Compound cefaclor suspension and preparation method thereof

The technology of cefaclor and suspension, which is applied in the field of pharmaceutical preparations, can solve the problems of poor solubility, slow onset of drug effect and the like, and achieve the effects of stable drug properties, fast onset of effect and easy portability

Inactive Publication Date: 2010-12-15
UNIV OF SHANGHAI FOR SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the problem that the above-mentioned cefaclor and bromhexine hydrochloride have poor solubility in water, and the dissolution and absorption of the medici...

Method used

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  • Compound cefaclor suspension and preparation method thereof
  • Compound cefaclor suspension and preparation method thereof
  • Compound cefaclor suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Compound cefaclor dry suspension, calculated in 1000 bags, its prescription composition:

[0046]

[0047] Taking the preparation of 1000 bags as an example, the preparation method of the above-mentioned compound cefaclor dry suspension is as follows:

[0048] Weigh the prescription amount of sodium saccharin and sunset yellow, add water and stir to dissolve, then add an appropriate amount of 95% ethanol, stir evenly for later use; pass sodium carboxymethyl cellulose and sucrose through an 80-mesh sieve for later use; mix sodium carboxymethyl cellulose and sucrose After mixing, add the above-mentioned ethanol-water solution containing sodium saccharin and sunset yellow to make a soft material, pass through a 30-mesh sieve to granulate, dry at 60°C, and pass the dry granules through a 30-mesh granule; mix the granules with cefaclor and bromine hydrochloride The same amount of Jixin is added and mixed, and finally orange essence is added, mixed evenly, and then packed ...

Embodiment 2

[0056] Compound cefaclor dry suspension, calculated in 1000 bags, its prescription composition:

[0057]

[0058] Weigh the prescription amount of sodium saccharin and sunset yellow, add water and stir to dissolve, then add an appropriate amount of 95% ethanol, stir evenly for later use; pass sodium carboxymethyl cellulose and sucrose through an 80-mesh sieve for later use; mix sodium carboxymethyl cellulose and sucrose After mixing, add the above-mentioned ethanol-water solution containing sodium saccharin and sunset yellow to make a soft material, pass through a 30-mesh sieve to granulate, dry at 60°C, and pass the dry granules through a 30-mesh granule; mix the granules with cefaclor and bromine hydrochloride Add the same amount of Jixin and mix it evenly, and finally add orange essence and micro-powdered silica gel, mix it evenly, and pack it separately (1g / bag).

Embodiment 3

[0060] Mix cefaclor (1 original drug), bromhexine hydrochloride (2 original drug) and related excipients in a certain proportion and then granulate them. The prepared granules are subjected to strong light (4500Lx), high temperature (40°C) Humidity (RH75%) influencing factors investigation, the results are shown in Table 4. It can be seen from Table 4 that the investigation results of the influencing factors of the original drug and various excipients show that its stability is good.

[0061]

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PUM

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Abstract

The invention discloses a compound cefaclor suspension and a preparation method thereof, belonging to the field of pharmaceutical preparations. The compound cefaclor suspension comprises the following components in percentage by weight: 4-50 percent of cefaclor, 0.14-1.75 percent of bromhexine hydrochloride, 0.5-6 percent of macromolecule suspending agent, 0.1-1.8 percent of sweetener, 38.45-95.256 percent of cane sugar, 0.003-1 percent of sunset yellow and 0.001-1 percent of flavoring orange essence. The preparation method comprises the following steps of: after uniformly mixing the macromolecule suspending agent sodium carboxymethylcellulose with the cane sugar, adding an ethanol-water solution containing the sunset yellow and the sweetener saccharin sodium; and after preparing a soft material, granulating and drying, uniformly mixing with the cefaclor, the bromhexine hydrochloride and the flavoring orange essence to obtain the compound cefaclor suspension. The compound cefaclor suspension can be used for treating respiratory tract mild-to-severe infection caused by sensitive bacteria, tonsillitis, chronic bronchitis acute exacerbation, pneumonia, nasosinusitis, and the like.

Description

technical field [0001] The invention relates to a compound cefaclor dry suspension and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] Cephalosporin antibiotics are a class of broad-spectrum semi-synthetic antibiotics, which have the advantages of strong antibacterial effect, resistance to penicillinase, low toxicity, and less allergic reactions than penicillin. At present, cephalosporins account for a large proportion of the world's anti-infective drug market, and their sales currently account for about 40% of the sales of anti-infective drugs. [0003] Cefaclor is a second-generation cephalosporin that inhibits bacterial cell wall synthesis. Broad antibacterial spectrum, against Staphylococcus aureus, hemolytic streptococcus, Streptococcus pneumoniae, Haemophilus influenzae, Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Neisseria gonorrhoeae, Propionibacterium acnes, Bacteroides , Peptococcu...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/545A61P31/04A61P11/00A61P11/04A61P11/02A61K31/137
Inventor 刘哲鹏潘风施与群
Owner UNIV OF SHANGHAI FOR SCI & TECH
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