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Organic-inorganic composite gel material for bone repair and preparation method thereof

A composite gel and organic material technology, applied in medical science, prosthesis, etc., can solve the problems of limited material performance improvement, inability to repair with load-bearing bone, inability to uniformly blend, etc., to achieve good processing performance and good cell compatibility Good effect of sex and fluidity

Inactive Publication Date: 2011-04-13
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since the material needs to be heated to 600°C or above during the preparation process, the material is brittle and cannot be used for the repair of load-bearing bones.
However, the high temperature limits its recombination with organic polymers. Therefore, previous research reports on bioglass and organic polymer composites mostly use the method of physical blending. Polymer materials cannot be uniformly blended with inorganic materials at the molecular level. Limited performance improvements to materials

Method used

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  • Organic-inorganic composite gel material for bone repair and preparation method thereof
  • Organic-inorganic composite gel material for bone repair and preparation method thereof

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preparation example Construction

[0031] The concrete steps of described preparation method are:

[0032] 1) SiO 2 The precursor of tetraethyl orthosilicate, the precursor of CaO calcium chloride and P 2 o 5 The precursor triethyl phosphate is mixed according to the molar fraction of 50-80%, 10-40%, 1-10%, wherein the solvent of ethyl orthosilicate is water, the co-solvent is ethanol, and the hydrolysis catalyst has a mass concentration of 5-10% strong acid solution, the amount of catalyst added is to adjust the pH of the solution to 1-3, and stir evenly;

[0033]2) During the hydrolysis process, add an organic polymer aqueous solution with a mass concentration of 1-20%, so that the mass ratio of the organic component to the inorganic component is 0.1-1:1, and add 0.15-0.25mL catalyst to promote the SiO 2 The formation of a network structure, thus forming an organic-inorganic composite system;

[0034] 3) React the organic-inorganic composite system after adding the catalyst in step 2) for 5-6 minutes, pou...

Embodiment 1

[0037] Stir 12.3ml tetraethyl orthosilicate, 4ml distilled water and 6ml ethanol at room temperature, add hydrochloric acid with a mass concentration of 5% to adjust the pH of the system to about 2. Stir evenly, add 1.2 g of calcium chloride and 0.5 ml of triethyl phosphate into the system, and dissolve completely. Add 5 ml of an aqueous solution of polyglutamic acid with a mass concentration of 10% to the system, so that the mass ratio of polyglutamic acid to ternary inorganic components is 0.12:1, after stirring and mixing, add 0.15 mL of hydrofluoric acid dropwise To promote the polycondensation process, pour the composite system into the mold when it is close to the gel point. After aging at room temperature for about 1 week, freeze in a freeze dryer at -50 °C for 24–48 h, and then vacuum-dry for 4–6 h to remove residual solvents and obtain the desired porous gel material.

Embodiment 2

[0039] Stir 12.3 ml of tetraethyl orthosilicate, 4 ml of distilled water and 6 ml of ethanol at room temperature, and add 10% hydrochloric acid to adjust the pH of the system to about 2. After stirring for a period of time, add 3.6 g of calcium chloride and 1.25 ml of triethyl phosphate into the system and dissolve them completely. Add 7 ml of an aqueous solution of polycapropropionamide and polylactide with a mass concentration of 20% to the system so that the mass ratio of the organic component to the ternary inorganic component is 0.25:1. After stirring and mixing, add 0.25 mL of hydrogen dropwise Fluoric acid promotes the polycondensation process, and when it is close to the gel point, the composite system is poured into a mold for molding. After aging and drying at room temperature for about 30 days, the desired porous gel material was obtained.

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Abstract

The invention relates to an organic-inorganic composite gel material for bone repair and a preparation method thereof. The composite gel material is characterized in that the organic material is formed by synthetic polymers or natural polymers; the inorganic material is formed by SiO2, CaO and P2O5 with mole fraction of 50-80%, 10-40% and 1-10% respectively; and the mass ratio of the organic material to the inorganic material is (0.1-1):1. The method is characterized by penetrating the polymer chains with biocompatibility and biodegradability into the SiO2 inorganic network structure to form the semi-interpenetrating structure. In the invention, the good blending of the organic and inorganic components at molecular level is realized, the mechanical property of the materials is simultaneously improved, and the bioactivity of the materials is improved; and the material and preparation method have important development potential in the field of bone defect repair.

Description

technical field [0001] The invention belongs to the field of polymer materials, and more specifically relates to an organic-inorganic composite gel material for bone repair and a preparation method thereof. Background technique [0002] Bones are the scaffolding of the human body, responsible for supporting, protecting, bearing, hematopoietic, storing calcium, and metabolizing functions. They are important tissues and organs of the human body. Although bone tissue has a certain ability to regenerate and self-repair, clinically, large-scale bone defects caused by tumors, trauma, infection, and congenital dysplasia, as well as osteoporosis caused by the increase in life expectancy, exceed the capacity of bone tissue. Self-healing ability requires surgical bone grafting. Currently, there are many bone graft substitutes used clinically, mainly including autologous bone, allogeneic bone and xenograft bone. Autologous bone is the best way to treat bone defects because of its g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/56
Inventor 詹红兵闫福华刘维伍晓红
Owner FUZHOU UNIV
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