Apparatus and methods for nanoparticle generation and process intensification of transport and reaction systems

A technology of reactants and microreactors, applied in chemical instruments and methods, nanotechnology, nanotechnology, etc., can solve problems such as insufficient productivity, lack of scale and general applicability, and achieve high efficiency and cost-effectiveness. High flexibility performance, reducing component damage

Inactive Publication Date: 2011-05-04
MICROFLUIDICS INT
View PDF18 Cites 20 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More recently, methods for the preparation of nanosuspensions by crystallization have been proposed, but these methods exhibit insufficient productivity
In particular, the new method lacks the control needed at each crystallization mechanistic step (nucleation rate to crystal morphology and stabilization), method scalability and general applicability

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Apparatus and methods for nanoparticle generation and process intensification of transport and reaction systems
  • Apparatus and methods for nanoparticle generation and process intensification of transport and reaction systems
  • Apparatus and methods for nanoparticle generation and process intensification of transport and reaction systems

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0129] Example 1: Preparation of norfloxacin nanosuspensions using solvent / anti-solvent crystallization under high shear rate conditions

[0130] Overview: Hydrophobic active pharmaceutical ingredients (APIs) are often difficult to deliver effectively due to formulation constraints. Nanosuspensions of such drugs can be used to enhance bioavailability and provide multiple delivery options, including inhalation, oral, transdermal, and injection. The devices, systems and methods of the present disclosure have been used to reproducibly generate submicron API suspensions through a continuous process involving solvent-antisolvent crystallization. This technique of using miscible fluids to alter the solvent composition to create a supersaturated state is readily commercially implementable. It may also be the best economic choice due to its process-intensive nature that minimizes unit operations and energy requirements. Therefore, it may be the most environmentally friendly of the v...

Embodiment 2

[0185] Example 2: Preparation of Stable Drug Nanosuspensions According to the Disclosure (Extension of Example 1)

[0186] Several active pharmaceutical ingredients (APIs) were tested to further demonstrate the efficacy of the disclosed devices, systems and methods. The median particle size of the suspension produced by the device / system of the present disclosure is in the range of 50-767 nm. The suspensions were stable with one exception. For some APIs, the process efficiency exceeds 80%.

[0187] In contrast to the conventional "top-down" approach to preparing nanosuspensions, which primarily relies on reducing the particle size of drug powders in dry or wet formulations, exemplary embodiments of the present disclosure employ crystallization with solvent and anti-solvent "Bottom-up" processing to generate drug nanosuspensions. The disclosed "bottom-up" process enables the formation and stabilization of nanosuspensions without the need for size reduction. More specificall...

Embodiment 3

[0211] Example 3: Proposed system dynamics for biodiesel synthesis

[0212] Biodiesel can be produced by transesterification of vegetable oils. The most commonly used vegetable oils are soybean oil and canola oil. The reaction is a three-step catalytic reversible reaction. For every mole of triglyceride (TG) reactant (i.e. three fatty acid side groups), three moles of methanol are required to produce three moles of specific fatty acid methyl esters (FAME, referred to as "biodiesel") and one mole of glycerol (G, by-product). However, the reaction was carried out in an excess of methanol (6:1 molar ratio of methanol and vegetable oil) to push the reaction forward. The main reaction scheme is in Figure 17 shown in .

[0213] Typically, the catalyst is sodium hydroxide or sodium methoxide. In either case, the ion responsible for the catalysis is the methoxy ion. When sodium hydroxide is used, the methoxyl ion is generated in situ by reaction with methanol. The reaction me...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

Apparatus, systems and methods are provided that utilize microreactor technology to achieve desired mixing and interaction at a micro and/or molecular level between and among feed stream constituents. Feed streams are fed to an intensifier pump at individually controlled rates, e.g., based on operation of individually controlled feed pumps. The time during which first and second feed streams are combined/mixed prior to introduction to the microreactor is generally minimized, thereby avoiding potential reactions and other constituent interactions prior to micro- and/or nano-scale interactions within the microreactor. Various microreactor designs/geometries may be employed, e.g., ''Z'' type single or multi-slot geometries and ''Y'' type single or multi-slot geometries. Various applications benefit from the disclosure, including emulsion, crystallization, encapsulation and reaction processes.

Description

technical field [0001] The present disclosure relates to devices, systems and methods that facilitate efficient molecular contact / interaction within a defined reaction chamber thereby enhancing and / or facilitating a number of mixing and / or reaction phenomena. More particularly, the disclosed devices, systems and methods are designed to bring together streams of components to be interacted within a defined reaction chamber to achieve highly desired results. Background technique [0002] The role of fluid mechanics should not be underestimated in any aspect of engineering science. The flow regime within a process unit and its associated transport lines has a significant effect on mass, energy and momentum transfer rates and reaction efficiency. Therefore, system design typically benefits from the determination of energy dissipation mechanisms and thus the quantification of mixing strength and contact efficacy. These are often important factors in material processing and prep...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): B82B3/00B01F25/60
CPCB01J19/0093B01J2219/0086B01J2219/00873B01J2219/00889B01J2219/00891Y02P20/582B01F25/23B01F33/30
Inventor 托曼·帕纳吉奥图史蒂文·文森特·梅西特罗伯特·约翰·菲舍尔
Owner MICROFLUIDICS INT
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap