Method for synthesizing hydrogel

Abstract

The invention discloses a method for synthesizing hydrogel, one out of N, N-(dimethylamino) ethyl methacrylate or methylacrylic acid polyethylene glycol single methyl ether ester is taken as a monomer, the monomer, an initiator, a cross-linking agent, a catalyst, a complexing agent and a reductant are added according to the molar ratio that monomer: initiator: cross-linking agent: catalyst: complexing agent and reductant is equal to 100-1000: 1: 1-50: 0.05-3: 0.15-9: 1-10, so as to carry out the AGET ATRP reaction and synthesize the hydrogel; wherein the initiator is selected from one out of polyethylene glycol bis (alpha-bromoisobutyrate) ester or 2,6-dibromo dimethyl heptanedioate; the cross-linking agent is one out of ethylene glycol dimethacrylate or poly(ethylene glycol) dimethacrylate; and the catalyst is selected from one out of hexahydrated high ferric chloride or ferric bromide. The method can control the crosslinking degree by regulating the using amount of the cross-linking agent, so that the method can control the mesh size of the hydrogel, control the liquid absorption performance of the hydrogel and obtain the hydrogel with good biocompatibility.

Description

technical field [0001] The invention relates to a method for preparing a gel, in particular to a method for synthesizing a hydrogel. Background technique [0002] The colloidal particles or polymers in the sol or solution are connected to each other under certain conditions to form a space network structure, which is filled with liquid as a dispersion medium. Such a special dispersion system is called gel. Due to the affinity between the liquid and the polymer network, the liquid is enclosed by the polymer network and loses its fluidity, so the gel can display a certain shape like a solid. During the swelling process of the gel, on the one hand, the solvent tries to penetrate into the polymer to expand its volume, and on the other hand, due to the volume expansion of the cross-linked polymer, the molecular network is subjected to stress and shrinks. When these two opposite tendencies compete with each other , reaching the swelling equilibrium. The swelling behavior of poly...

AI Technical Summary

Problems solved by technology

The main disadvantages of these methods are: due to the high polymerization rate of conventional free radical polymerization and the thermal effect, chain transfer, chain termination reaction and self-acceleration phenomenon in the reaction process, the synthesized gel cannot control the cross-linking density and cross-linking density of the network. The molecular mass of the chain segments between the linking points and the distribution of cross-linking points are uneven and difficult to control. The structure of the synthesized polymer gel is in an amorphous state, without regularity, slow response to external environmental stimuli, and no synergy. Therefore, the synthesis The properties of the obtained gel are not ideal, which limits its application in material synthesis

[0007] However, the above method is used to synthesize linear polymers and does not involve the field of hydrogel synthesis; in addition, the catalysts involved in the above methods are basically limited to copper salt catalytic systems, and copper salt catalytic systems are due to their inherent biological toxicity. When it is applied to the synthesis of smart hydrogel materials with good biocompatibility, there is a problem of bringing greater toxicity to the materials.

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