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Preparation method of surface dendritic macromolecule modified superparamagnetism ferroferric oxide nano particle

A triiron tetroxide and superparamagnetic technology, which is applied in the manufacture of nanostructures, ferrous oxides, iron oxide/iron hydroxide, etc. Large particle size, poor superparamagnetic properties, etc., to achieve the effects of good compatibility and stability, high surface polymer content, good solubility and stability

Inactive Publication Date: 2012-07-04
EAST CHINA NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although there is a report on the preparation method of dendritic polymer polyamide-amine (PAMAM) modified magnetic iron ferric oxide nanoparticles (CN1913055A), the selected magnetic iron ferric oxide nanoparticles have a large particle size, and their super The paramagnetism is poor, the adsorbed dendrimer is not uniform, and it is only soluble in water, which limits its practical application

Method used

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  • Preparation method of surface dendritic macromolecule modified superparamagnetism ferroferric oxide nano particle
  • Preparation method of surface dendritic macromolecule modified superparamagnetism ferroferric oxide nano particle
  • Preparation method of surface dendritic macromolecule modified superparamagnetism ferroferric oxide nano particle

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Synthesis of superparamagnetic Fe by pyrolysis 3 o 4 The nanoparticle material is then reacted with carboxyl-bearing polyamide-amine (PAMAM) dendrimers for surface modification to generate superparamagnetic Fe with surface-modified PAMAM dendrimers 3 o 4 Nanoparticles, the size of which is 6-10nm.

[0033] Add 5.65g iron acetylacetonate (Fe(acac) 3 ), 13.6g oleic acid, 12.8g oleylamine and 120ml diphenyl ether, after mixing evenly, in N 2 Under protection, slowly heat from room temperature to 100°C, stir and react for 0.5h, then raise the temperature to 200°C for 2h, then heat to reflux temperature (about 256°C), remove heat source after reflux for 1h, and cool to room temperature naturally. After ethanol washing, strong magnet separation, redissolution, centrifugation and collection, and vacuum drying at 80°C, black solid superparamagnetic Fe was obtained. 3 o 4 Nanoparticles.

[0034] Add 0.5g Fe to a three-necked flask equipped with mechanical stirring and ref...

Embodiment 2

[0040] Synthesis of superparamagnetic Fe by pyrolysis 3 o 4 The nanoparticle material is then reacted with carboxyl-bearing polyester dendrimers for surface modification to generate superparamagnetic Fe with surface-modified dendrimers 3 o 4 Nanoparticles, the size of which is 6-10nm.

[0041] Add the superparamagnetic Fe prepared by 0.5g of above-mentioned example one step (a) in the three-neck flask that mechanical stirring, reflux condenser are housed 3 o 4 Nanoparticles, 10ml DMF, 20ml of butanone solution of 1.0g polyester dendrimer (m=2) and 20ml o-dichlorobenzene, after stirring and mixing evenly, in N 2 Under protection, the temperature was raised and kept at 70°C for 48h. Stop the reaction, naturally cool to room temperature, and separate with a magnet. The obtained black solid is dissolved in butanone and then centrifuged. After repeated washing and centrifugation for 2-3 times, vacuum-dry to obtain a superparamagnetic surface-modified polyester dendritic polyme...

Embodiment 3

[0044] Example 3 Preliminary Determination of Drug Loading

[0045] Weigh the superparamagnetic Fe of the surface-modified PAMAM dendrimer synthesized in Example 1 of 10 mg 3 o 4 Put the nanoparticles and 2.5 mg doxorubicin (Dox) into the reaction tube, add 3-4ml methanol and 60 microliters of triethylamine, stir at room temperature in the dark for 24 hours, stop stirring, and separate the upper layer with a magnet Collect, superparamagnetic Fe of the surface-modified PAMAM dendrimer synthesized in Example 1 is detected by ultraviolet-visible 3 o 4 The drug loading of nanoparticles can reach 23%.

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Abstract

The invention provides a preparation method of a surface dendritic macromolecule modified superparamagnetism ferroferric oxide nano particle, which is characterized by comprising the following steps of: synthesizing a superparamagnetism ferroferric oxide nano particle by adopting a pyrolytic process; then reacting the superparamagnetism ferroferric oxide nano particle with a dendritic macromolecule with hydroxyl for surface modification to form the surface dendritic macromolecule modified superparamagnetism ferroferric oxide nano particle, wherein the particle diameter of the nano particle is6-10 nm. The preparation method has the advantages of simplicity, easy enforcement and strong controllability; and the product prepared in the method has favorable dissolubility and stability in an organic polar solvent and has huge application prospect in nuclear magnetic resonance contrast agents, drug magnetic targeting transportation, magnetic thermal therapy, magnetic separation and the like.

Description

technical field [0001] The invention belongs to the technical field of modification of inorganic nanometer materials, and in particular relates to a preparation method of superparamagnetic ferric iron tetroxide nanoparticles whose surface is modified with dendritic polymers. Background technique [0002] Due to the characteristics of size effect, surface effect, quantum effect, and macroscopic quantum tunneling effect, nanomaterials show remarkable characteristics different from general macroscopic materials in terms of optics, mechanics, electricity, and magnetism, and have developed rapidly in recent years. [0003] Ferric oxide (Fe 3 o 4 ) Nanoparticles are a new type of nanomaterial developed in recent years. Due to their special physical and chemical properties, they have broad application prospects in nanotechnology and biological fields, such as magnetic memory materials, nuclear magnetic resonance contrast agents, and magnetically targeted drug delivery. , Magnetic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01G49/08B82B3/00
Inventor 贺小华吴晓萌高春燕钟亮
Owner EAST CHINA NORMAL UNIV