Compound slow release preparation of pseudoephedrine, chlorphenamine and dextromethorphan

A slow-release preparation, pseudoephedrine technology, which is applied in the directions of non-active ingredients medical preparations, active ingredients-containing medical preparations, pharmaceutical formulas, etc. Side effects and other issues, to achieve the effect of less medication frequency, high safety, and reduced medication frequency

Inactive Publication Date: 2009-12-09
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the short half-life of dextromethorphan, the general dose is 15-30 mg, which needs to be admini...

Method used

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  • Compound slow release preparation of pseudoephedrine, chlorphenamine and dextromethorphan
  • Compound slow release preparation of pseudoephedrine, chlorphenamine and dextromethorphan
  • Compound slow release preparation of pseudoephedrine, chlorphenamine and dextromethorphan

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] prescription:

[0021] Pseudoephedrine hydrochloride

90g

Chlorpheniramine Maleate

4g

Dextromethorphan Hydrobromide

30g

carnauba wax

45g

Acrylic

25g

microcrystalline cellulose

46g

10% Povidone K 30 aqueous solution

Appropriate amount

Magnesium stearate

Appropriate amount

[0022] Coating prescription:

[0023] Opadry

10g

pure water

Add to 1000ml

[0024] Made into 1000 grains (tablets)

[0025] Preparation method 1:

[0026] (1) Preparation of granules Carnauba wax, acrylic resin, and microcrystalline cellulose were respectively passed through an 80-mesh sieve and mixed uniformly. Then add pseudoephedrine hydrochloride, chlorpheniramine maleate, and dextromethorphan hydrobromide in turn, mix well, and add 10% povidone K 30 The aqueous solution is a soft material made of an adhesive, wet granules are prepared through a 20-me...

Embodiment 2

[0043] prescription:

[0044] Pseudoephedrine hydrochloride

60g

Dextromethorphan Hydrobromide

15g

Chlorpheniramine Maleate

2g

Cellulose acetate

20g

Hypromellose E5

55g

lactose

65g

10% Povidone K 30 aqueous solution

Appropriate amount

Talc powder

Appropriate amount

[0045] Coating prescription:

[0046] Chlorpheniramine maleate

2g

Opadry II

10g

pure water

Appropriate amount until completely dissolved

[0047] Made into 1000 grains (tablets)

[0048] Preparation method 1:

[0049] (1) Preparation of granules: Cellulose acetate, hydroxypropylmethylcellulose E5, and lactose were respectively passed through an 80-mesh sieve, fully mixed with equal increments, and then added pseudoephedrine hydrochloride, dextromethorphan hydrobromide, Chlorpheniramine maleate, mix it well with 10% Povidone K 30 The aqueous solution is a so...

Embodiment 3

[0068] prescription:

[0069] pseudoephedrine sulfate

40g

Chlorpheniramine maleate

1g

Dextromethorphan Hydrobromide

15g

sodium alginate

20g

gelatin

28g

pregelatinized starch

50g

10% Povidone K 25 aqueous solution

Appropriate amount

[0070] Coating prescription:

[0071] pseudoephedrine sulfate

5g

Chlorpheniramine maleate

1g

Cellulose diacetate

15g

ethanol

Appropriate amount until completely dissolved

[0072] Made into 1000 grains (tablets)

[0073] Preparation:

[0074] (1) Preparation of granules Sodium alginate, gelatin, and pregelatinized starch were respectively passed through a 100-mesh sieve, fully mixed in equal increments, and then added with prescribed amounts of pseudoephedrine sulfate, chlorpheniramine maleate, and hydrobromic acid Dextromethorphan, mixed well with 10% Povidone K 25 The aqueous solution ...

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PUM

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Abstract

The invention relates to a slow release preparation taking pseudoephedrine or physiologically acceptable salt thereof, chlorphenamine or physiologically acceptable salt thereof and dextromethorphan or physiologically acceptable salt thereof as active ingredients. The slow release preparation is characterized in that a releasing system comprises a tablet core and/or pill core capable of enabling a medicament to slowly release and a coating, wherein one part and/or all of the active ingredients exist in the tablet core and/or pill core, and the rest of the active ingredients exist in the coating.

Description

technical field [0001] The invention relates to a slow-release preparation with pseudoephedrine or its physiologically acceptable salt, chlorpheniramine or its physiologically acceptable salt and dextromethorphan or its physiologically acceptable salt as active ingredients. Background technique [0002] The common cold, called "cold" by the motherland's medical science, is a kind of respiratory common disease caused by multiple viruses, wherein 30%-50% is caused by a certain serotype of rhinovirus. Though common cold is mainly in early winter, in any season, as can taking place in spring, summer, the Causative virus of the flu of Various Seasonals is not just the same yet. The distribution of cold cases is sporadic, does not cause epidemics, and is often easily combined with bacterial infections. The onset of the common cold is rapid, and early symptoms include dry itching or burning sensation in the throat, sneezing, nasal congestion, runny nose, accompanied by sore throat...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/485A61K31/4402A61K31/137A61K47/30A61P11/00A61P31/12
Inventor 林鹏李育巧郑顺利
Owner COSCI MED TECH CO LTD
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