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A kind of extract and preparation method of southern yew leaves

A technology of southern yew and extract, which is applied in the direction of drug combination, medical raw materials derived from gymnosperm subphylum, cardiovascular system diseases, etc., and can solve the problems of non-selective extraction of target compounds, large industrial pollution, and long extraction time , to achieve the effect of benefiting angina pectoris, short extraction time and high extraction rate

Inactive Publication Date: 2012-02-01
宁波泰康红豆杉生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional extraction methods have defects such as long extraction time, complicated process, low efficiency, large industrial pollution and no selectivity for the extraction of target compounds.

Method used

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  • A kind of extract and preparation method of southern yew leaves

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0023] Taking SD rats as the experimental object, giving the extract 4.4g (crude drug) / kg (mouse) in the above-mentioned embodiment every day is the administration group, dissolves with physiological water and administers it by gavage, after 7 days, it is compared with the matched group (normal saline). Equal-volume gavage for 7 days) At the same time, blood was taken from the vein, with adenosine diphosphate sodium salt (ADP) as the inducer, the platelet aggregation percentage of each group was measured according to the Born turbidimetry, and the heart blood was taken at the same time, and formed on the thrombosis instrument. Thrombus, the results showed that compared with the control group, the 1min platelet aggregation rate was significantly reduced in the treatment group, the difference was statistically significant (P<0.05), and the thrombus length was also significantly shortened (P<0.05). It shows that the extract can effectively inhibit ADP-induced platelet aggregation ...

experiment example 2

[0025] Take rats as the experimental object, give the extract 4.4g (crude drug) / kg (mouse) in the above-mentioned embodiment every day as the administration group, dissolve it with physiological water and administer it by gavage, after 8 days, compare with the control group (normal saline, etc.) Volumetric gavage for 8 days) simultaneously injected epinephrine and calcium chloride to induce arrhythmia, and the results showed that compared with the control group, the administration group had significantly antagonizing arrhythmia effect (P<0.05). In the experiment on the effect on heart function, it was found that the intravenous injection of the extract can significantly antagonize the effect of norepinephrine on raising blood pressure, and has a certain rebound effect on the lowering of blood pressure caused by histamine, among which LVEDP, BP indicators were significantly reduced, but HR had no significant change. This effect is to reduce arterial blood pressure and left ventr...

experiment example 3

[0027]Taking the dog as the experimental object, giving the extract 4.4g (crude drug) / kg (dog) in the above-mentioned embodiment and dissolving the gavage administration with physiological water is the administration group, and the equal-volume normal saline gavage is the control group, after gavage The left circumflex coronary artery was isolated from the treatment group and the control group at the same time, and the coronary blood flow was measured by the MFV-110 electromagnetic flowmeter probe to calculate the coronary resistance, and the myocardial oxygen consumption was measured by the Unistat oximeter. The results showed that the myocardial oxygen consumption and oxygen consumption index of the administration group decreased significantly at 5 minutes, and the myocardial oxygen consumption decreased most significantly at 45 minutes after administration, which was significantly different from that before administration and the control group (P<0.01 and (P <0.001), indicat...

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Abstract

The invention discloses an extract of southern yew leaves and a preparation method. The extract is a light yellow powder, and the powder contains taxoflavone with a weight content of 65-70%, and the taxoflavone includes the following five components : 3-O-rutin-quercetin, 3-O-rutin-kaempferol, 3-O-rutin-myricetin, 7-O-glucose-kaempferol and 7-O-glucose-quercetin , the total weight content of the above five ingredients in taxane flavonoids is 40-60%. The extract uses fresh southern red bean leaves as raw materials, which are dried, crushed and sieved, immersed in ethanol solvent, ultrasonically extracted under stirring, and the extract It is prepared by the preparation method of decompression and concentration to remove alcohol, chloroform extraction and degreasing, and water phase concentration and drying; the present invention is a treatment and health care for cardiovascular system diseases with the functions of improving cardiac microcirculation, anti-arrhythmia, reducing myocardial oxygen consumption, etc. The extract of southern yew leaves has the advantages of low energy consumption, short extraction time, less impurities and high extraction rate.

Description

technical field [0001] The invention relates to plant effective components and extraction technology, in particular to an extract of southern yew leaves and a preparation method. Background technique [0002] Paclitaxel isolated from the genus Taxus is the first effective natural anticancer drug. Paclitaxel has been widely used in the clinical treatment of various tumors and has attracted more and more attention from all over the world. In addition to paclitaxel, the medicinal ingredients of yew also contain a class of substances with important pharmacological activities: taxoflavones. Flavonoids (Flavonoids), also known as bioflavonoids (bioflavonoids), are a class of low-molecular plant secondary metabolites, widely distributed in vegetables, fruits and medicinal plants. These compounds have a common core C 6 -C 3 -C 6 At present, hundreds of flavonoids have been isolated from plant materials, and new compounds are constantly being discovered. According to the differe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P9/06A61P9/00A61K36/13A61P9/10A61K127/00
Inventor 王强阮晓张莺莺
Owner 宁波泰康红豆杉生物工程有限公司
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