Preparation method of human serum albumin nano granules coated with oxaliplatin
A technology of human albumin and oxaliplatin, which is applied in the field of preparation of human albumin nanoparticles, can solve the problem of increased toxicity and side effects of non-target organ tissues in the whole body, poor performance of tissue deposition and lymphatic guidance, and undetectable performance. Drugs and other issues to achieve the effect of increasing tumor targeting, improving drug release, and increasing volume and quality
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[0026] The human albumin nanoparticle carrying oxaliplatin of the present invention is composed of oxaliplatin crude drug and human albumin HSA, and water for injection, absolute ethanol, glutaraldehyde and sodium hydroxide are used in the preparation process. Wherein: the mass ratio of oxaliplatin crude drug and albumin is 20%, the concentration of albumin aqueous solution is 2%, the volume ratio of precipitating agent dehydrated alcohol and albumin aqueous solution is 2.5: 1; The molar ratio of amino groups to albumin was 100%, and the concentration of sodium hydroxide was 1M.
[0027] Its preparation is prepared through the following steps:
[0028] (1) Direct drug loading and precipitation:
[0029] Weigh 200 mg of HSA and 20 mg of oxaliplatin, prepare a 2% albumin solution with pure water, adjust the pH to 9.0 with 1M sodium hydroxide, add 25 mL of anhydrous Ethanol, to obtain blue opalescent colloidal solution, continue to stir;
[0030] (2) Adsorption drug loading an...
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