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Medical composition containing amoxicillin and dicloxacillin sodium

A technology of dicloxacillin sodium and amoxicillin, which is applied in the field of solid pharmaceutical compositions containing amoxicillin and dicloxacillin sodium, and can solve the problems of poor acid resistance, poor patient compliance, and hidden dangers of stability of amoxicillin

Inactive Publication Date: 2010-07-07
BEIJING D VENTUREPHARM TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the acid resistance of amoxicillin is poor, and it is easy to destroy in the stomach. Dicloxacillin sodium has a bitter taste. When it is used for oral granules and buccal tablets, the patient's compliance is poor, and the mixed granulation of the two is also difficult. There is a risk of stability

Method used

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  • Medical composition containing amoxicillin and dicloxacillin sodium
  • Medical composition containing amoxicillin and dicloxacillin sodium
  • Medical composition containing amoxicillin and dicloxacillin sodium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018]

[0019]

[0020] Preparation:

[0021] Weigh the prescribed amount of amoxicillin, add disodium hydrogen phosphate, lactose, microcrystalline cellulose, carboxymethyl starch sodium and mix evenly, add water, granulate, and dry; otherwise weigh the prescribed amount of dicloxacillin sodium, add PEG6000 , melt and clathrate to prepare the clathrate of dicloxacillin sodium, add sucrose, microcrystalline cellulose, sodium carboxymethyl starch, sucralose to the clathrate of dicloxacillin sodium, mix evenly, add water, granulate, dry. Mix the granules of amoxicillin and dicloxacillin sodium evenly, add magnesium stearate, and press into tablets to obtain the product.

Embodiment 2

[0023]

[0024] Preparation:

[0025] Weigh the prescribed amount of amoxicillin, add sodium bicarbonate, lactose, mannitol, low-substituted hydroxypropyl cellulose, and orange powder essence, mix evenly, add the aqueous solution of the color lake, granulate, and dry; Cloxacillin sodium, add hydroxypropyl methylcellulose and spray dry to prepare the inclusion compound of dicloxacillin sodium, add sucrose, mannitol, low-substituted hydroxypropyl cellulose, sucralose to the inclusion compound of dicloxacillin sodium , orange powder essence, mix evenly, add the aqueous solution of color lake, granulate and dry. Mix the granules of amoxicillin and dicloxacillin sodium evenly, put them into an aluminum-plastic composite film bag, and obtain the product.

Embodiment 3

[0027]

[0028] Preparation:

[0029] Weigh the prescribed amount of amoxicillin, add sodium hydroxide, sucrose, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, and orange powder essence, mix evenly, add the aqueous solution of the lake, granulate, and dry; Dicloxacillin sodium, add hydroxypropyl methylcellulose, spray dry to prepare the inclusion compound of dicloxacillin sodium, add sucrose, microcrystalline cellulose, low-substituted hydroxypropyl cellulose to the inclusion compound of dicloxacillin sodium Vegetarian, sucralose, and orange powder essence are mixed evenly, and the aqueous solution of color lake is added, granulated, and dried. Mix the granules of amoxicillin and dicloxacillin sodium evenly, put them into an aluminum-plastic composite film bag, and obtain the product.

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PUM

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Abstract

The invention discloses a medical composition containing amoxicillin and dicloxacillin sodium, wherein, the amoxicillin and the dicloxacillin sodium in the medical composition are dispersed on respective pharmaceutically acceptable carrier. The composition has good stability and broad spectrum antibacterial function.

Description

technical field [0001] The invention relates to a broad-spectrum antibacterial pharmaceutical composition, in particular to a solid pharmaceutical composition containing amoxicillin and dicloxacillin sodium. Background technique [0002] Amoxicillin is a broad-spectrum penicillin antibiotic, but its acid resistance is weak. Dicloxacillin sodium is isoxazole penicillin, which has strong acid resistance and is not easily destroyed by penicillinase. The combination of the two has a synergistic effect, stronger antibacterial effect, and a wider antibacterial spectrum. It is used to treat respiratory tract infections, digestive tract infections, genitourinary system infections, ear, nose and throat, oral infections, bone and joint infections, skin and soft tissue infections. . [0003] CN 101015529A discloses a sustained-release preparation of amoxicillin and dicloxacillin. CN 1813722A discloses a composition of amoxicillin and dicloxacillin sodium. Whether they are sustained...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/43A61K31/431A61P31/04
Inventor 袁筝
Owner BEIJING D VENTUREPHARM TECH DEV