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Use of melanin biosynthesis inhibitors from korean ginseng and the cosmetic composition containing thereof for skin whitening

Ginsenoside F1, prepared by reacting ginseng extract with acid, alkali or enzyme, solves the problem of poor melanin inhibition effect in existing cosmetics, achieves effective skin whitening and product stability, and significantly inhibits UV light-induced of melanin pigmentation.

Inactive Publication Date: 2010-09-01
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of these substances is limited due to insufficient whitening effect and other problems such as skin safety problems, formulation and stability problems caused by adding the above substances to cosmetics

Method used

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Examples

Experimental program
Comparison scheme
Effect test

reference example 1

[0023] Reference Example 1: Preparation of Ginseng Extract

[0024] 2 kg of ginseng was added to 4 L of methanol aqueous solution, extracted three times under reflux, and then cultured at 15° C. for one day. Next, the extracted plant was separated into a residue and a filtrate by filtration with a filter cloth and centrifugation, and the filtrate was concentrated under reduced pressure. The concentrate was suspended in water, then extracted 5 times with 1 L of ethanol to remove the pigment therein, and the aqueous layer was extracted 3 times with 500 mL of 1-butanol. The entire obtained 1-butanol layer was concentrated under reduced pressure to obtain a 1-butanol extract, which was then dissolved in a small amount of methanol and added to a large amount of ethyl acetate middle. The resulting precipitate was dried to obtain 100 g of ginseng extract.

Embodiment 1

[0025] Example 1: Preparation of Ginsenoside F1 by Acid Hydrolysis

[0026] The ginseng extract that 10g reference example 1 obtains is added in the methanol solution (volume / volume) of the 1N HCl-50% of 20 times volume (volume / weight), and by at 80 ℃, reflux in water bath 8 hours for hydrolysis. Then, the reaction solution was concentrated under reduced pressure to remove the solvent, and the residue was added to 200 mL of ethanol and stirred 3 times. The precipitated salt was then removed by filtration, and the filtrate was concentrated under reduced pressure, whereby a crude product was obtained. The crude product was purified by silica gel column chromatography (chloroform:methanol=8:1-4:1), thereby obtaining 1.25 g of ginsenoside F1.

Embodiment 2

[0027] Example 2: Preparation of Ginsenoside F1 by Alkaline Hydrolysis

[0028] 10 g of the ginseng extract obtained in Reference Example 1 was dissolved in 500 mL of dry pyridine, and 10 g of sodium methoxide powder was added thereto. Then, hydrolysis was performed by heating under reflux in a water bath for 8 hours, and the reaction solution was concentrated under reduced pressure to remove the solvent. The residue was added to 200 mL of ethanol and stirred 3 times. Precipitated salts were removed by filtration. The filtrate was concentrated under reduced pressure, whereby a crude product was obtained. The crude product was purified by silica gel column chromatography (chloroform:methanol=8:1-4:1), thereby obtaining 0.85 g of ginsenoside F1.

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Abstract

Disclosed herein is a whitening cosmetic composition containing plant-derived ginsenoside Fl (20-O-ss-D- glucopyranosyl-20 (S) -protopanaxatriol) as an active ingredient. More specifically, the ginsenoside Fl is obtained from particularly a ginseng extract using an acid, a base, an enzyme or microorganism, and a whitening cosmetic composition containing the ginsenoside Fl has an excellent effect of inhibiting melanin biosynthesis, and thus provides an excellent skin whitening effect.

Description

technical field [0001] The present invention relates to the use of ginsenoside F1 obtained from ginseng extract using acid, alkali, enzyme or microorganism producing the enzyme, and a cosmetic composition for skin whitening containing the ginsenoside F1. Background technique [0002] A person's skin color is determined by a variety of factors, such as the activity of melanin-producing melanocytes in the body, the distribution of blood vessels, the thickness of the skin, and the presence or absence of pigments (e.g., carotenoids, bilirubin, etc.), among others. factors, etc.) play an important role. The most important factor among them is melanin produced by the activity of various enzymes (for example, tyrosinase) in human melanocytes. The formation of melanin is influenced by genetic factors, hormone secretion, physiological factors related to stress, and environmental factors such as ultraviolet (UV) light exposure. [0003] Melanin produced in melanocytes on human skin ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/60A61Q19/02A61P17/18
CPCA61K8/97A61Q19/02A61K8/60A61K8/9728A61K8/9789A61P17/18
Owner AMOREPACIFIC CORP
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