18 results about "Lymph circulation" patented technology

The invention belongs to the technical field of medicines, and particularly provides a solid dispersion as well as a preparation method and application thereof. The solid dispersion comprises a carrier material, and further comprises quercetagetin and phospholipid, the mass ratio of the quercetagetin to the phospholipid is 1: (0.3-1.5), and the carrier material comprises one or more of a hydrophilic polymer and a pH-dependent polymer. Wherein the quercetagetin and the phospholipid are combined through an intermolecular force, so that the quercetagetin obtains a lipid material similar to a cell membrane structure, a cell membrane bionic phospholipid compound is formed, the cell membrane bionic phospholipid compound can be naturally compatible with an upper wall cell membrane of a small intestine, and the permeation transmembrane capability of the quercetagetin is better promoted; the quercetagetin is added into the solid dispersion, so that more quercetagetin can enter systemic circulation and lymphatic circulation, and therefore, the solid dispersion can strengthen transmembrane absorption while strengthening dissolution, so that the solid dispersion has high bioavailability.

The invention discloses an electrical stimulation lymphedema rehabilitation device, and relates to the technical field of lymphedema rehabilitation, and the device comprises a housing, and also comprises an electrical stimulation mechanism which is installed at the top of the housing and comprises a plurality of electrode plates; the limb supporting mechanism is installed on the two sides of the shell and comprises a first lantern ring and a second lantern ring; the multi-section massage mechanism is installed in the shell and comprises a plurality of air bags, and one side of each air bag is communicated with an electromagnetic valve; the uniform pressing mechanism is connected with the multi-section massage mechanism and comprises a downward moving anti-sticking mechanism and a translation switching mechanism; the electrical stimulation mechanism further comprises a controller fixed to the top of the shell, and the controller is electrically connected with the multiple electrode slices. By installing the uniform pressing mechanism, uniform massage is achieved, the pressing position of the air bag is changed, the whole limb is pressed uniformly, the pressing strength of all parts of the limb is prevented from being different, the problem that the whole limb is pressed unevenly is effectively solved, and therefore lymph circulation is more efficiently promoted.

The invention belongs to the technical field of organ cores, and provides a brain lymphatic circulation reflux system multi-organ cascade chip model construction method and a model, and the method comprises the following steps: adjusting the size of a channel inlet and outlet of a brain lymphatic chip to be consistent with the size of a middle channel inlet of a meningeal lymphatic chip; the size of an outlet of a middle channel of the meningeal lymphatic vessel chip is adjusted to be consistent with the size of an inlet of a channel of the deep cervical lymph node chip; corresponding outlets and inlets of the brain lymphatic chip, the meningeal lymphatic vessel chip and the deep cervical lymph node chip are communicated through catheters, series connection of the three chips is achieved, the flowing process is consistent with the cerebrospinal fluid lymphatic circulation backflow process, and the blank that the cerebrospinal fluid lymphatic circulation backflow process cannot be achieved in vitro before is filled up. Moreover, the brain lymphatic chip, the meningeal lymphatic vessel chip and the deep cervical lymph node chip are cascaded to one substrate, so that the actual sizes of the three chips are reduced, and the cascade operation of multiple chips is more convenient.

The present disclosure relates to an apparatus and method for early evaluation of lymphedema occurrence by determining the regularity of lymphatic contractions, the apparatus comprising a memory for storing at least one instruction for early evaluation of lymphedema occurrence, and a processor for performing operations according to the instruction, wherein the processor: monitors, by using indocyanine green lymphography, the occurrence of lymphedema in an animal model in which lymph nodes have been resected to disconnect lymphatic circulation in an upper limb from the proximal region; measures lymphatic contraction signals at a distal site to detect the onset of and changes in lymphatic circulation disorder; compares the measured lymphatic contraction signals with the lymphatic contraction signals from a normal site; monitors changes in the lymphatic contraction signals at the distal site; and determines the presence of lymphedema on the basis of the monitoring results.

The utility model provides a lymphedema foot and finger-toe pressure treatment device through simulation manipulation, and relates to the technical field of medical care tools, the lymphedema foot and finger-toe pressure treatment device comprises a toe cavity and a foot cavity, the foot cavity comprises a foot sleeve body and a first air bag body, a zipper is connected between the two ends of the foot sleeve body, and the first air bag body is connected with the toe cavity. The first air bag bodies are arranged in an interlayer of the foot sleeve body, the multiple sets of first air bag bodies are arranged and are independent from one another, and a first inflation connector is arranged on one side of the foot sleeve body; the foot cavity and the toe cavity which are specially used for foot and toe treatment are designed, during use, the foot sleeve body is arranged on the outer side of a foot in a surrounding and sleeving mode, the toe sleeve body is arranged on the outer side of a toe in a sleeving mode, and the first air bag body and the second air bag body are inflated and deflated by connecting the first air bag body and the second air bag body through the first air guide pipe and the second air guide pipe. Therefore, refined lymphedema pressure treatment is carried out on the feet and the fingers and toes, and lymphatic circulation of the feet and the fingers and toes is improved.

The present invention relates to a human implant for inducing regeneration of body vessels and a method for treating lymphedema or ischemic diseases using the same. The structure of the present invention not only provides appropriate physical strength and mechanical support to prevent re-injury of body vessels such as lymphatic vessels or blood vessels during regeneration, but also structurally and functionally mimics in vivo body vessel tissue by promoting the flow of body fluids through capillary action using a simple rod structure with irregularities (e.g., H-beams) or lumens (e.g., tubular). Furthermore, the structure of the present invention is implanted into the lesion and decomposes at an appropriate time after the completion of body vessel regeneration, making it useful as an efficient treatment for various pathological conditions caused by blocked lymphatic flow or reduced blood flow.

The invention discloses a knee joint fixing brace and a using method thereof, and belongs to the technical field of medical instruments, the knee joint fixing brace comprises a thigh fixing support and a shank fixing support, air bags are arranged on the inner side walls of the thigh fixing support and the shank fixing support, the air bags are connected with an external pressure pump through air pipelines, and air pressure valves are arranged on the air pipelines; the thigh fixing support and the shank fixing support are connected together through a connecting assembly to form a cylindrical structure, an upper connecting rod is arranged on the outer side wall of the thigh fixing support, a lower connecting rod is arranged on the outer side wall of the shank fixing support, and the upper connecting rod and the lower connecting rod are connected together through a hinge assembly. Gradient pressure changes are applied to limbs, the limbs are regularly inflated and deflated, the effect similar to muscle contraction and relaxation is generated, blood backflow and lymph circulation are promoted, blood supply of local tissue is improved, blood circulation is promoted, edema is relieved, and the risk of lower limb deep vein thrombosis is reduced.

The invention discloses a magnetic resonance imaging method for measuring the volume fraction of periarterial space cerebrospinal fluid with heart rate activity. The method comprises the steps that brain magnetic resonance images are collected, and meanwhile the time sequence of pulse signals is collected; the brain magnetic resonance image corresponds to the pulse signal period, and a plurality of pieces of magnetic resonance image data at equal intervals in the pulse signal period are generated; segmenting a lateral ventricle region in the brain magnetic resonance image, and calculating the CSF average signal intensity of cerebrospinal fluid in the lateral ventricle region; calculating a peak value and a valley value of a magnetic resonance signal time sequence one by one pixel or in an interested area to obtain a signal fluctuation change magnetic resonance signal difference value; dividing the magnetic resonance signal difference value of the signal fluctuation change by the average signal intensity of the lateral ventricle cerebrospinal fluid CSF to obtain the volume fraction caPVS of the periarterial space cerebrospinal fluid. The perivascular space cerebrospinal fluid volume fraction calculated by the method can effectively reflect perivascular space participating in lymphatic-like circulation, and the influence of pathological perivascular space such as expanded perivascular space is eliminated.

In methods for treating a patient, a time varying magnetic field is applied to a patient's body and causes a muscle contraction. The time-varying magnetic field may be monophasic, biphasic, polyphasic and / or static. The method may reduce adipose tissue, improve metabolism, blood and / or lymph circulation. The method may use combinations of treatments to enhance the visual appearance of the patient.

The invention discloses a lymphedema rehabilitation system and method based on multi-modal integration, relates to the technical field of rehabilitation assistance, and has the technical key points that the rehabilitation system and method greatly improve the treatment effect by virtue of multiple innovative functions. According to the invention, accurate synchronization and deep complementation of infrared thermal imaging evaluation, audio nerve regulation, meridian mechanical stimulation and pressure treatment are realized, and the synergistic interaction characteristic of each treatment mode is fully embodied; by means of the infrared thermal imaging technology, the lymphatic circulation abnormal part is accurately recognized, the autonomic nerve state is adjusted through guiding audio, and the physiological function and the psychological emotion can be optimized at the same time in cooperation with targeted meridian intervention and pressure therapy, so that the physical and psychological health is effectively promoted, the scientificity and pertinence of treatment are remarkably enhanced, and the treatment cost is reduced. And the accuracy and individuation of the treatment effect are ensured.

The utility model discloses a pair of pressure-adjustable gloves, which belongs to the technical field of medical instruments and comprises glove bodies, finger bandages are integrally formed outside the glove bodies, first connecting cloth is sewn outside the glove bodies, second connecting cloth is sewn outside the finger bandages, and the first connecting cloth and the second connecting cloth are integrally formed. The glove comprises a glove body, finger bandages are arranged on the glove body, the finger bandages are arranged on the glove body, two first ring bands are sewn on the outer portion of the glove body, two first elastic bands are sewn on the outer portion of the glove body, and first through holes are formed in the outer portions of the first ring bands. Then the first elastic band and the second elastic band are adjusted to penetrate through the first ring band and the second ring band, then the hook face of the hook-and-loop fastener is connected with the loop face of the hook-and-loop fastener to complete fixation, certain pressure is generated to promote lymph circulation, accumulation of the lymph in tissue is reduced, accordingly, edema of the affected limb is effectively relieved, and better self-nursing of the patient at home can be helped.

The invention discloses a cRGD / PDA co-modified dihydroartemisinin prodrug liposome as well as a preparation method and application of the cRGD / PDA co-modified dihydroartemisinin prodrug liposome. The liposome comprises a polydopamine (PDA) shell, a cRGD target head and a dihydroartemisinin prodrug containing a disulfide bond. The preparation method comprises the following steps: synthesizing a dihydroartemisinin prodrug with reduction sensitivity through cyclization reaction of dithiodipropionic acid; dissolving the prodrug and auxiliary materials, and injecting into a water phase to form liposome; the lipidosome is wrapped through PDA self-deposition; and modifying with the cRGD peptide to obtain the dihydroartemisinin prodrug liposome. The disulfide bond dihydroartemisinin prodrug carried in the liposome has GSH and pH sensitivity at the same time, the lipid solubility of the drug is effectively enhanced, the defect of low drug loading capacity of a nano preparation is overcome, oral administration can be met, and dihydroartemisinin is triggered and released in plasmodium. The cRGD modified lipidosome with stable gastrointestinal tracts can specifically target intestinal M cell mediated lymphatic circulation, promote the lipidosome to be transferred into blood through lymph, reduce liver-intestine first-pass metabolism and improve the oral curative effect.

The application belongs to the technical field of organ chip, and proposes a brain lymphatic circulation reflux system multi-organ cascade chip model construction method and model, which adjusts the size of the channel inlet and outlet of the brain lymphoid chip to be consistent with the size of the middle channel inlet of the meningeal lymphatic chip; adjusts the size of the middle channel outlet of the meningeal lymphatic tube chip to be consistent with the size of the channel inlet of the deep cervical lymph node chip; uses a catheter to connect the corresponding outlets and inlets of the brain lymphoid chip, the meningeal lymphatic tube chip and the deep cervical lymph node chip, realizes the series connection of the three chips, the flow process is consistent with the cerebrospinal fluid lymphatic circulation reflux process, fills the gap that the cerebrospinal fluid lymphatic circulation reflux process cannot be realized in vitro before; and the brain lymphoid chip, the meningeal lymphatic tube chip and the deep cervical lymph node chip are cascaded on one substrate, the actual size of the three chips is reduced, and the cascade operation of the multi-chip is more convenient.

In methods for treating a patient, a time varying magnetic field is applied to a patient's body and causes a muscle contraction. The time-varying magnetic field may be monophasic, biphasic, polyphasic and / or static. The method may reduce adipose tissue, improve metabolism, blood and / or lymph circulation. The method may use combinations of treatments to enhance the visual appearance of the patient.

The utility model provides a finger and palm pressure treatment device for lymphedema through simulation manipulation, which relates to the technical field of medical care tools, and comprises a palm sleeve and a finger sleeve, a plurality of groups of first air bag cavities are arranged in the palm sleeve, a first joint extending out of the palm sleeve is arranged above the first air bag cavities, and a second joint extending out of the finger sleeve is arranged above the first air bag cavities. The first connector is connected with a first air guide pipe; a second air bag cavity is formed in an inner interlayer of the finger stall, and a second connector is arranged on one side of the finger stall. The palm sleeve and the finger sleeves which are specially used for palm and finger treatment are designed, during use, the palm sleeve is arranged on the outer side of a palm in a surrounding and sleeving mode, the finger sleeves are arranged on the outer sides of fingers in a sleeving mode, the first air guide pipe and the second air guide pipe are connected with the inflation and deflation pump main machine, and the first air bag cavity and the second air bag cavity are inflated and deflated; therefore, refined lymphedema pressure treatment is performed on the palm and the fingers, and lymphatic circulation of the palm and the fingers is improved.

The present patent relates to an innovative device for breast massage, incorporating temperature, blood circulation and tension sensors, designed to facilitate the early detection of breast cancer. The device can take the form of a wearable device or a garment, such as a bra, combining several key functions: gentle massage to stimulate blood and lymph circulation, thermal sensors to identify abnormal temperature variations, blood flow sensors to detect circulatory irregularities, and tension sensors to assess tissue changes. Thanks to its ergonomic, non-invasive design, this device aims to offer preventive home monitoring, personalized follow-up of breast parameters and complementarity with traditional screening methods. It is aimed at women wishing to monitor their breast health on a daily basis, as well as those requiring post-treatment follow-up. The device could also be connected to a digital platform for long-term data storage and analysis. This device represents a significant advance in the accessibility and improvement of early breast cancer detection tools, while offering comfort and discretion in use.

This disclosure relates to compression garments, specifically to compression garments to promote lymphatic circulation and / or circulation of other bodily fluids. The garments can include compression actuator units that can apply a pull force on a strap of the compression garment to apply compression to an anatomical feature of the user. The compression actuator units can be actuated via contraction of a wire made of shape memory material. The compression actuator units can include a plurality of levers to amplify the effect of the contraction of the wire to provide a wide range of compressive forces to the user.

The invention relates to the field of medical equipment, in particular to a lymphatic stimulation device and method based on BMI and meridians, a BMI parameter measurement and calculation module calculates a BMI value of a user by adopting bioelectrical impedance analysis, and obtains a corresponding user type based on the BMI value; the bioelectricity feedback module adopts an electrode array to detect the skin conductivity and the impedance change value of a target acupoint, and obtains a lymphatic cycle efficiency score in combination with a regression analysis model; the mode matching module is used for matching corresponding pressure and temperature stimulation modes based on the user type and the lymphatic cycle efficiency score; the negative pressure intensity adjusting module adjusts the negative pressure of the negative pressure suction head assembly based on the pressure stimulation mode; the temperature adjusting module adjusts the working temperature of the lymphatic vessel development head assembly based on the temperature stimulation mode. The traditional Chinese medicine composition has the capability of penetrating a fat layer, reduces inflammatory factors, improves metabolism of overweight patients, relieves edema and promotes lymphatic drainage.