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Anticancer analgesic preparation and preparation method thereof

A preparation, the technology of cymbidium, which is applied in the field of medicine, can solve the problems of restricting widespread use, causing body, dependence and drug resistance, etc., and achieving the effects of accurate dose, small dose and high bioavailability

Inactive Publication Date: 2010-06-02
TIANJIN ZHONGTIAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Clinically, opioid analgesics are mainly used in the treatment of cancer pain. They can improve people's pain threshold, but there are also many adverse reactions, such as constipation, respiratory depression, lethargy, nausea and vomiting, acute poisoning, especially Develop physical dependence and drug resistance, thus limiting its widespread use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A preparation method of an anti-cancer analgesic preparation, comprising the following steps:

[0022] (1) raw materials are taken by weight percentage: Panax notoginseng 60%; Cicada slough 20%; Viper 20%;

[0023] (2) reflux extracting the raw material with 75% ethanol aqueous solution with a mass percent concentration of 2 times, each time adding ethanol aqueous solution to 8 times the mass of the raw material, extracting for 2 hours each time, merging the extracts, and filtering; When the filtrate is concentrated to a clear paste with a relative density of 1.20 at 73°C, it is spray-dried into a fine powder;

[0024] (3) Mix the fine powder with polyethylene glycol 6000 equivalent to 6 times of the fine powder and stearic acid equivalent to 0.5 times of the fine powder, heat and melt, stir evenly, and drop it into dripping pills, that is, to make a Anticancer analgesic preparations. The drop pill process conditions are shown in Table 1.

Embodiment 2

[0026] A preparation method of an anti-cancer analgesic preparation, comprising the following steps:

[0027] (1) raw materials are taken by weight percentage: Panax notoginseng 70%; Cicada slough 20%; Viper 10%;

[0028] (2) reflux extracting the raw material with 70% ethanol aqueous solution with a mass percentage concentration of 2 times, each time adding ethanol aqueous solution to 6 times the quality of the raw material, extracting for 3 hours each time, merging the extracts, and filtering; When the filtrate is concentrated to a clear paste with a relative density of 1.15 at 75°C, it is spray-dried into a fine powder;

[0029] (3) Mix the fine powder with polyethylene glycol 4000 equivalent to 8 times of the fine powder, and glycerol monostearate equivalent to 0.2 times of the fine powder, heat and melt, stir evenly, and drop into dropping pills, that is, into an anticancer analgesic preparation. The drop pill process conditions are shown in Table 1.

Embodiment 3

[0031] A preparation method of an anti-cancer analgesic preparation, comprising the following steps:

[0032] (1) raw materials are taken by weight percentage: Panax notoginseng 50%; Cicada slough 30%; Viper 20%;

[0033] (2) Adding the raw material with a mass percent concentration of 60% ethanol aqueous solution for reflux extraction 3 times, each time adding the ethanol aqueous solution to 4 times the quality of the raw material, extracting for 3 hours each time, merging the extracts, and filtering; When the filtrate is concentrated to a clear paste with a relative density of 1.05 at 70°C, it is spray-dried into a fine powder;

[0034] (3) Mix the fine powder with sodium stearate 2 times the amount of fine powder, and worm wax 0.7 times the amount of fine powder, heat and melt, stir evenly, and drop it into a dripping pill, which is an anticancer drug. Analgesic preparations. The drop pill process conditions are shown in Table 1.

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PUM

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Abstract

The invention discloses an anticancer analgesic preparation and a preparation method thereof. The anticancer analgesic preparation is prepared from the following raw materials in percentage by weight: 50 to 70 percent of sanchi; 10 to 30 percent of cicada slough; and 10 to 30 percent of long-nosed pit viper. The anticancer analgesic preparation has the advantages of accurate dosage, little weight difference, and high bioavailability, and guarantees the dosage of the patient. The dose is small; the patient takes one bag each time; and the anticancer analgesic preparation is convenient for administration and carrying. The pills of the invention do not contain sugar; and compared with sugar coated tablets, sugary granules and oral liquid, the pills enlarge administration population and are suitable for sugar forbidden population such as diabetics, obesity patients, and the like. The anticancer analgesic preparation and the preparation method thereof have the advantages of simple equipment, convenient operation, little dust in the production process and small environmental pollution.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical preparation for anticancer and pain relief and a preparation method. Background technique [0002] Pain in cancer patients is a common symptom of advanced cancer. Pain often varies from person to person, and the degree of pain is often related to people's psychological activities such as recall of past experiences, analysis of pain causes, understanding of situations, degree of attention, and prediction of consequences, so pain is quite random and variable . [0003] Pain affects the body in various ways, and pain can affect pulse rate. Superficial pain can cause tachycardia. Severe deep pain can slow the pulse rate and occasionally lead to cardiac arrest. Pain can interfere with breathing. If the pain involves the chest wall, the patient will have abdominal breathing, if the abdominal pain can be seen chest breathing, severe pain can make the breathing shall...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K9/20A61P35/00A61P29/00A61P25/04A61K35/64A61K35/58A61K35/583
Inventor 李叔达
Owner TIANJIN ZHONGTIAN PHARMA
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