Anti-inflammatory drug (polysaccharide conjugate) as well as preparation and application of drug composition thereof

Abstract

The invention discloses an anti-inflammatory drug (polysaccharide conjugate) as well as preparation and application of a drug composition thereof. The anti-inflammatory drug composition comprises an anti-inflammatory drug (polysaccharide conjugate) and slow-acting antirheumatic drugs. The anti-inflammatory drug (polysaccharide conjugate) has amphipathic characteristics by using alkylene diamines as a connecting arm and introducing hydrophobic non-steroidal anti-inflammatory drugs containing carbonyl on a polysaccharide framework, and is self-assembled to form a nano micelle in water, thereby physically coating the antirheumatic drugs, combining the chemically coupled non-steroidal anti-inflammatory drugs, and achieving the effect of combination treatment on the rheumatoid arthritis. The conjugate and the drug composition have high safety and good treatment effect, and can be used for injection, oral administration or external drug administration.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to an anti-inflammatory drug-polysaccharide conjugate with good anti-inflammatory activity and biodegradability as a drug carrier for combined therapy. The invention also relates to a preparation method of the conjugate and a drug combination thereof application of things. Background technique [0002] Rheumatoid arthritis is an autoimmune disease of unknown etiology. Treatment methods include drug therapy, surgical treatment, and psychotherapy, etc., and drug therapy is generally the main method. Antirheumatic drugs can be divided into four major categories: NSAIDs, disease-modifying antirheumatic drugs, corticosteroids, and botanicals. [0003] Studies have shown that no single drug can both relieve symptoms and improve the condition, nor can it be used alone for a long time. For example, non-steroidal anti-inflammatory drugs such as ibuprofen and indomethacin have good...

AI Technical Summary

Problems solved by technology

Some polysaccharide-drug conjugates are currently in the research stage, but these conjugates are only administered in the form of drug-polysaccharide conjugates, and it is still impossible to achieve the purpose of combined therapy through one formulation, and the drug release behavior is single, which is difficult to achieve. Meeting the Treatment Requirements for Rheumatoid Arthritis

In addition, there are also the following defects: the inherent difficulties in the chemical reaction of the polymer itself make the synthesis conditions relatively harsh and the yield is low; when the condensation cannot be directly carried out through functional groups such as hydroxyl and amino groups, the linking arms used are more complicated, such as amino acids Or peptides; the grafting rate of hydrophobic drugs is low, and the drug loading capacity is not high, which makes it difficult to reach the dosage and affects the therapeutic effect, etc.

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