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Non-insulin-dependent diabetes mellitus-resisting liriope spicata fructosan and preparation method and application thereof

A technology of fructan and Ophiopogon japonicus, applied in the field of traditional Chinese medicine for the treatment of type II diabetes, can solve problems such as adverse reactions, inability to effectively control chronic complications, and secondary failure

Active Publication Date: 2011-01-12
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the chemical drugs currently used clinically to treat diabetes have serious adverse reactions, and long-term use needs to be increased and there is a possibility of secondary failure, especially the chronic complications cannot be effectively controlled

Method used

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  • Non-insulin-dependent diabetes mellitus-resisting liriope spicata fructosan and preparation method and application thereof
  • Non-insulin-dependent diabetes mellitus-resisting liriope spicata fructosan and preparation method and application thereof
  • Non-insulin-dependent diabetes mellitus-resisting liriope spicata fructosan and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0124] The preparation of Hubei Ophiopogon japonicus fructan of the present invention:

[0125] Take Hubei Ophiopogon japonicus tuber 5kg, crush it into raw medicinal material powder, add water to decoct 3 times, add 20 liters of water for the first time, add 20 liters of water for the second time, add 10 liters of water for the third time, boil for 30 minutes each time, and combine the decoction The water decoction was adjusted to pH 6 with phosphate buffer solution, 25g of papain with an activity of 12u / mg was added, enzymolyzed in a water bath at 45°C for 2 hours, then immediately boiled for 5 minutes, left to stand at 4°C for more than 12 hours, and pumped Filter out the precipitate; put the filtrate into a dialysis bag with a molecular weight of 1000, dialyze with tap water for 1 day, then dialyze with distilled water for 1 day, concentrate the polysaccharide solution in the bag to 1.5g / mL, add absolute ethanol until the volume fraction of ethanol is 80%, 4 Stand still at...

Embodiment 2

[0127] Preparation of Hubei Ophiopogon japonicus fructan capsules: 10 g of microcrystalline cellulose was added to 240 g of Hubei Ophiopogon japonicus fructan powder, mixed evenly, sieved, and dried to obtain the medicinal raw material of the drug capsule. The medicinal raw materials were filled into 727 capsules, and each capsule containing 0.33g of Hubei Ophiopogon japonicus fructan was prepared, which was equivalent to each capsule containing 2.68g of Hubei Ophiopogon japonicus medicinal material. It is recommended that adults take Hubei Ophiopogon japonicus fructan capsules once a day in the morning and before dinner, 1 capsule each time, for more than 4 weeks.

Embodiment 3

[0129] Preparation of Hubei Ophiopogon japonicus fructan tablet: Add 10 g of microcrystalline cellulose to 240 g of Hubei Ophiopogon japonicus fructan powder, mix evenly, sieve, and dry to obtain the medicinal raw material of the drug tablet. The medicinal raw materials were dry-processed into granules and compressed into tablets to obtain 1454 pharmaceutical tablets of Ophiopogon japonicus fructan, each tablet containing 0.165g of Ophiopogon japonicus fructan, which was equivalent to 1.34g of the raw medicinal material of Ophiopogon japonicus hubei in each capsule. It is recommended that adults take Hubei Ophiopogon japonicus fructan tablets twice a day, once in the morning and before dinner, 2 tablets each time, for more than 4 weeks.

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Abstract

The invention provides liriope spicata fructosan consisting of nineteen beta-D-fructose and one alpha-D-glucose. The liriope spicata fructosan comprises a main chain consisting of fructose residues bonded at positions 1 and 2 and six repeating units, wherein each unit comprises one disubstituted fructose residue bonded at positions 1 and 2, one trisubstituted fructose residue bonded at positions 1, 2 and 6 and one monosubstituted fructose residue bonded at position 2; and hydroxyl at position 2 at one terminal of the main chain of a polysaccharide is bonded with hydroxyl at position 1 of the alpha-D-glucose to form a glycoside, and hydroxyl at position 1 at the other terminal of the main chain of the polysaccharide is bonded with hydroxyl at position 2 of one beta-D-fructose to form a glycoside. The liriope spicata fructosan has the advantages of capacity of obviously reducing the blood glucose of mice suffering from non-insulin-dependent diabetes mellitus and the insulin resistance, reducing the total cholesterol and triglyceride in blood, increasing the ratio of high-density lipoprotein to low-density lipoprotein better and more effectively preventing and treating arteriosclerosis and thrombosis, wherein the strength of the insulin resistance and that of rosiglitazone do not have any statistical difference.

Description

technical field [0001] The invention relates to traditional Chinese medicine technology, in particular to a traditional Chinese medicine for treating type II diabetes. Background technique [0002] Diabetes mellitus (DM) is a chronic systemic frequently-occurring disease related to genetic factors and various environmental factors. It is a syndrome of sugar, fat and protein metabolism disorders caused by insufficient insulin secretion or utilization. Diabetes disease" category. The prevalence of diabetes in my country is increasing year by year, especially in type 2 diabetes (non-insulin-dependent diabetes mellitus, NIDDM), but there is no ideal drug for treatment at home and abroad. Most of the chemical drugs currently used clinically to treat diabetes have serious adverse reactions. Long-term use needs to be increased and there is a possibility of secondary failure, especially the chronic complications cannot be effectively controlled. Traditional Chinese medicine has th...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/733A61K9/20A61K9/48A61P3/10
Inventor 陈家春陈祥洪白雪文莉
Owner HUAZHONG UNIV OF SCI & TECH
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