External-use sertaconazole nitrate suppositorium

A technology for sertaconazole nitrate and conazole suppositories, which is applied in the direction of suppository delivery, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of high curative effect, high recurrence rate, adverse reactions, etc., and achieve the preparation process Simple, fungal infection suppression, good therapeutic effect

Inactive Publication Date: 2009-03-04
HAINAN HAISHEN TONGZHOU PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Miconazole nitrate suppository is mainly used for local treatment of double infection caused by vulvovaginal candidiasis and Gram-positive bacteria, but the recurrence rate is high after cure, and the drug resistance is strong after long-term and large-scale use, and the curative effect is poor
Xiaomi suppository is mainly used for the treatment of cervical erosion, trichomonas vaginitis, fungal vaginitis and other diseases, the curative effect is slow, the recurrence rate is high, and it is not easy to be accepted by patients
Metronidazole suppositories are mainly used for the treatment of trichomoniasis vaginalis, long-term use is likely ...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Grind sertaconazole nitrate and pass through a 80-120 mesh sieve for later use. Take 2000g of cocoa soybean butter, 35g of glycerin, and 15g of polysorbate 80 respectively, heat to 50°C, and mix the above three substances evenly after the cocoa soybean butter melts Get the mixed solution and keep it warm for later use; take 100g of sertaconazole nitrate and add it to the mixed solution, pass it through a colloid mill, fully stir and mix to obtain a mixed drug solution, inject the mixed drug solution into the plug shell, cool, seal, and pack to obtain 1000 capsules A suppository with a specification of 0.1 g.

Embodiment 2

[0021] Grind sertaconazole nitrate and pass through a 80-120 mesh sieve for later use. Take 1900g of semi-synthetic fatty acid lipid, 45g of glycerin, and 25g of polysorbate 80 respectively, heat to 60°C, and dissolve the above three substances after the semi-synthetic fatty acid lipid is melted. Mix evenly to obtain a mixed solution, keep it warm for later use; take 300g of sertaconazole nitrate and add it to the mixed solution, pass it through a colloid mill, stir and mix thoroughly to obtain a mixed drug solution, inject the mixed drug solution into the plug shell, cool, seal, and pack to obtain 1000 suppositories with a specification of 0.3g.

Embodiment 3

[0023] Grind sertaconazole nitrate and pass through a 80-120 mesh sieve for later use. Take 1800 g of polyethylene glycol 2000, 30 g of glycerin, and 10 g of polysorbate 80, respectively, and heat to 70 ° C. After the polyethylene glycol 2000 melts, the above three The two substances are mixed evenly to obtain a mixed solution, which is kept warm for later use; 500 g of sertaconazole nitrate is added to the mixed solution, passed through a colloid mill, fully stirred and mixed to obtain a mixed medicinal solution, and the mixed medicinal solution is injected into the plug shell, cooled, sealed, and packaged Promptly get 1000 suppositories whose specification is 0.5g.

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PUM

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Abstract

The invention provides an external nitric acid Sertaconazole suppository, which is a suppository of different specifications made by mixing the powder of ground nitric acid Sertaconazole and melt suppository base, glycerol and Polysorbate 80. The suppository has the beneficial effects that the preparation process of the suppository is simple, the eutherapeutic and low-toxic nitric acid Sertaconazole are used as the main medicaments, a greater cure effect can be achieved by using a small amount of medicament for local application, mycotic infection is inhibited, the cure effect is good, the use is convenient, etc.

Description

technical field [0001] The invention relates to a gynecological preparation, in particular to an external sertaconazole nitrate suppository for women's vaginal sterilization. Background technique [0002] With the development of society, the pollution of the environment is becoming more and more serious, and the pace of life is accelerating, which leads to a great decline in people's resistance. Women living in cities, especially middle-aged and elderly women, are prone to vaginal itching, vaginitis, including trichomonas vaginalis Vaginitis, mycotic vaginitis, candida vaginitis, cervicitis and other gynecological diseases. The pathogenic microorganisms that cause vaginal infections include fungi, bacteria, trichomonas, mycoplasma, etc., which seriously affect women's physical and mental health. [0003] Currently on the market for external vaginal suppositories used for gynecological diseases mainly include miconazole nitrate suppository, Xiaomi suppository, metronidazole s...

Claims

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Application Information

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IPC IPC(8): A61K9/02A61K31/4178A61P15/02
Inventor 李丙寅渠继鸿潘银霞黄小东
Owner HAINAN HAISHEN TONGZHOU PHARM CO LTD
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