Preparation method of superparamagnetic cyclodextrin composite particles

A composite particle, superparamagnetic technology, applied in the direction of diamagnetic/paramagnetic materials, organic materials/organic magnetic materials, medical preparations with inactive ingredients, etc. and other problems, to achieve the effect of simple post-processing and high output

Active Publication Date: 2009-11-18
XIAN GOLDMAG NANOBIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method is relatively complicated, the steps are cumbersome, and the synthesis is difficult.
[0003] From the above review, it can be seen that the existing methods for synthesizing magnetic cyclodextrin composite particles have certain defects.

Method used

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  • Preparation method of superparamagnetic cyclodextrin composite particles
  • Preparation method of superparamagnetic cyclodextrin composite particles
  • Preparation method of superparamagnetic cyclodextrin composite particles

Examples

Experimental program
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Effect test

Embodiment 1

[0035] Add 3 milliliters of distilled water to a 50 milliliter round-bottomed flask containing 0.2104 g of magnetic ferric ferric oxide solid powder obtained by the co-precipitation method to obtain a magnetic nanoparticle mixed system containing a small amount of water. After adding 0.7009 grams of α-cyclodextrin and 1.6 milliliters of ammonia solution to the mixed system, 100 watts of ultrasonic dispersion was used for 5 minutes to obtain a uniform dispersion system with pH = 12. The temperature of the reaction system was increased to 40 ° C, and Hold at temperature for 3 hours. After the reaction is finished, it is repeatedly washed by means of magnetic separation, centrifugation or dialysis until the solution becomes neutral, and superparamagnetic α-cyclodextrin composite particles are obtained.

Embodiment 2

[0037] Pipette 300 mg of magnetic ferric oxide aqueous solution, discard the supernatant after magnetic separation, add 2.7 ml of water, 581.2 mg of hydroxypropyl-β-cyclodextrin and 1.2 ml of ammonia solution, and disperse with 100-watt ultrasonic for 20 minutes Afterwards, a uniform dispersion system with pH=13 was obtained, and the temperature of the reaction system was raised to 50° C. and kept at this temperature for 6 hours. After the reaction is finished, it is repeatedly washed by magnetic separation, centrifugation or dialysis until the solution becomes neutral, and then superparamagnetic hydroxypropyl-β-cyclodextrin composite particles are obtained.

Embodiment 3

[0039] Pipette co-precipitation method to obtain 5.53 ml of magnetic ferric ferric oxide fluid (solid content 36.2 mg / ml) in a 50 ml round bottom flask, place on a magnet to separate until the upper layer is clear, and discard the upper aqueous solution. Add 1.9393 mg of γ-cyclodextrin and 2.0 ml of water. Using 1M NaOH, adjust the pH of the system to 10, disperse with 100 watts of ultrasound for 5 minutes, raise the temperature of the reaction system to 70° C., and keep it at this temperature for 5 hours. After the reaction is finished, the superparamagnetic gamma-cyclodextrin composite particles are obtained by known methods such as magnetic separation, centrifugation or dialysis.

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Abstract

The invention relates to a preparation method of superparamagnetic cyclodextrin composite particles. The preparation method comprises the following steps: firstly preparing a magnetic nanometer particle mixed system, and then, adding cyclodextrin powder; adding the cyclodextrin powder to the obtained magnetic nanometer particle mixed system containing a small amount of water and adjusting the pH value of the magnetic nanometer particle mixed system to be larger than 10 by an aqueous alkali; dispersing the cyclodextrin powder under ultrasound for 5-30 minutes so as to dissolve cyclodextrin; and obtaining the superparamagnetic cyclodextrin composite particles by compounding, increasing the temperature of the reaction system to 40-80 DEG C, fully stirring the reaction system and reacting for 3-20 hours before ending, and magnetically separating and centrifugating or dialyzing the system to be neutral so as to obtain the magnetic cyclodextrin composite particles. The invention aims to utilize active groups of the cyclodextrin and the magnetic nanometer particles and does not need adding a coupling reagent so as to be directly compounded into the magnetic composite particles which have high biological compatibility and saturation magnetization intensity and can slowly release a plurality of medicaments.

Description

technical field [0001] The invention belongs to the field of material synthesis, and particularly relates to a preparation method for synthesizing superparamagnetic cyclodextrin composite microparticles without coupling reagents by using superparamagnetic nanoparticles and active groups of cyclodextrin itself. Background technique [0002] With the development of magnetic nanomaterial technology, the application of magnetic composite particles in biology is also increasing. Compared with other linear biocompatible polymers, such as dextran and starch, cyclodextrin has significantly different properties. It is composed of 6, 7, 8 or more D-glucopyranose units connected by α-1, 4 glycosidic bonds, and has a cone-shaped cylindrical cavity structure with a diameter of 0.5-0.8 nanometers. All 6- The primary hydroxyl group is at the small mouth end of the cylinder cavity, that is, the first surface, and all the 2,3-position secondary hydroxyl groups are at the large mouth end of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/02A61K47/40
CPCA61K9/0009A61K9/5094H01F1/42A61K47/48969B82Y5/00H01F1/0018A61K47/48861A61K47/6923A61K47/6951
Inventor 彭明丽崔亚丽陈超刘艳红张华张彩权
Owner XIAN GOLDMAG NANOBIOTECH
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