9results about "Cytochromes" patented technology

To provide recombinant adeno-associated viral vectors for treating Bietti Crystalline Dystrophy.SOLUTION: Provided are a recombinant adeno-associated vector comprising a codon-optimized sequence encoding CYP4 V2 linked to predetermine gene expression regulatory sequences, and its use in treating Bietti Crystalline Dystrophy (BCD).SELECTED DRAWING: None

The disclosure relates to transcription cassettes, expression vectors and microbial cells adapted for the expression of genes regulated by the RBA transcription factor.

A polypeptide comprising a residue substituted by a non-canonical amino acid (ncAA) is provided. Methods for: (a) transferring an electron to an electrode, by coupling the polypeptide to an electrode; and (b) quantifying the amount of an analyte e.g., glucose are also provided.

The present disclosure relates to recombinant engineered polypeptides with cytochrome P450 (CYP) activity capable of selectively catalyzing the conversion of precursor compounds, carvacrol and / or thymol, to the product compound, thymohydroquinone (THQ), and recombinant host cells that heterologously express genes encoding these polypeptides (e.g., in yeast) and that can be used for enhanced fermentative bioproduction of the product compound THQ.

The present invention relates to a method for treating, preventing, or reducing a disease or disorder, e.g., hypertension, in a subject in need thereof. In embodiments, the method comprises co-administering to the subject an effective amount of a cytochrome P4503A4 (CYP3A4) inhibitor, an effective amount of a nitric oxide (NO) potentiator, and an effective amount of a phosphodiesterase-5 (PDE5) inhibitor. In some embodiments, the CYP3A4 inhibitor and the NO potentiator are the same compound.

The application belongs to the technical field of metal organic framework (MOF) immobilized enzyme, and particularly relates to a method for wrapping enzyme by seed orientation and application thereof. The application discloses a method for synthesizing enzyme@MOF composite by seed orientation, and based on the characteristics of MOF crystal growth, the seed orientation synthesis method is innovatively proposed. The addition of seed can greatly promote the synthesis efficiency of enzyme@MOF composite and greatly increase the encapsulation efficiency of enzyme. Meanwhile, the seed orientation synthesis method has no requirement on the chemical properties of enzyme / protein, and does not need to destructively modify the enzyme / protein to improve the encapsulation efficiency, so that the seed orientation synthesis method has good universality. The seed orientation synthesis method solves the problems of low universality and low efficiency in the existing enzyme@MOF composite synthesis method, and has an expected application prospect in the fields of biological catalysis, biological sensing, biological medicine and the like.

Particles comprising a protein and optionally an activator, for example, particles comprising whey protein hydrolysate and optionally tryptophan, are described herein. Methods for preparing and using particles comprising a protein and optionally an activator are also described herein.

A nanowire may be isolated from a bacterium, wherein the nanowire includes c-type heme subunits or pili proteins and is capable of establishing an electrical connection with an insoluble electron acceptor. The c-type heme subunits may comprise OmcS or OmcZ cytochrome subunits or any combination thereof. The pili proteins may have an amino acid sequence with at least one residue modified, from a wild-type strain of the microorganism, to include an aromatic amino acid. The nanowire may have metallic or semiconducting conductive properties, and may be integrated into an electronic device.