Preparation method of gene coatings of medical device

A medical device and gene technology, applied in the field of preparation of gene coatings, can solve the problems of increasing matrix inflammation and restenosis, and achieve the effects of avoiding inflammation and restenosis, simple operation, and strong industrial practicability
CN101491468BActive Publication Date: 2011-04-20LEPU MEDICAL TECH (BEIJING) CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
LEPU MEDICAL TECH (BEIJING) CO LTD
Publication Date
2011-04-20

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Abstract

The invention relates to a method for preparing a gene-coated medical apparatus. The method utilizes the anode polarization principle, uses a medical apparatus body as an anode, and places the anode and the cathode of a power supply into solution of gene or oligonucleotide for anode polarization reaction so as to obtain the medical apparatus of which the surface carries a gene coating. The methodis simple and feasible, does not need to introduce matrix loaded with the gene, and avoids inflammation and side effects brought by the substrate; the apparatus body is evenly coated with the gene orthe oligonucleotide, the gene or the oligonucleotide coating has good stability, the activity is not influenced by a technical process, and the gene or the oligonucleotide is easily and slowly released into vascular cells so as to express in vascular wall cells; and the medical apparatus can prevent and treat inflammation reaction and restenosis in the medical apparatus more effectively.
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Description

technical field

[0001] The invention relates to a medical device, in particular to a method for preparing a gene coating on a medical device. Background technique

[0002] Atherosclerosis causes the stenosis of the blood vessel lumen, which leads to the obstacle of blood supply and oxygen supply to the muscle and causes muscle ischemia and necrosis in the corresponding part. In 1976, German scholar Andrea Gronzgo first proposed the idea of ​​installing stents in arteries. By the 1990s, coronary stents had been widely used as a medical device for clinical treatment.

[0003] Currently commonly used vascular stents can be divided into bare stents, drug-eluting stents, polymer-coated stents, metal-coated stents, radioactive stents and artificial blood vessel-covered stents according to the surface state. The restenosis rate is small, people have developed radioactive stents and drug-eluting stents, wherein the drugs are various therapeutic agents, etc., and now drug-eluting st...

Claims

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