Camellia nitidissima tea polyphenols slow release microsphere particle and production method thereof

A technology for slow-release microspheres and camellia tea, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, plant raw materials, etc., can solve the problems of structural damage, oxidation, polymerization, condensation, poor fat solubility, etc., to reduce damage. , Improve the effect of active maintenance and large loss of active ingredients

Inactive Publication Date: 2012-07-04
GUANGXI FUXIN SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] Many plant antioxidant components, such as tea polyphenol powder, are prone to oxidation, polymerization, condensation and other reactions under conditions such as humidity, sunlight, and high temperature; tea polyphenols will undergo self-oxidation when they are used for antioxidant protection; fat solubility is poor; When digested in the stomach and intestines, the structure will be destroyed and there will be problems such as astringent taste, which limits the application of tea polyphenols

Method used

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  • Camellia nitidissima tea polyphenols slow release microsphere particle and production method thereof
  • Camellia nitidissima tea polyphenols slow release microsphere particle and production method thereof
  • Camellia nitidissima tea polyphenols slow release microsphere particle and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Remove impurities, rotten and diseased yellow leaves from the Jinhua tea leaves that have been picked for no more than 24 hours, clean them and cut them into small leaflets with a width of 1 to 2 cm, add 5 times the water and 0.05% of the weight of the feed liquid compound fruit pulp enzyme (Qingdao The KDN-F01 pulp enzyme produced by Kangdien Biotechnology Co., Ltd., the main component: mainly acid pectinase, containing hemicellulase such as xylanase and β-glucanase.), stirring and heating to 40 ℃, after keeping the temperature for 2 hours, quickly heat to 100 ℃ to inactivate the enzyme for 10 minutes. Then add pure water 5 times the weight of fresh leaves. When the temperature of the feed liquid reaches about 60°C, use an ultrasonic traditional Chinese medicine extraction unit (TCD-1000) to carry out vibration extraction. The extraction time is 65 minutes and the frequency is 25kHz. After the first ultrasonic oscillation is finished, filter, and then add 10 times of p...

Embodiment 2

[0048] Remove impurities, rotten and diseased yellow leaves from the golden camellia tea leaves that have been picked for no more than 24 hours, clean them, cut them into 1-2 cm wide leaflets, add 5 times the water to make a pulp. Heat the slurry obtained by beating to 40°C, add 0.05% pectinase (the NCB-PE200 compound pulp enzyme produced by Hunan Youtel Biochemical Co., Ltd., mainly composed of pectinase and cellulase) , and contains a certain amount of hemicellulase and β-glucanase.), after stirring at constant temperature for 2 hours, quickly heat to 100°C to inactivate the enzyme for 10 minutes. Then add pure water 5 times the weight of fresh leaves. When the temperature of the feed liquid reaches about 65°C, use an ultrasonic traditional Chinese medicine extraction unit (TCD-1000) to carry out vibration extraction. The extraction time is 60 minutes and the frequency is 50kHz. Filter after the first ultrasonic vibration leaching is finished, and then add 10 times of pure w...

Embodiment 3

[0050]Remove impurities, rotten and diseased yellow leaves from fresh golden camellia leaves that have been picked for no more than 24 hours, clean them and cut them into 1-2 cm wide leaflets, add 5 times the amount of water and 0.05% pectinase (Qingdao KDN-FO1 pulp enzyme produced by Kangdien Biotechnology Co., Ltd.). Stir and heat to 40°C, keep the temperature for 2 hours, then rapidly heat to 100°C to inactivate the enzyme for 10 minutes. Then add pure water 5 times the weight of fresh leaves. When the temperature of the feed liquid reaches about 70°C, use an ultrasonic traditional Chinese medicine extraction unit (TCD-1000) to carry out vibration extraction. The extraction time is 70 minutes and the frequency is 70kHz. Filter after the first ultrasonic vibration leaching is finished, and then add 10 times of pure water to the residue to carry out the second ultrasonic vibration leaching (leaching conditions are the same as the first time). Filter the extract through a 120...

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Abstract

The invention relates to a Camellia nitidissima tea polyphenols slow release microsphere particle made of Camellia nitidissima, wherein the main ingredients comprise Camellia nitidissima tea polyphenols extract, hydroxypropyl methyl cellulose phthalate and dodecyl sodium sulfate; the production method comprises the following steps: cleaning and cutting up the fresh blades of Camellia nitidissima,ultrasonic digestion, separating and concentrating sodium filter membrane, purifying macroporous absorption resin and concentrating at low temperature in vacuum so as to obtain Camellia nitidissima tea polyphenols; adding the Camellia nitidissima tea polyphenols extract to the ethanol aqueous solution of hydroxypropyl methyl cellulose phthalate according to the mass ratio of Camellia nitidissima tea polyphenols extract to hydroxypropyl methyl cellulose phthalate of 2: 1, and adding dodecyl sodium sulfate which is 1 / 16 of the mass of Camellia nitidissima tea polyphenols extract as the emulsifying agent and mixing uniformly, spraying and drying so as to obtain the Camellia nitidissima tea polyphenols slow release microsphere product.

Description

technical field [0001] The invention belongs to health care products made from plant extracts, in particular to slow-release microsphere particles made from the extracts of plant chrysanthemum tea leaves and a production method thereof. Background technique [0002] Camellia chuyxanth (Hu) Tuyanma is a plant of the family Theaceae, Camellia genus, Camellia group, and Camellia family. It was first discovered in Guangxi, my country in the early 1960s. It is a rare plant resource in the world and is known as "" The "Queen of the Tea Clan" and the "Giant Panda" in the Plant Kingdom like warm and humid climates, and are often distributed in shady slopes with loose soil and good drainage. within the zone. Golden camellia tea with golden petals and jade stamens, waxy golden, graceful, glamorous, noble and elegant, is a natural Chinese herbal medicine with extremely high medicinal value. The flowers are used for blood in the stool and irregular menstruation. In recent years, a numb...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/38A61K36/82A61K9/16A61P39/06A61K127/00
Inventor 宁恩创刘志新杨继住秦小明
Owner GUANGXI FUXIN SCI & TECH
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