Polydopamine microcapsules and preparation method thereof

A polydopamine microcapsule and dopamine technology, which is applied in the preparation of microspheres, microcapsule preparations, etc., can solve the problems of poor process controllability, adhesion of microcapsules, poor controllability, etc., and achieves simple operation, good stability, and particle size. controllable effect

Inactive Publication Date: 2011-02-09
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is characterized by simple equipment, wide sources of polymer materials, and is suitable for microencapsulation of various drugs. The disadvantage is that microcapsules adhere and aggregate, and the process controllability is poor.
(3) Physical and mechanical methods, mainly through the physical changes of microcapsule wall materials, combined with certain mechanical processing methods for microcapsule preparation, poor controllability

Method used

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  • Polydopamine microcapsules and preparation method thereof
  • Polydopamine microcapsules and preparation method thereof
  • Polydopamine microcapsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Dissolve 30 mg of sodium polystyrene sulfonate (PSS) in 15 mL of filtered calcium chloride solution (with a concentration of 0.2M), and add 15 mL of filtered 0.2M sodium carbonate solution to the solution at a rotation speed of 1000 rpm React in the electromagnetic stirrer for 15 seconds, turn off the electromagnetic stirring and let it stand for 15 minutes, then turn on the electromagnetic stirring, stir the reaction solution evenly, and add 5 mL to the centrifuge tube. Take a total of 4 tubes. Centrifuge the 4 tubes of suspension in a centrifuge with a rotating speed of 3000 rpm for 3 minutes and then wash with deionized water, and repeat the centrifugation-washing operation twice.

[0024] Prepare 0.01M Tris-HCl buffer solution, adjust its PH to 6.5, and prepare 2mg / mL dopamine solution. After adding the dopamine solution to the washed calcium carbonate and stirring for 48 hours, the solid particles were collected by centrifugation at 3000 rpm for 3 minutes, and 5 mL of...

Embodiment 2

[0026] Dissolve 45 mg of sodium polystyrene sulfonate (PSS) in 15 mL of filtered calcium chloride solution (concentration of 0.3M), and add 15 mL of filtered 0.3M sodium carbonate solution to the solution at a rotation speed of 1000 rpm React in an electromagnetic stirrer for 20 seconds, let it stand for 20 minutes and then turn on electromagnetic stirring to mix the reaction solution evenly, add 5 mL to the centrifuge tube, and take 4 tubes in total. Centrifuge the 4 tubes of suspension in a centrifuge with a rotating speed of 3000 rpm for 3 minutes and wash with deionized water, and repeat the centrifugation-water washing operation twice.

[0027] Prepare 0.02M Tris-HCl buffer solution, adjust its pH to 7.5, prepare 5mg / mL dopamine solution. After adding the dopamine solution to the washed calcium carbonate and stirring for 24 hours, the solid particles were collected by centrifugation at 3000 rpm for 3 minutes, 5 mL of Tris-HCl buffer solution was added to each centrifuge tube...

Embodiment 3

[0029] Dissolve 36 mg of sodium polystyrene sulfonate (PSS) in 15 mL of filtered calcium chloride solution (with a concentration of 0.4M), and add 15 mL of filtered 0.4M sodium carbonate solution to the solution at a rotation speed of 1000 rpm React in the electromagnetic stirrer for 30 seconds, turn off the electromagnetic stirring and let it stand for 25 minutes, then turn on the electromagnetic stirring, stir the reaction solution evenly, add 5 mL to the centrifuge tube, and take 4 tubes in total. Centrifuge the 4 tubes of suspension in a centrifuge with a rotating speed of 3000 rpm for 3 minutes and then wash with deionized water, and repeat the centrifugation-washing operation twice.

[0030] Prepare 0.1M Tris-HCl buffer solution, adjust its pH to 8.5, and prepare 8mg / mL dopamine solution. After adding the dopamine solution to the washed calcium carbonate and stirring for 8 hours, the solid particles were collected by centrifugation at 3000 rpm for 3 minutes, and 5 mL of Tri...

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Abstract

The invention relates to polydopamine microcapsules and a preparation method thereof. The polydopamine microcapsules are prepared from dopamine serving as a raw material and calcium carbonate particles serving as templates in a mass ratio of 0.1:1-10:1. The preparation method comprises the following steps of: preparing the calcium carbonate particles serving as the templates; adsorbing the dopamine on the templates so as to form polydopamine membranes on the templates by the self-polymerization of the dopamine; reacting for a certain period of time; and removing a calcium carbonate kernel by using ethylene diamine tetraacetic acid disodium after the polydopamine membranes on the templates reaches a certain thickness. For the microcapsules prepared by the method, a preparation process is simple and is convenient to operate, an acid-base catalyst and an organic solvent are saved, the raw material is readily available, the thickness of each membrane is easy to control through the assembly of different layers, the size of each particle is controllable, stability and repeatability are high and a wide application range is achieved.

Description

Technical field [0001] The invention relates to the preparation of a polymer material, and is a polydopamine microcapsule and a preparation method, in particular to the preparation of a polydopamine microcapsule under biological inspiration and a preparation method. Background technique [0002] Nowadays, microcapsules are increasingly used in the fields of microreactors, drug carriers, cell and enzyme embedding protection, and gene transfection. There are mainly three traditional methods for preparing microcapsules: (1) Chemical method, which refers to a method in which a chemical reaction occurs in a liquid phase to form a capsule. At present, there are mainly two kinds of chemical methods, namely, the interface polycondensation method and the radiation chemical method. Although microcapsules of relatively uniform size can be obtained, their size is often difficult to adjust. (2) Physical and chemical method. This method forms capsules in the liquid phase, that is, in the mix...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/14
Inventor 姜忠义张蕾石家福
Owner TIANJIN UNIV
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