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Imidazoles antifungal skin wiping agent and preparation method thereof

An antifungal and imidazole technology, applied in the field of medicine, can solve problems such as poor oral absorption, thrombophlebitis, and high liver toxicity, and achieve the effects of stable properties, refreshing skin for external use, and improved utilization

Inactive Publication Date: 2012-08-08
杭州雷布新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Imidazole antifungal drugs have definite curative effect. They mainly include tablets, injections, capsules, and creams in clinical practice, but there are still a series of problems, such as: high liver toxicity, poor oral absorption, and intravenous use can cause thrombosis. Phlebitis, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054]Accurately weigh 1 g of ketoconazole, 2 g of sodium lauryl sulfonate, 2 g of laurocapram, 5 g of carbomer, 0.5 g of sodium citrate, 0.2 g of sodium dithiocarbamate, 30 g of propylene glycol, and 0.1 g of pine needle powder. g, methionine 1g. Dissolve 5g of carbomer in 30g of water at room temperature, add 4g of xanthan gum, 0.5g of sodium citrate, 0.2g of sodium dithiocarbamate, 0.1g of pine needle powder, and 1g of methionine and stir until dissolved; Dissolve sodium dialkylsulfonate in 24.2ml of water, add 30ml of propylene glycol, mix well, add laurocaprazine, and finally add ketoconazole, stir until clear. Add the above-mentioned carbomer solution into the ketoconazole mixed solution, and continue to stir until the solution becomes a colorless transparent gel, which is the imidazole antifungal skin wipe.

Embodiment 2

[0056] Accurately weigh 2g of miconazole nitrate, 1g of sodium cocoyl sarcosinate, 2g of laurocapram, 3g of carbomer, 3g of carrageenan, 1g of sodium chloride, 0.5g of sodium alkylsulfonate, 30g of propylene glycol, and Carotene 0.2g, glycine 1g. Dissolve 3g of carbomer in 30g of water at room temperature, add 3g of carrageenan, 1g of sodium chloride, 0.5g of sodium alkylsulfonate, 0.2g of carotenoid, and 1g of glycine and stir until dissolved; Dissolve sodium sarcosinate in 26.3ml of water, add 30g of propylene glycol, mix well, add laurocapram, and finally add miconazole nitrate, stir until clear. Add the above carbomer solution into the miconazole nitrate mixed solution, and continue to stir until the solution becomes a colorless transparent gel, which is the imidazole antifungal skin wipe.

Embodiment 3

[0058] Accurately weigh neoconazole (dichlorophenyl imidazole dioxolane chemical name cis-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1- methyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinecarboxylate) 2g, cocamide MEA 3g, 5-methyl-2- Pyrrolone 3g, polyethylene glycol 5g, pectin 6g, magnesium chloride 0.7g, sodium alkylsulfonate 0.5g, carotenoid 0.2g, glycine 1g, glycerin 30g. Dissolve 5g of polyethylene glycol in 30g of water at room temperature, add 6g of pectin, 0.7g of magnesium chloride, 0.5g of sodium alkylsulfonate, 0.2g of carotenoids, 1g of glycine, stir until dissolved and set aside; add 3g of coconut oil Dissolve amide MEA in 18.6ml of water, add 30g of glycerin, mix well, add 5-methyl-2-pyrrolidone, and finally add neoconazole, stir until clear. Add the above-mentioned polyethylene glycol solution into the neoconazole mixed solution, and continue to stir until the solution is colorless and transparent, which is the imidazole antifungal skin wipe.

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PUM

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Abstract

The invention discloses an imidazoles antifungal skin wiping agent which is characterized by comprising the following materials in percent by weight: 0.1-5% of imidazoles antifungal drug, 1-5% of surface active agent, 2-4% of skin penetrant, 3-5% of drug release agent, 30-50% of water-soluble cosolvent, 3-7% of thickener, 0.5-1% of salts, 0.2-0.5% of antistatic agent, 0.1-0.3% of coloring agent, 0.7-1.5% of nutrition agent and the balance of distilled water. The skin wiping agent has the advantages of little viscosity, stable property and stable releasing speed, can enter blood circulation through the skin and has continuous and strong effect on treating fungoid whelk, scurf and the like caused by fungus. The invention also provides a preparation method of the imidazoles antifungal skin wiping agent.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new dosage form of imidazole antifungal drugs, in particular to an antifungal drug skin wipe and a preparation method thereof. Background technique [0002] Fungi are usually conditional pathogens for healthy humans, but when the body's resistance is reduced and external factors are unfavorable, it may cause systemic or local fungal infections. Imidazole antifungal drugs are currently the most commonly used drugs for the treatment of fungal infections in clinical practice, and are widely used in clinical practice. It can be seen from its chemical structure that substituting the imidazole part at its 1 position is necessary for the antifungal activity of this type of drug, and thus various types of imidazole and triazole antifungal drugs can be evolved. The biggest feature of imidazole antifungal drugs is that they are easy to use, have a certain curative effect, and have relatively mild ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K45/00A61K31/496A61K31/4174A61K31/4196A61P31/10A61P17/00A61P17/10
Inventor 傅锦浩陈伟良居保国
Owner 杭州雷布新材料有限公司