Use of probiotics and fibers for diarrhoea

A technology of diarrhea and Lactobacillus rhamnosus, applied in the field of infant nutrition, can solve problems such as not always effective and side effects

Active Publication Date: 2010-07-07
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this doesn't always work and often has serious side effects

Method used

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  • Use of probiotics and fibers for diarrhoea
  • Use of probiotics and fibers for diarrhoea
  • Use of probiotics and fibers for diarrhoea

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1: use the mixture of Lactobacillus rhamnosus, inulin and soybean polysaccharide and trace Nutrient supplementation to shorten the duration of acute infantile diarrhea

[0052] method:

[0053] A randomized, double-blind clinical trial was conducted to evaluate the efficacy of an infant formula containing Lactobacillus rhamnosus (a probiotic) and dietary fiber (inulin and soybean polysaccharides) in the treatment of 58 children aged 3-12 months with moderately dehydrated acute diarrhea. Effects in well-nourished Indonesian male infants. After adequate oral rehydration, patients were randomly assigned to receive: low-lactose infant formula, including Lactobacillus rhamnosus (5 × 10 8 / 100ml) and dietary fiber (0.15g inulin / 100ml and 0.25g soybean polysaccharide / 100ml) and higher concentrations of several specific micronutrients (1.1mg iron / 100ml, 0.9mg zinc / 100ml, 0.05mg Copper / 100ml, 7μg manganese / 100ml, 1.0μg selenium / 100ml, 1.9mg vitamin D3 / 100ml and ...

Embodiment 2

[0057] Example 2: Synergistic effect of soybean PS, inulin and Lactobacillus rhamnosus

[0058] Material:

[0059] An in vitro semi-dynamic batch fermentation system was used using children's feces.

[0060] Fibrim (Solae) was used as soybean PS source. RaftilinST (Orafti) was used as source of inulin and LGG (Valio) as source of Lactobacillus rhamnosus.

[0061] Fresh feces were obtained from 2-year-old healthy children.

[0062] The experimental medium is McBain&MacFarlane medium (buffered peptone water 3.0g / l, yeast extract 2.5g / l, tryptone 3.0g / l, L-cysteine-HCl 0.4g / l, bile salt 0.05g / l, K 2 HPO 4 ·3H 2 O 2.6g / l, NaHCO 3 0.2g / l, NaCl 4.5g / l, MgSO 4 ·7H 2 O 0.5g / l, CaCl 2 0.228g / l, FeSO 4 0.005g / l).

[0063] method:

[0064] Fresh fecal material was mixed with McBain & MacFarlane medium representative of the intestinal environment in a weight ratio of 1:5.

[0065] At t=0, 6 ml of feces suspension was mixed with fiber and domain L GG, transferred to a dia...

Embodiment 3

[0075] Example 3: Infant Nutrition

[0076] An infant nutrition product comprising:

[0077] - Vegetable fat fraction, providing 27% of total calories, polyunsaturated fatty acids 40% of total fatty acids, LA / ALA weight ratio 5.5.

[0078] - Milk protein fraction, providing 12% of total calories, consisting of 20 wt.% whey protein and 80 wt.% casein, and

[0079] - A digestible carbohydrate component, providing 61% of total calories, comprising more than 80 wt.% of maltodextrin and starch.

[0080] - Lactobacillus rhamnosus: 5 x 10 8 cfu / 100ml.

[0081] - Inulin: 0.15g / 100ml

[0082] -Soy polysaccharide: 0.25 / 100ml

[0083] The label on the package of the infant nutritional product states that the nutritional product is to be used in case of diarrhea.

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Abstract

The present invention relates to nutritional compositions comprising Lactobacillus rhamnosus, inulin and soy polysaccharides for the treatment of diarrhoea.

Description

technical field [0001] The present invention belongs to the field of infant nutrition comprising probiotics and fibres, for the prevention and / or treatment of diarrhoea. Background technique [0002] Diarrhea is a serious public health problem and a major cause of malnutrition, responsible for a quarter of all deaths among children under 5 years of age in developing countries, especially infants. Diarrhea causes more than 1 billion episodes of disease each year, an average of 3 episodes per child globally, and nearly 5 million deaths worldwide. [0003] For acute diarrhea, especially in infants, the current recommendation is to replace fluid and electrolyte losses while providing nutritional support. But this treatment did not shorten the duration of the diarrhea. Options that can shorten the duration of diarrhea include antibiotics, anti-motility, and secretion-suppressing drugs. But this doesn't always work and often has serious side effects. The general consensus is t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/30A23L1/308A61K31/7024A61K31/715A61K35/74A61K35/747
CPCA61K35/747A61K31/7024A23L1/308A23L1/3014A23L1/0528A61K31/715A23L1/3081A23L1/3002A23L29/244A23L33/105A23L33/135A23L33/21A23L33/22A61P1/12A61K2300/00
Inventor J·宾德尔斯A·C·哥德哈特
Owner NV NUTRICIA
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