Preparation method of fluorocarbon nanometer medicine-carrying preparation using block copolymer as carrier

Abstract

The invention relates to a preparation method of a fluorocarbon nanometer medicine-carrying preparation using block copolymer as carrier. The method comprises the following specific steps: firstly dissolving block copolymer in water, adding cosurfactant, solubilizer, salt and absolute alcohol, performing ultrasonic vibration, standing to prepare emulsion; secondly adding perfluorocarbon, fully mixing at a certain temperature and under the protection of the injected nitrogen; and standing, and centrifuging to take supernatant and prepare the block copolymer medicine-carrying preparation with the covered perfluorocarbon. The preparation method in the invention is simple, has high maneuverability and can further meet the demands of production and application. The prepared medicine-carrying preparation has the advantages of good physical stability and chemical stability, and better biocompatibility. The prepared block copolymer medicine-carrying preparation can be well used in the rescue medications of anoxia, the magnetic resonance contrast agent and the like.

Description

technical field

[0001] The invention relates to a preparation method of a fluorocarbon nanometer drug-loaded preparation, in particular to a preparation method of a fluorocarbon nanometer drug-loaded preparation with a block copolymer as a carrier. Background technique

[0002] Perfluorocarbons are blood substitutes with high oxygen-carrying capacity, non-toxicity, and no blood-formed components. It can carry oxygen itself, transport oxygen quickly, and has a volume expansion effect, which can continuously supply oxygen to tissues and improve the hemodynamic status during shock. Infusion of fluorocarbons, when the local blood flow decreases, the increased oxygen-carrying capacity of the blood can partially compensate for the decreased blood flow, maintain the oxygen supply necessary for brain tissue survival and take away carbon dioxide. Because perfluorocarbons do not contain blood formed components, while clearing the microcirculation and ensuring tissue oxygen supply, it...