Compound combined formulation for preventing and treating osteoarthrosis and preparation method thereof

A bone and joint pain and compound technology, which is applied in the field of glucosamine medicine and health products, can solve the problems of single efficacy and low absorption utilization rate, and achieve the effect of fast dissolution, high absorption utilization rate, and rapid onset of effect

Active Publication Date: 2010-09-15
JIANGSU ALAND NOURISHMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a compound combination preparation for preventing and treating bone and joint pain and its preparation method, which solves the problems of single product efficacy and low absorption and util

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Glucosamine 700g

[0026] Microcrystalline Cellulose 121g

[0027] Sodium carboxymethyl starch 45g

[0028] Polyvinylpyrrolidone 35g

[0029] Sodium Carboxymethyl Cellulose 1g

[0030] Tartaric acid 0.28g

[0031] Magnesium Stearate 12g

[0032] Appropriate amount of water

[0033] Titanium dioxide 32g

[0034] Prepare as follows:

[0035] 1) Prepare a 10% aqueous solution of polyvinylpyrrolidone, fully dissolve until clear and transparent;

[0036] 2) Pulverize the glucosamine and pass through a 120-mesh sieve;

[0037] 3) Put glucosamine, tartaric acid and sodium carboxymethylcellulose into a wet granulator and stir for 5 minutes, and mix well;

[0038]4) Evenly and slowly add the solution of the binder prepared in step 1, add liquid while stirring and granulate, after granulating, strictly control the inlet air temperature, dry, and pass through a 20-mesh sieve;

[0039] 5) Add microcrystalline cellulose, sodium carboxymethyl starch, and magnesium stearate ...

Embodiment 2

[0042] Glucosamine 700g

[0043] Chondroitin Sulfate 350g

[0044] Collagen 150g

[0045] Microcrystalline Cellulose 121g

[0046] Sodium carboxymethyl starch 45g

[0047] Polyvinylpyrrolidone 35g

[0048] Sodium Carboxymethyl Cellulose 1g

[0049] Tartaric acid 0.28g

[0050] Magnesium Stearate 12g

[0051] Appropriate amount of water

[0052] Polyethylene glycol 32g

[0053] Prepare as follows:

[0054] 1) Prepare a 10% aqueous solution of polyvinylpyrrolidone, fully dissolve until clear and transparent;

[0055] 2) Pulverize the glucosamine and pass through a 120-mesh sieve;

[0056] 3) Put glucosamine, tartaric acid and sodium carboxymethylcellulose into a wet granulator and stir for 5 minutes, and mix well;

[0057] 4) Evenly and slowly add the solution of the binder prepared in step 1, add liquid while stirring and granulate, after granulating, strictly control the inlet air temperature, dry, and pass through a 20-mesh sieve;

[0058] 5) Add chondroitin sulfa...

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PUM

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Abstract

The invention discloses a compound combined formulation for preventing and treating osteoarthrosis and a preparation method thereof. The compound and composite formulation comprises an active component and auxiliary materials, wherein the active component is glucosamine or a combination of the glucosamine and more than one or two of other active components, i.e. chondroitin sulfuric acid, dimethyl sulfone and collagen, and the glucosamine is glucosamine sulfate or hydrochloride or phosphate or a mixture of the glucosamine sulfate, the hydrochloride and the phosphate; and the auxiliary materials include an excipient, a disintegrating agent, a lubricating agent, an adhesion agent, a stabilizing agent and a wetting agent. The invention has good treating and preventing effects on arthritis and articulate movement damage; a prepared tablet has good disintegrating property, fast dissolution and quick results and achieves the optimal proportion of the using amount of raw materials and various auxiliary materials; and in addition, the product has enhanced stability and high absorption utility ratio.

Description

technical field [0001] The invention belongs to the technical field of glucosamine medicine and health products, and in particular relates to a compound combination preparation for preventing and treating bone and joint pain and a preparation method thereof. Background technique [0002] Osteoarthritis is a common chronic arthritis, and people have been looking for and exploring drugs for the development of osteoarthritis for many years. For a long time, people have used aspirin, non-steroidal analgesics, etc. to help patients relieve pain. These medicines are used for a long time, and some effects gradually decrease, and some produce side effects such as bloating and stomach pain. Arthritis is mainly the degeneration of articular cartilage and secondary hyperosteogeny. Because the mucous membrane at the joint joint is composed of sulfur-containing protein and glucosamine. Sulfur-containing proteins such as collagen and glucosamine can promote the production of collagen, ...

Claims

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Application Information

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IPC IPC(8): A61K31/7008A61K31/737A61K38/39A61P19/02A61P29/00A61K31/10
Inventor 王乔飞卢鹏飞张涛张国栋边立峰夏旭东
Owner JIANGSU ALAND NOURISHMENT
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