Preparation method of chitosan-silicon dioxide compound hollow microballoon and application thereof

A technology of hollow microspheres and silicon dioxide, applied in the field of molecular sieves and carriers, can solve the problems of complex preparation process, etc., and achieve the effect of high mechanical strength, good stability, and not easy to deform

Inactive Publication Date: 2009-12-16
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation process of the above methods is relatively complicated, and sometimes it is unavoidable to use organic solvents that are harmful to the human body.

Method used

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  • Preparation method of chitosan-silicon dioxide compound hollow microballoon and application thereof
  • Preparation method of chitosan-silicon dioxide compound hollow microballoon and application thereof
  • Preparation method of chitosan-silicon dioxide compound hollow microballoon and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Firstly, hollow microspheres of chitosan-polyacrylic acid were prepared. Dissolve 0.25 g of chitosan and 0.12 g of acrylic acid in 25 mL of distilled water. After they are completely dissolved, the temperature is raised to 80° C., and 0.05 g of potassium persulfate is added to initiate the polymerization of acrylic acid. When the system appears milky white, the system is cooled to room temperature, and then the glutaraldehyde of 0.1 mL is added to selectively cross-link chitosan to obtain the emulsion of chitosan-polyacrylic acid hollow microspheres, which can be referred to the applicant's Prior application.

[0022] Take the newly prepared chitosan-polyacrylic acid emulsion 2.5mL and mix it with an equal volume of 2M ammonia water, and let it stand for 48 hours. Dissolve 520 µl of tetraethyl orthosilicate in 2 mL of ethanol. The alkaline chitosan-polyacrylic acid emulsion was slowly added dropwise to the ethanol solution of tetraethylorthosilicate. Stir at room tem...

Embodiment 2

[0025] Take 2.5 mL of the newly prepared chitosan-polyacrylic acid emulsion, adjust the pH of the emulsion to 3 with 2M acetic acid, and let it stand for 48 hours. Dissolve 520 microliters of ethyl orthosilicate in 2 mL of ethanol. The acidic chitosan-polyacrylic acid emulsion was slowly added dropwise to the ethanol solution of tetraethylorthosilicate. Stir at room temperature for 24 hours, then place it at 50° C. for 24 hours, filter and centrifuge to obtain chitosan-silicon dioxide composite hollow microspheres.

[0026] The chitosan-silicon dioxide composite hollow microspheres in the above system are observed by a transmission electron microscope as a relatively regular spherical structure with an average particle diameter of 110nm and can exist stably in a wide range of pH values.

Embodiment 3

[0028] Take the newly prepared chitosan-polyacrylic acid emulsion 2.5mL and mix it with an equal volume of 2M ammonia water, and let it stand for 48 hours. Dissolve 520 microliters of ethyl orthosilicate in 2 mL of ethanol. The alkaline chitosan-polyacrylic acid emulsion was slowly added dropwise to the ethanol solution of tetraethylorthosilicate. Stir at room temperature for 24 hours, then place it at 50° C. for 24 hours, filter and centrifuge to obtain chitosan-silicon dioxide composite hollow microspheres. The product was washed several times, dispersed in distilled water, frozen, and then freeze-dried in a lyophilizer. Take 15 mg of freeze-dried chitosan-silicon dioxide composite hollow microsphere powder and a certain quality of doxorubicin hydrochloride and mix them in distilled water, stir at room temperature for 48 hours, centrifuge and wash three times, remove the upper liquid to obtain loaded doxorubicin hydrochloride chitosan-silica composite microspheres.

[002...

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Abstract

The invention relates to a chitosan-silicon dioxide compound hollow microballoon, tetraethoxysilane is poly-condensed and deposited on the surface of a chitosan-polyacrylic acid microballoon through hydrolyzation, so as to obtain the chitosan-silicon dioxide compound hollow microballoon with macro pore and meso pore structures, the average grain diameter is 50-200nm, wherein the molecular weight of chitosan is 10000-200000, and deacetylation is 70-95 percent.

Description

Technical field: [0001] The present invention relates to the preparation of organic-inorganic composite nanomaterials and the application field of drug release, in particular to a preparation method of chitosan-silicon dioxide composite nano hollow microspheres with macropores and mesoporous materials, as well as carrier and molecular sieve for drug release Applications. technical background: [0002] Since the 1960s, the controlled release of drugs and the targeted drug delivery in the human body have been a research hotspot in the fields of chemistry, medicine and pharmacy. Compared with the traditional drug administration mode, the controlled release of drugs has many advantages, such as: (1) the concentration of the drug released into the environment is relatively stable; (2) the drug can be used very effectively, so that it has a high utilization rate (3) It can make the release of the drug as close as possible to the lesion site, which improves the efficacy of the dru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02C07K17/00C07K14/80C07K14/765C07K1/14
Inventor 胡勇闫尔云蒋锡群丁寅王雪
Owner NANJING UNIV
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