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High fluorescence property nanometer composite microsphere and the production method thereof

A fluorescent performance, nano-microsphere technology, applied in chemical instruments and methods, luminescent materials, etc., can solve the problems of low fluorescence intensity, low luminous efficiency of products, environmental pollution, etc., and achieve high fluorescence intensity, good application prospects, and excellent fluorescence performance effect

Inactive Publication Date: 2009-10-28
TONGJI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the preparation system of its quantum dots is carried out in chloroform, which seriously pollutes the environment, and the prepared fluorescent quantum dots need to be changed from oil-soluble to water-soluble, and the fluorescence intensity will drop significantly, resulting in a very low luminous efficiency of the final product, which restricts Application of this fluorescent microsphere in vivo
For example, the patent (Application No. 200610031486.0) proposes a direct preparation method of silicon-shell CdTe quantum dots. In this method, a layer of silicon shell is directly formed to wrap around the prepared quantum dots during the preparation process, that is, a single quantum dot is formed. Fluorescent microsphere structure filled with silica, the fluorescence intensity is low due to the small content of quantum dots in the microsphere, and the fluorescence yield is not adjustable

Method used

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  • High fluorescence property nanometer composite microsphere and the production method thereof
  • High fluorescence property nanometer composite microsphere and the production method thereof
  • High fluorescence property nanometer composite microsphere and the production method thereof

Examples

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Effect test

Embodiment 1

[0024] Embodiment 1: add 0.25g cadmium chloride powder in 500ml of deionized water, magnetically stir to obtain a colorless and clear cadmium chloride solution, then add 85ul of mercaptoacetic acid for processing, and form a white precipitate in the solution. Under the conditions, adjust the pH value to 8-12 with concentrated ammonia water, and continue stirring at a rotating speed of 500rpm until the solution becomes colorless and transparent to obtain a cadmium chloride solution with well-dispersed mercapto groups, and obtain liquid A; take 0.02g of selenium powder and 0.2 Mix 2g of sodium borohydride, add 2ml of deionized water, react under the protection of argon until the black selenium powder disappears completely, and add this liquid to liquid A, fully react at a speed of 500rpm to obtain a cadmium selenide precursor Put this precursor in an autoclave and react under the condition of 220°C for 2 hours to produce a water-soluble cadmium selenide quantum dot solution with ...

Embodiment 2

[0027] Embodiment 2: add 0.25g cadmium chloride powder in 500ml deionized water, magnetically stir to obtain a colorless and clear cadmium chloride solution, then add 85ul of mercaptoacetic acid for processing, and form a white precipitate in the solution. Under the conditions, adjust the pH value to 8-12 with concentrated ammonia water, and continue to stir at a speed of 500 rpm until the solution becomes colorless and transparent to obtain a cadmium chloride solution with well-dispersed mercapto groups, and obtain liquid A; take 0.032 g of tellurium powder and 0.2 Mix 2g of sodium borohydride, add 2ml of deionized water, and react under the protection of argon until the black tellurium powder disappears completely, and add this liquid into liquid A, and fully react at a speed of 500rpm to obtain a cadmium telluride precursor body; put this precursor in an autoclave for hydrothermal reaction at 220°C for 2 hours to obtain a water-soluble cadmium telluride quantum dot solution ...

Embodiment 3

[0030] Embodiment 3: add 0.25g cadmium chloride powder in 500ml deionized water, magnetically stir to obtain a colorless and clear cadmium chloride solution, then add 85ul of mercaptoacetic acid for processing, and form a white precipitate in the solution. Under the conditions, adjust the pH value to 8-12 with concentrated ammonia water, and continue stirring at a rotating speed of 500rpm until the solution becomes colorless and transparent to obtain a cadmium chloride solution with well-dispersed mercapto groups, and obtain liquid A; take 0.02g of selenium powder and 0.1 Mix 2g of sodium borohydride, add 2ml of deionized water, react under the protection of argon until the black selenium powder disappears completely, and add this liquid to liquid A, fully react at a speed of 500rpm to obtain a cadmium selenide precursor Put this precursor in an autoclave and react under the condition of 220°C for 2 hours to produce a water-soluble cadmium selenide quantum dot solution with a f...

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Abstract

The invention belongs to the technical field of inorganic nanometer material, in particular relates to a high fluorescence property nanometer composite microsphere and the production method thereof. The high fluorescence property nanometer composite microsphere mainly comprises VI main group elements, IV main group elements and IIB transition group elements; the production method is a sol-gel method, and a plurality of fluorescence quantum dots which are surface-finished are inlaid in a silicon dioxide dielectric material in the range of 20-70 DEG C to form the high fluorescence property nanometer composite microsphere; and the fluorescence property and the particle size of the high fluorescence property nanometer composite microsphere can be adjusted through controlling the consumed amount of fluorescence quantum dots, alkoxysilane, alcohol and ammonia in the preparation process. The invention has easily-obtained raw material, low cost, simple operation and easy control; the obtained high fluorescence property nanometer composite microsphere has the advantages of good size controllability, adjustable fluorescence yield and the like, the particle size of the microsphere is 500nm-1000nm, and the quantum yield can change in the range of 15-25 percent; and due to good fluorescence property and good biocompatibility, the invention has wide application prospect in biological markers, medicine tracing, in vivo imaging and the like of the biological, medical and medicine fields.

Description

technical field [0001] The invention belongs to the technical field of inorganic nanometer materials, and in particular relates to a nanocomposite microsphere with high fluorescent performance and a preparation method thereof. Background technique [0002] Fluorescent materials generally refer to materials that emit photons as electrons transition between different energy bands. Such materials can be used as markers of cells and living organs in the field of bioengineering. For example, the patent (publication number CN101235187) discloses a magnetic fluorescent nanocomposite material, its preparation method and application. This material coats fluorescent polymers on the surface of iron oxide particles to obtain a composite material that can migrate under a magnetic field and can be used for environmental detection and cell labeling. However, the fluorescence yield of the fluorescent polymer used is not high, the photostability and photocorrosion resistance are poor, and ...

Claims

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Application Information

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IPC IPC(8): C09K11/88C09K11/59
Inventor 吴立功王德平姚爱华谢万兴黄文旵
Owner TONGJI UNIV
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