Creatine phosphate sodium oral solid preparation and preparation method thereof
A technology of sodium phosphocreatine phosphate and solid preparation, which is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations with inactive ingredients, etc. To reduce the loss, improve myocardial ischemia and hypoxia, and achieve good stability
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specific Embodiment approach 1
[0020] Embodiment 1: Sodium creatine phosphate oral solid preparation of this embodiment is composed of 204-206g of sodium phosphate phosphate, 41-43g of starch, 27-29g of sodium starch glycolate, 59-61g of microcrystalline cellulose and 5 ~7g of absorption enhancer is made into sodium phosphate oral enteric-coated capsule; wherein the absorption enhancer is L-glutamine, sodium lactate, d-potassium hydrogen tartrate or vitamin B 1 .
specific Embodiment approach 2
[0021] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the sodium creatine phosphate oral solid preparation is composed of 205g of sodium creatine phosphate, 42g of starch, 28g of sodium starch glycolate, 60g of microcrystalline cellulose and 6g of The absorption enhancer is made into sodium phosphate creatine oral enteric-coated capsules. Others are the same as the first embodiment.
[0022] Experiment of the protective effect of sodium creatine phosphate oral solid preparation on skeletal muscle in the present embodiment:
[0023] 1. Experimental animals, feeding conditions and grouping
[0024]1.1 45 healthy adult male SD rats, weighing 190-200g;
[0025] 1.2 The rats were raised in large plastic cages, 5 per cage, and the cages were equipped with stainless steel cages, glass suction bottles and stainless steel suction pipes; the room temperature was about 20 °C, and the relative humidity was 55%-75%; the feed was standard mixed rat diet , f...
specific Embodiment approach 3
[0056] Embodiment 3: The method for preparing sodium creatine phosphate oral solid preparation in this embodiment is implemented according to the following steps: 1. Weigh 204-206 g of sodium creatine phosphate, 41-43 g of starch, and 27-29 g of sodium starch glycolate , 59~61g of microcrystalline cellulose and 5~6g of absorbent; 2. Put the weighed starch, sodium starch glycolate and microcrystalline cellulose at 105°C and dry for 1.5h respectively, and then weigh the The sodium phosphate creatine, the absorbent, the dried starch, the dried sodium starch glycolate and the dried microcrystalline cellulose were passed through a 100-mesh sieve respectively; three, the sieved raw materials were added to the Mixing in the mixer for 15min, then filling the hollow enteric-coated capsules according to the average content weight of 0.335±0.02g to obtain sodium creatine phosphate oral enteric-coated capsules; wherein in step 1, the absorption enhancer is L-glutamine, Sodium lactate, pot...
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