellulose 50mg

[0042] Mannitol 80mg

[0043] L-HPC 10mg

[0044] Fragrance 0.8mg

[0045] Micronized silica gel 1mg

[0046] A-k sugar 1mg

[0047] Magnesium Stearate 1mg

[0048] Tablet weight 154.8mg

[0049] Preparation method: Weigh microcrystalline cellulose for direct compression, L-HPC, mannitol for direct compression, vitamin A microcapsules, vitamin D microcapsules, essence, micronized silica gel, A-k sugar, magnesium stearate according to the prescription, Mix evenly and directly compress into tablets. (directly add flavoring agent, direct compression process)

Embodiment 3

[0051] Component Content / tablet

[0052] Vitamin A 25000I.U. (equivalent to 50mg vitamin A microcapsules)

[0053] Microcrystalline Cellulose 75mg

[0054] Mannitol 80mg

[0055] L-HPC 15mg

[0056] PVP k30 1.8mg

[0057] PVPP 5mg

[0058] Fragrance 1.0mg

[0059] Micronized silica gel 1mg

[0060] Aspartame 0.5mg

[0061] Magnesium Stearate 1mg

[0062] Tablet weight 230.3mg

[0063] Preparation method: Weigh microcrystalline cellulose, L-HPC and mannitol according to the prescription, mix evenly, add 5% pvpk30 binder prepared with 75% ethanol solution, granulate with 26 mesh, dry at 50°C, 26 Whole grains, then add the prescribed amount of vitamin A microcapsules, crospovidone, essence, micronized silica gel, aspartame, magnesium stearate, mix evenly, and press into tablets. (Directly add flavoring agent, wet granulation and tabletting process)

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Abstract

The invention provides a vitamin orally disintegrating tablet and a preparation method thereof; the medical prescription components comprise the combination of multiplex vitamins or single vitamin, a loading agent, a disintegrant, a sacarina and a lubricant, etc. The invention aims at providing the vitamin orally disintegrating tablet with simple technique and convenient taking, and is characterized in that the technical requirements are achieved by using disintegration technology and sacarina technology to make synergic action. The vitamin orally disintegrating tablet provided by the invention are rapidly disintegrated in the oral cavity into fine particles, so as to be beneficial to the dissolving and absorption of the vitamin, thus achieving the goal of effectively supplementing the vitamin needed by the human body in time. The preparation of the invention can be taken conveniently and is especially suitable for the people such as old people, children and the patients with some diseases who have swallowing difficulty and need to supplement vitamin, or in the special environment such as having no drinkable water in a journey and out of home.

Description

technical field [0001] The invention relates to a vitamin orally disintegrating tablet and a preparation method thereof. Background technique [0002] Vitamins are a kind of nutrients necessary to maintain human health. They are auxiliary components of the enzyme system in the human body, participate in a wide range of biochemical reactions in the human body, and regulate the metabolic functions of the human body. Although the amount required is very small, once the human body lacks vitamins, the metabolism will be lost. Balance, immunity decline, various diseases will take advantage of it. Conversely, clinically, when the human body is in a disease state, it usually lacks one or several vitamins, and vitamin supplementation has become a routine treatment for many. For example, colds, tonsillitis, and pharyngitis often require vitamin C and B vitamins, and oral ulcers often require vitamin B supplementation. 2 . [0003] Generally speaking, as long as the food structure i...

Claims

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Application Information

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IPC IPC(8): A61K31/714A61K9/20A61K47/34A61K47/36A61K47/38A61P3/02A61K31/015A61K31/07A61K31/197A61K31/355A61K31/375A61K31/4415A61K31/455A61K31/51A61K31/525A61K31/519A61K31/59
Inventor 李萌郭殿武丁仲杰吴春霞沈慈敏
Owner HANGZHOU MINSHENG HEALTHCARE CO LTD
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