Method for preparing alpha-lipoic acid liposome

Abstract

The invention discloses a method for preparing an alpha-lipoic acid liposome, which comprises: dissolving soyabean lecithin and cholesterol in an organic solvent and adding the solution into solution of alpha-lipoic acid to form liposome solution, wherein the mass ratio of the soyabean lecithin to the cholesterol to the alpha-lipoic acid is 3.1-3.5:1:0.03-0.06; forming a thin film by water bath treatment, pressure reduction and distillation; and adding an ethylether assistant and forming the homogeneous liposome by hydration and crushing. The alpha-lipoic acid liposome preparation by the method is homogeneous, stable and high in entrapment rate and is favorable for industrial production.

Description

technical field

[0001] The invention relates to the field of preparation of α-lipoic acid, in particular to a preparation method of α-lipoic acid liposome. Background technique

[0002] Since liposomes were discovered by A.D.Bangham in 1965, liposomes have developed rapidly in the fields of biophysics, colloid science, chemistry, and cells. In particular, drug-loaded liposomes have attracted more and more attention because of their good cell affinity, targeting, sustained release and reduced drug toxicity. At present, there are many methods for preparing liposomes, commonly used are thin film method, reverse phase evaporation method, solvent injection method and double emulsion method, etc. These methods are generally called passive drug loading method; pH gradient method, ammonium sulfate gradient method, etc. Generally known as the active drug loading method. However, in the preparation process of some drug-loaded liposomes, problems such as the morphology and particle s...

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