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Application of PEG-PCL-PEG triblock copolymer in preparation of medical anti-adhesion material

A copolymer and anti-adhesion technology, which is applied in the field of tri-block copolymers to prepare medical anti-adhesion materials, can solve the problems of poor anti-adhesion effect, unfavorable human safety, difficult transportation and storage, etc., and achieves outstanding comprehensive performance and low cost , the effect of easy preparation

Inactive Publication Date: 2010-03-17
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, other medical materials that can be used are either prepared after being dissolved in an organic solvent, which is not conducive to human safety; or the anti-adhesion effect is not good, and the price is expensive, which is difficult to transport and store

Method used

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  • Application of PEG-PCL-PEG triblock copolymer in preparation of medical anti-adhesion material
  • Application of PEG-PCL-PEG triblock copolymer in preparation of medical anti-adhesion material
  • Application of PEG-PCL-PEG triblock copolymer in preparation of medical anti-adhesion material

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Experimental program
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Effect test

Embodiment 1

[0045] Synthesis and verification of embodiment 1 PEG-PCL-PEG copolymer

[0046] 1) Synthesis of PEG-PCL-PEG copolymer

[0047] The synthetic reaction of PEG-PCL-PEG copolymer of the present invention is as Image 6 Shown:

[0048] Where X and Y are both positive integers.

[0049] According to the synthetic route of above formula, add a certain amount of polyethylene glycol monomethyl ether (MPEG) and ε-caprolactone (ε-CL) in the there-necked flask that stirrer is equipped with, take stannous octoate as catalyst, in React for 6 hours at 130°C under nitrogen protection, cool down to 80°C, add crosslinking agent isophorone diisocyanate (IPDI) and continue to react for 6 hours to obtain the product, cool to room temperature for purification, and dry. In addition, suitable diisocyanates include: toluene diisocyanate, hexamethylene diisocyanate (HMDI), L-lysine ethyl ester diisocyanate (LDI, lysine ethyl ester diisocyanate), diphenylmethane-4,4' - Diisocyanates, etc. When car...

Embodiment 2

[0060] Embodiment 2 uses PEG-PCL-PEG copolymer to prepare medical anti-adhesion material

[0061] Use the PEG-PCL-PEG copolymer prepared by the above-described embodiment to prepare a medical anti-adhesion material: first make E 550 -C 2200 -E 550 Dissolve in physiological saline, the concentration is 15-40wt%, the preferred concentration is 25wt%, fully stirred, and mixed evenly. The mixed physiological saline solution was heated and stirred at 50°C for about 5 minutes to form a translucent viscous liquid, which was cooled to below 4°C for use. There are two methods of use: a: inject the sol-like hydrogel around the wound, and form a gel by increasing the temperature. B: The sol-like hydrogel is refrigerated at below 4°C for more than 24 hours. Through crystallization, the hydrogel is completely gelled. When applied, it is directly applied to the wound surface of the abdominal cavity. Considering the convenience of use and storage, we choose to adopt the second method, th...

Embodiment 3

[0062] Embodiment 3 Anti-adhesion effect experiment of medical anti-adhesion material of the present invention

[0063] The hydrogel is applied as an anti-adhesion barrier. The specific method is to dissolve the copolymer prepared in Example 2 in physiological saline, prepare a 25wt% solution, and then refrigerate the sol-like hydrogel for more than 24 hours at below 4°C. Through crystallization, the hydrogel After the gelation is completed, when applying, directly spread the gel evenly around the wound in the abdominal cavity.

[0064] 1. Abdominal wall-cecum friction injury model: anesthetize the animal, open the abdomen, rub the cecum with dry gauze, damage the surface serosa layer, and peel off the serosa layer with a scalpel on the adjacent abdominal wall (mouse: 1×1cm; large Rat: 2X2cm). Then apply PEG-PCL-PEG hydrogel (mice: 0.2ml; rats: 1ml) on the injured surface evenly, and close the abdominal cavity.

[0065] The following mainly through E 550 -C 2200 -E 550 T...

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Abstract

The invention relates to the field of medical high polymer materials, and in particular to an application of triblock copolymer in preparation of medical anti-adhesion material. The invention aims tosolve the technical problem of providing a new choice for medical anti-adhesion material, and has the technical scheme of providing the application of PEG-PCL-PEG triblock copolymer in preparation ofmedical anti-adhesion material, wherein the molecular weight of the PEG-PCL-PEG copolymer is from 1500 to 10000, the ratio of the molecular weight of the PEG chain to the molecular weight of the PCL chain is 0.4 to 2.6; and the triblock copolymer can be dissolved in water to form a solution and form gel after reaching a certain intensity. Experiments prove that water gel of the PEG-PCL-PEG triblock copolymer has many good characteristics, and provides a new choice for the field of medical anti-adhesion materials.

Description

technical field [0001] The invention relates to the field of medical polymer materials, in particular to the use of a water-soluble, gel-forming biodegradable tri-block copolymer in the preparation of medical anti-adhesion materials. Background technique [0002] Postoperative adhesion is a difficult problem that has not been solved for a long time in the field of surgery. So far people are looking for various methods to prevent postoperative adhesions, but the clinical effects of the current technical solutions are not satisfactory, and it is difficult to meet the ideal clinical requirements. In recent years, it has become a common practice in the world to prevent postoperative adhesions by implanting isolation materials in areas prone to postoperative adhesions. Anti-adhesion film, anti-adhesion gel, anti-adhesion liquid, etc., the above materials have their own advantages, but also have their shortcomings. People hope to develop a kind of easy-to-use anti-adhesion gel s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/765A61P41/00A61L31/06
Inventor 钱志勇魏于全赵霞
Owner SICHUAN UNIV
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