Terbinafine hydrochloride vaginal effervescent tablet and preparation method thereof
A technology of terbinafine hydrochloride and effervescent tablets, which is applied in the field of medicine, can solve the problems of complex production process and high cost of excipients, and achieve the effects of simple preparation process, easy operation and improved stability
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Embodiment 1
[0014] Embodiment 1: Terbinafine hydrochloride vaginal effervescent tablet, the prescription component is:
[0015] Terbinafine Hydrochloride 150g
[0016] Lactose 70g
[0017] Citric acid 100g
[0018] Sodium bicarbonate 100g
[0019] Low-substituted hydroxypropyl cellulose 30g
[0020] Sodium Lauryl Sulfate 10g
[0022] Anhydrous ethanol amount
[0023] Makes 1000 pieces
[0024] Preparation process: a) Treatment of raw and auxiliary materials: drying and dehydrating the required raw and auxiliary materials respectively, passing through 100 sieves, and weighing according to the prescription amount for later use. b) Preparation of soft materials: Take terbinafine hydrochloride, lactose, citric acid, sodium bicarbonate, low-substituted hydroxypropyl cellulose and sodium lauryl sulfate, mix them uniformly by equal addition method, and use an appropriate amount of anhydrous Ethanol for soft materials. c) Granulation: the prepared soft mate...
Embodiment 2
[0026] Embodiment 2: Terbinafine hydrochloride vaginal effervescent tablet, the prescription component is:
[0027] Terbinafine Hydrochloride 150g
[0028] Microcrystalline Cellulose 100g
[0029] Tartaric acid 140g
[0031] Sodium carboxymethyl starch 15g
[0032] Sodium Lauryl Sulfate 15g
[0034] 5% polyvinylpyrrolidone ethanol solution appropriate amount
[0035] Makes 1000 pieces
[0036] Preparation process: a) Treatment of raw and auxiliary materials: drying and dehydrating the required raw and auxiliary materials respectively, passing through 100 sieves, and weighing according to the prescription amount for later use. b) Preparation of soft materials: take terbinafine hydrochloride, microcrystalline cellulose, tartaric acid, sodium carbonate, sodium carboxymethyl starch and sodium lauryl sulfate, mix them uniformly with equal addition method, and use an appropriate amount of 5% polystyrene Vinylpyrr...
Embodiment 3
[0038] Embodiment 3: Terbinafine hydrochloride vaginal effervescent tablet, the prescription component is:
[0039] Terbinafine Hydrochloride 150g
[0040] Starch 100g
[0041] Citric acid 90g
[0042] Sodium bicarbonate 90g
[0043] Cross-linked polyvinylpyrrolidone 10g
[0044] Sodium Lauryl Sulfate 10g
[0046] Anhydrous ethanol amount
[0047] Makes 1000 pieces
[0048] Preparation process: a) Treatment of raw and auxiliary materials: drying and dehydrating the required raw and auxiliary materials respectively, passing through 100 sieves, and weighing according to the prescription amount for later use. b) Preparation of soft material: take terbinafine hydrochloride, starch, citric acid, sodium bicarbonate, cross-linked polyvinylpyrrolidone and sodium lauryl sulfate, mix them uniformly by equal addition method, and use appropriate amount of absolute ethanol Solution to prepare soft materials. c) Granulation: the prepared soft material is gra...
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