Method for preparing high-strength rib grads multi-aperture bracket

A gradient porous, high-strength technology, applied in the field of polymer materials and biomedical engineering, can solve the problems of increasing the suffering of patients, achieve the effects of improving biocompatibility, increasing mechanical strength, and simplifying the preparation process

Inactive Publication Date: 2009-11-11
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This undoubtedly increases the suffering of patients

Method used

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  • Method for preparing high-strength rib grads multi-aperture bracket
  • Method for preparing high-strength rib grads multi-aperture bracket
  • Method for preparing high-strength rib grads multi-aperture bracket

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] a. Use a standard sieve to sieve 7.2g of 125-224μm, 21.6g of 224-300μm, and 7.2g of 300-340μm sodium chloride respectively.

[0042] b. Weigh 0.8g, 2.4g, 0.8g of polymers with a mass ratio of polylactic acid and polycaprolactone of 7:3, respectively, and place them in three beakers, add 10ml, 30ml, and 10ml of chloroform, and stir magnetically Dissolving, the polylactic acid and polycaprolactone are dissolved to form a polymer blend solution.

[0043]c. Weigh 0.032g, 0.096g, and 0.032g of nano-hydroxyapatite respectively, add them to the polymer solution obtained in the previous step, stir magnetically for half an hour, and then vibrate ultrasonically for half an hour, so that the hydroxyapatite is evenly dispersed in the in the polymer solution.

[0044] d. Add 7.2g of 125-224μm, 21.6g of 224-300μm, and 7.2g of 300-340μm sodium chloride obtained in step a to the blend obtained in step c, and stir with a glass rod to disperse the salt evenly A pasty mixture with certa...

Embodiment 2

[0051] a. Sieve 18g of 125-224μm, 54g of 224-300μm, and 18g of 300-340μm potassium chloride with a standard sieve respectively.

[0052] b. Weigh 2g, 6g, and 2g of polylactic acid and place them in three beakers respectively, add 20ml, 60ml, and 20ml of dichloromethane respectively, stir and dissolve with magnetic force, and dissolve the polylactic acid to form a polymer solution.

[0053] c. Weigh 0.16g, 0.48g, and 0.16g of nano-hydroxyapatite respectively, add them to the polylactic acid solution obtained in the previous step, stir magnetically for half an hour, and then oscillate ultrasonically for 1 hour, so that the hydroxyapatite is evenly dispersed in the in polylactic acid solution.

[0054] d. Add 18g of 125-224μm, 54g of 224-300μm, and 18g of 300-340μm potassium chloride obtained in step a to the blend obtained in step c, and stir with a glass rod to disperse the salt evenly in the solution A pasty mixture with certain fluidity containing porogens with different par...

Embodiment 3

[0061] a. Use a standard sieve to sieve 7.2g of 125-224μm, 21.6g of 224-300μm, and 7.2g of 300-340μm sodium chloride respectively.

[0062] b. Weigh 0.8g, 2.4g, 0.8g of polymerized monomers with a molar ratio of LA:Cl of 7:3 copolymer PLCL respectively in three beakers, add 10ml, 30ml, 10ml of chloroform, magnetically Stir to dissolve, so that the copolymer PLCL dissolves to form a polymer solution.

[0063] c. Weigh 0.032g, 0.096g, and 0.032g of calcium silicate, respectively, and add them to the polymer solution obtained in the previous step, stir magnetically for half an hour, then ultrasonically shake for half an hour, so that the calcium silicate is evenly dispersed in the polymer solution middle.

[0064] d. Add 7.2g of 125-224μm, 21.6g of 224-300μm, and 7.2g of 300-340μm sodium chloride obtained in step a to the blend obtained in step c, and stir with a glass rod to disperse the salt evenly A pasty mixture with certain fluidity containing porogens with different parti...

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Abstract

The invention belongs to the technical fields of polymer materials and biomedical engineering, and particularly relates to a method for preparing a high-strength rib grads multi-aperture bracket. The invention can regulate and control apertures and aperture distribution in the bracket by adjusting apertures of porogen, and simulate characteristics of compact and spongy substance apertures of natural bones to prepare the multi-aperture bracket with grads apertures. The invention adopts hydroxylapatite or calcium titanium silicate not only to regulate the relative constant of pH value but also to enhance the biocompatibility and mechanical strength of the material of the bracket; simultaneously, the invention adopts sticking manner to utilize a mechanical property strengthening layer betweentwo layers of grads multi-aperture bracket so as to meet the requirement on the mechanical property of rib bracket.

Description

technical field [0001] The invention belongs to the technical fields of polymer materials and biomedical engineering. Specifically relates to a preparation method of a high-strength rib gradient porous support. Background technique [0002] The concept of tissue engineering and tissue engineering scaffolds has broken the shackles of autologous bone transplantation and allogeneic bone transplantation on the treatment of bone defects, bone tumors, osteomyelitis and other diseases, and provided a wider choice for patients. Tissue engineering scaffolds are also commonly used in the treatment of rib diseases such as rib fractures, injuries, and rib loss. [0003] At present, the materials of rib tissue engineering scaffolds used clinically are mainly metal materials. Tissue engineering scaffolds made of metal are not biodegradable after surgical implantation, and a second surgery is required to remove them after the therapeutic purpose is achieved. This undoubtedly increases t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/56A61L27/58A61F2/28A61L27/18A61L27/12A61L27/02
Inventor 任天斌宋莹王安
Owner TONGJI UNIV
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