Preparation method of carbon nano-tube reinforced silicon-containing hydroxylapatite bone-cement biological material

A technology of silicon hydroxyapatite and biomaterials, applied in medical science, prosthesis, etc., can solve the problems of difficult control of reaction conditions and complicated operation, and achieve the effect of good combination and uniform dispersion

Inactive Publication Date: 2009-07-29
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the mechanical properties of the composite materials prepared by the above methods have

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: 1): Preparation of silicon-containing hydroxyapatite powder

[0025] a. Analytical pure calcium nitrate [Ca(NO 3 ) 2 4H 2 O], diammonium hydrogen phosphate [(NH 4 ) 2 HPO 4 ] and urea [CO(NH 2 ) 2 ] are respectively configured into solutions of 0.03mol / l, 0.05mol / l and 0.6mol / l, and are marked as A, B, and C solutions respectively;

[0026] b. Mix the three solutions of A, B and C according to the volume ratio of 2:1:2 and record it as solution D;

[0027] c. Take 100ml of D solution and place it in a three-necked flask, add 0.15ml of chemically pure ethyl orthosilicate solution, and react in a microwave chemical reactor at 80°C for 4 hours;

[0028] d. After the reaction is over, take out the three-necked flask after natural cooling with the microwave chemical reaction instrument to obtain a white suspension;

[0029] e. Pour the white suspension into a beaker and let it stand at room temperature for 24h-96h. The suspension is divided into upper ...

Embodiment 2

[0042] Embodiment 2: 1): Preparation of silicon-containing hydroxyapatite powder

[0043] a. Analytical pure calcium nitrate [Ca(NO 3 ) 2 4H 2 O], diammonium hydrogen phosphate [(NH 4 ) 2 HPO 4 ] and urea [CO(NH 2 ) 2 ] are respectively configured into solutions of 0.031mol / l, 0.02mol / l and 0.44mol / l, which are respectively marked as A, B, and C solutions;

[0044] b. Mix the three solutions of A, B and C according to the volume ratio of 2:1:4 and record it as solution D;

[0045] c. Take 100ml of D solution and place it in a three-necked flask, add 0.08ml of chemically pure ethyl silicate solution, and then react in a microwave chemical reactor at 60°C for 7h;

[0046] d. After the reaction is over, take out the three-necked flask after natural cooling with the microwave chemical reaction instrument to obtain a white suspension;

[0047] e. Pour the white suspension into a beaker and let it stand at room temperature for 24h-96h. The suspension is divided into upper a...

Embodiment 3

[0060] Embodiment 3: 1): Preparation of silicon-containing hydroxyapatite powder

[0061] a. Analytical pure calcium nitrate [Ca(NO 3 ) 2 4H 2 O], diammonium hydrogen phosphate [(NH 4 ) 2 HPO 4 ] and urea [CO(NH 2 ) 2 ] are respectively configured into solutions of 0.04mol / l, 0.01mol / l and 0.8mol / l, and are respectively marked as A, B, and C solutions;

[0062] b. Mix the three solutions of A, B and C according to the volume ratio of 2:1:3 and record it as solution D;

[0063] c. Take 100ml of D solution and place it in a three-necked flask, add 3.00ml of chemically pure ethyl orthosilicate solution, and react in a microwave chemical reactor at 100°C for 1 hour;

[0064] d. After the reaction is over, take out the three-necked flask after natural cooling with the microwave chemical reaction instrument to obtain a white suspension;

[0065] e. Pour the white suspension into a beaker and let it stand at room temperature for 24h-96h. The suspension is divided into upper ...

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Abstract

The invention relates to a method for preparing a nanotube-reinforced silicon-substituted hydroxyapatite and bone cement biomaterial, which comprises the following steps of: mixing a solution of calcium nitrate, a solution of ammonium dibasic phosphate and a solution of urea to obtain D; adding a chemical pure tetraethyl orthosilicate solution into the solution D and placing the mixture in a microwave chemical reactor for reaction to obtain a white suspension; removing a supernatant of the suspension through filtration to obtain a sample E; drying, calcining and grinding the sample E to obtain silicon-substituted hydroxyapatite powder, adding a silane coupling agent and absolute ethanol into the silicon-substituted hydroxyapatite powder and subjecting to mixture to ultrasonic dispersion to obtain F; placing carbon fibers in deionized water, adding carboxymethylcellulose sodium, the sample F and potassium persulfate into the deionized water and subjecting the mixture to ultrasonic dispersion to obtain G; mixing acrylic acid and itaconic acid to obtain a mixed solution H1; adding sodium citrate into the mixed solution H1 to obtain a mixed solution H2; and placing a sample of K in a watch glass, adding the solution H2I into the watch glass, transferring the mixture into a mould for curing and obtaining the target product. In the composite prepared by the method, the carbon fibers distribute uniformly and are desirably combined with a substrate interface, so the composite is a biomedical composite with wide application prospect.

Description

technical field [0001] The invention relates to a preparation method of reinforced bone cement biological material, in particular to a preparation method of carbon fiber reinforced silicon-containing hydroxyapatite bone cement biological material. Background technique [0002] Hydroxyapatite is the main inorganic component of vertebrate bones and teeth, and has excellent biocompatibility and bioactivity. Human bone cells can form chemical bonds directly on hydroxyapatite, and the bonding strength is high and the stability is good, so it is widely used as a hard tissue replacement material. However, hydroxyapatite itself has low strength and high brittleness, so it can only be used in non-load-bearing materials such as alveolar ridge enhancement, ear ossicle replacement, and maxillofacial bone repair, but it is difficult to apply to load-bearing bones, so p-hydroxyapatite is needed Stone strengthens and toughens. At present, the domestic and foreign methods of strengthening...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/12A61L27/08
Inventor 黄剑锋李娟莹曹丽云王文静殷立雄吴建鹏
Owner SHAANXI UNIV OF SCI & TECH
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