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Medicine for treating peptic ulcer, preparation method and application thereof

A peptic ulcer and drug technology, applied in the field of combination drugs, can solve the problems of R&D and production being controlled by others, no independent intellectual property rights, etc., and achieve the effects of rapid pain relief, less recurrence, and high cure rate.

Inactive Publication Date: 2013-04-03
广东中大南海海洋生物技术工程中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such drugs are basically researched and developed by Western developed countries, and the products produced in my country are basically generic drugs without independent intellectual property rights. Further research and development and production are largely subject to human control
Simultaneously the limitation that this kind of western medicine exists aspect side effects, permanent cure

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Accurately weigh the following raw materials: Codonopsis 27, Liangmianzhen 27, Astragalus 13, Licorice 13, Magnolia officinalis 7, Tangerine peel 3, Atractylodes 9, Clove 1. Among them, the original medicinal materials of magnolia officinalis, atractylodes atractylodes, and cloves are crushed into coarse powder, and supercritical carbon dioxide (SFE-CO 2 ) extraction, the extraction parameters are extraction temperature 45°C, extraction pressure 26MPa, analysis pressure 6MPa, analysis temperature 40°C, carbon dioxide (CO 2 ) with a flow rate of 250 L / h and an extraction time of 3 hours. Add 2% (relative to the total weight of raw materials) β-cyclodextrin to the obtained fat-soluble ingredients, grind for 30 minutes, and put the mixture in a clean container for later use. Codonopsis pilosula, astragalus, licorice, tangerine peel and supercritical dregs are extracted with 8 times water for 3 times, each time for 1 hour, filtered, combined extracts, concentrated to a rela...

Embodiment 2

[0027] Accurately weigh the following raw materials: Codonopsis 400g, Liangmianzhen 400g, Astragalus 200g, Licorice 200g, Magnolia officinalis 100g, Chenpi 50g, Atractylodes 130g, Clove 20g. Among them, the original medicinal materials of magnolia officinalis, atractylodes atractylodes, and cloves are crushed into coarse powder, and supercritical carbon dioxide (SFE-CO 2 ) extraction, the extraction parameters are extraction temperature 45°C, extraction pressure 26MPa, analysis pressure 6MPa, analysis temperature 40°C, carbon dioxide (CO 2 ) with a flow rate of 250 L / h and an extraction time of 3 hours, add 30 g of β-cyclodextrin to the obtained fat-soluble components, grind for 30 minutes, and put the mixture in a clean container for later use. Codonopsis pilosula, astragalus, licorice, tangerine peel and supercritical dregs are extracted with 8 times water for 3 times, each time for 1 hour, filtered, combined extracts, concentrated to a relative density of 1.15 (50 ℃ thermal...

Embodiment 3

[0028] Embodiment three: Pharmacodynamic research

[0029] During the experiment, the animals were randomly divided into groups, and the normal or model group was set as the blank control group, and Xiangsha Liujun Pill, which was basically similar in efficacy to the main treatment, was selected as the positive drug control. Shu Capsules, Ranitidine, Gypenoside Tablets and Buzhong Yiqi Pills were used as positive drug controls to ensure the reliability of the test method. Three dosage groups were set up respectively according to 5 times, 10 times, 20 times (rats) or 10 times, 20 times, 30 times (mice) of the clinical dose of the tested drug.

[0030] Test result shows: medicine of the present invention can obviously suppress water immersion stress, pyloric ligation, reserpine and acetic acid (chronic) cause gastric ulcer in rats; It has obvious inhibitory effect; it has the effect of increasing the pH value of gastric juice and pepsin activity; it can significantly reduce the...

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PUM

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Abstract

The invention relates to a traditional Chinese medicine compound preparation for treating peptic ulcer, a preparation method and an application thereof. The medicine for treating the peptic ulcer comprises powder for normalizing the stomach and a compound preparation, wherein the powder for normalizing the stomach comprises rhizoma atractylodis, officinal magnolia, tangerine peel and licorice, and the compound preparation comprises the medicines of radix codonopsis pilosulae, astragalus root, radix zanthoxyli, clove and the like. The medicine has the effects of promoting the circulation of qi, alleviating pain, nourishing the stomach and strengthening the spleen, is used for treating gastric and duodenal ulcer, has the advantages of quick acting, short time, no relapse after recovering, no toxic or side effect, convenient use and simple preparation process and has unique curative effect in the aspect of treating the peptic ulcer, and a patient with the gastric and duodenal ulcer belongs to a person with dampness obstruction, qi stasis and the weakness of the spleen and the stomach by the differentiation of symptoms and signs through the traditional Chinese medicine.

Description

technical field [0001] The invention relates to a combination medicine, in particular to a combination medicine for treating peptic ulcer, as well as its preparation method and application. Background technique [0002] Peptic ulcer mainly refers to chronic ulcers that occur in the stomach and duodenum, namely gastric ulcer and duodenal ulcer, which are named after the occurrence and formation of ulcers are related to the digestion of gastric acid-pepsin. The symptoms at the beginning of the onset are similar to those of functional dyspepsia. Later, in severe cases, abdominal pain, melena, hematemesis, etc. may occur, and complications such as hemorrhage, pyloric infarction, perforation, etc. may occur, and a small number of peptic ulcers may even cause cancer. Peptic ulcer is a global common and frequently-occurring disease, and it is also a chronic disease that easily recurs. So far, there is no effective means for a complete cure. Statistical analysis shows that the inci...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61K9/48A61P1/04
Inventor 徐安龙荆琛峰王瑞梁东卢炼钢
Owner 广东中大南海海洋生物技术工程中心有限公司