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Preparation method of fluorocarbon nanometer medicine-carrying preparation using block copolymer as carrier

A technology of block copolymers and fluorocarbons, which is applied in the direction of drug combinations, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve problems such as instability of liposome preparations, and improve effective utilization and production costs. The effect of low cost and simple preparation process

Inactive Publication Date: 2011-04-13
SHANGHAI NAT ENG RES CENT FORNANOTECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, liposome preparations are unstable, exposure to oxygen, light, etc. will cause oxidative degradation of phospholipids

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: In parts by weight, the formula is as follows:

[0021] 100 parts of water

[0022] Pluronic P123 20 copies

[0023] 5 parts n-hexanol

[0024] Tu-80 1 copy

[0025] 10 parts absolute ethanol

[0026] FC-77 10 parts

[0027] Preparation Process:

[0028] ①In a 50 ml reaction bottle, dissolve 20 parts of block copolymer Pluronic P123 in 100 parts of water, then add 5 parts of n-hexanol, 1 part of Tu-80, 10 parts of absolute ethanol, ultrasonically vibrate, and let stand 2 hours, formulated as an emulsion.

[0029] ② Add 10 parts of FC-77 to the reaction solution prepared according to step ①, stir for 10 minutes at 65 oC, under nitrogen protection and at a speed of 6000 rpm, cool to 25 oC, and stand at this temperature for 24 hours . The solution was then tra...

Embodiment 2

[0033] Example 2: In parts by weight, the formula is as follows:

[0034] 100 parts of water

[0035] Pluronic P123 5 copies

[0036] 10 parts n-butanol

[0037] Triton X-100 10 servings

[0038] Sodium chloride 5 parts

[0039] PFOB 10 copies

[0040] Preparation Process:

[0041] ①In a 50 ml reaction bottle, dissolve 5 parts of block copolymer Pluronic P123 in 100 parts of water, then add 10 parts of n-butanol, 10 parts of Triton X-100, 5 parts of sodium chloride, ultrasonically vibrate, Let it sit for 2 hours to make an emulsion.

[0042] ② Add 10 parts of PFOB to the reaction liquid prepared according to step ①, stir for 20 minutes at 85 oC under nitrogen protection and a speed of 8000 rpm, cool to 25 oC, and stand at this temperature for 36 hours. The solution was then ...

Embodiment 3

[0046] Example 3: In parts by weight, the formula is as follows:

[0047] 100 parts of water

[0048] Pluronic F108 5 copies

[0049]5 parts n-butanol

[0050] Brij-35 1 part

[0051] Calcium chloride 1 part

[0052] 10 parts absolute ethanol

[0053] PFD 1 copy

[0054] Preparation Process:

[0055] ①In a 50 ml reaction bottle, dissolve 5 parts of block copolymer Pluronic F108 in 100 parts of water, then add 5 parts of n-butanol, 1 part of Brij-35, 1 part of calcium chloride, 10 parts of anhydrous Ethanol, ultrasonic vibration, and standing for 2 hours, was prepared into an emulsion.

[0056] ② Add 1 part of PFD to the reaction solution prepared according to step ①, stir for 30 minutes at 60 oC under nitrogen protection and at a speed of 10,000 rpm, cool to 25 oC, and stand...

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Abstract

The invention relates to a preparation method of a fluorocarbon nanometer medicine-carrying preparation using block copolymer as carrier. The method comprises the following specific steps: firstly dissolving block copolymer in water, adding cosurfactant, solubilizer, salt and absolute alcohol, performing ultrasonic vibration, standing to prepare emulsion; secondly adding perfluorocarbon, fully mixing at a certain temperature and under the protection of the injected nitrogen; and standing, and centrifuging to take supernatant and prepare the block copolymer medicine-carrying preparation with the covered perfluorocarbon. The preparation method in the invention is simple, has high maneuverability and can further meet the demands of production and application. The prepared medicine-carrying preparation has the advantages of good physical stability and chemical stability, and better biocompatibility. The prepared block copolymer medicine-carrying preparation can be well used in the rescue medications of anoxia, the magnetic resonance contrast agent and the like.

Description

technical field [0001] The invention relates to a preparation method of a fluorocarbon nanometer drug-loaded preparation, in particular to a preparation method of a fluorocarbon nanometer drug-loaded preparation with a block copolymer as a carrier. Background technique [0002] Perfluorocarbons are blood substitutes with high oxygen-carrying capacity, non-toxicity, and no blood-formed components. It can carry oxygen itself, transport oxygen quickly, and has a volume expansion effect, which can continuously supply oxygen to tissues and improve the hemodynamic status during shock. Infusion of fluorocarbons, when the local blood flow decreases, the increased oxygen-carrying capacity of the blood can partially compensate for the decreased blood flow, maintain the oxygen supply necessary for brain tissue survival and take away carbon dioxide. Because perfluorocarbons do not contain blood formed components, while clearing the microcirculation and ensuring tissue oxygen supply, it...

Claims

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Application Information

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IPC IPC(8): A61K47/34A61K31/02A61K31/335A61K31/451A61P7/08A61K47/10
Inventor 朱君王俊玲刘雪峰王虑张强李文放林兆奋金彩虹何丹农
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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