Transdermal administration composite containing cucurbitacin-type active ingredient

A technology of active ingredients and cucurbitacins, applied in the field of medicine, can solve problems such as drug absorption disorder, affecting effective blood drug concentration, etc., and achieve the effect of good compliance
CN101623286AActive Publication Date: 2010-01-13SHENYANG PHARMA UNIVERSITY
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
SHENYANG PHARMA UNIVERSITY
Publication Date
2010-01-13

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Abstract

The invention relates to a transdermal administration composite containing cucurbitacin-type active ingredient. The transdermal transparent accelerator in the transdermal administration preparation of the cucurbitacin-type active ingredient is one or more composites of oleic acid, azone, eucalyptus oil, or isopropyl myristate and the like, and the dosage of the transdermal transparent accelerator is 0.1 to 50%, and 0.3 to 30% is preferred. The transdermal administration of cucurbitacin-type active ingredient can adopt liquid or semisolid preparation of gels, emulsion, ointment, solution agent, micro-emulsion, ethosomes or nebula and the like, or emplastrum such as patch, cataplasma and the like. After the transdermal administration of the preparations, the active ingredient can be absorbed by skin continuously and enter into human body to play a therapeutic role for a long while, the patient adaptability is significantly better than oral administration medication, therefore, the transdermal administration composite can be used for preventing and curing of hepatitis, cancer and other diseases and improving quality life of patients.
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Description

technical field

[0001] The invention relates to the technical field of medicine, relates to a transdermal composition containing cucurbitacin active ingredients, in particular to a transdermal composition for preventing or treating hepatitis or cancer. Background technique

[0002] It has been reported in the literature that cucurbitacin components have multiple therapeutic activities, among which multiple components have cytotoxicity, hepatoprotective effect, anti-inflammatory effect, cardiovascular effect and antidiabetic effect (seeing Jayaprakasam B, et al., Anticancer and anti -Inflammatory activities of cucurbitacins from Cucurbita andreana. Cancer Lett, 2003, 189: 11-16. and Yesilada E, et al., Isolation of ananti-inflammatory principle from the fruit juice of Ecballium elaterium. J NatProd, 1988, 51: 504- 508.). In recent years, research reports have confirmed that: cucurbitacin B, D, E and I can inhibit the growth of some cancer cell lines, and inhibit cyclooxygena...

Claims

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