Niclosamide membrane spreading oil and preparation method and applications thereof

The technology of niclosamide and film-spreading oil is applied in the field of prevention and control of schistosomiasis, and can solve the problems of easily polluted environment, unfriendly environment, and low efficacy of wettable powder, and achieves the effects of easy use and low comprehensive cost.

Active Publication Date: 2011-05-11
JIANGSU ESSENCE AGROCHEM
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Niclosamide, as the first choice drug for molluscicide, is the only molluscicide recommended by the World Health Organization for on-site use. It has the advantages of good molluscicide effect and low toxicity to mammals and plants. It has been promoted and used on a large scale for many years, but it is mostly limited to killing snails, and there are few studies on killing schistosomes
The formulations currently available in the market for the prevention and control of oncomelania mainly include wettable powder, emulsifiable concentrate, and suspension concentrate. Compared with film-spreading oils, the traditional formulations all have a large amount of preparation per unit, which increases the enviro

Method used

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  • Niclosamide membrane spreading oil and preparation method and applications thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: 1% niclosamide film developing oil

[0021] Take niclosamide 1% by mass percentage, solvent cyclohexanone 6%, fatty alcohol polyoxyethylene ether 4%, sorbitan fatty acid ester polyoxyethylene ether 5%, n-butanol 4%, oleic acid methyl The ester is supplemented to 100% and the niclosamide is completely dissolved in the solvent under stirring at a temperature of 50-60° C. and a rotation speed of 50-100 rpm to obtain a 1% niclosamide film developing oil.

[0022] The prepared niclosamide film spreading oil was transparent in appearance, and there was no precipitation, crystallization and delamination after heat storage (54°C±2°C) for 14 days and low temperature storage (0°C±2°C) for 7 days, and the decomposition rate was 1.2% . The surface tension at 35°C is 21.7mN / m, and the oil / water interfacial tension when dripping on the water surface is 0.11mN / m; it can spread rapidly on the water surface. When the dripping amount is 3.6μL, the spreading speed is 10.4cm...

Embodiment 2

[0023] Embodiment 2: 2.5% niclosamide film developing oil

[0024] Take niclosamide 2.5% by mass percentage, solvent cyclohexanone 15%, fatty alcohol polyoxyethylene ether 4%, sorbitan fatty acid ester polyoxyethylene ether 4%, castor oil ethylene oxide adduct 2%, film-forming aid isoamyl alcohol 5%, methyl oleate to make up to 100%, at a temperature of 50-60 ° C, under stirring at a speed of 50-100rpm, niclosamide is completely dissolved in the solvent to obtain 2.5% Niclosamide film developing oil.

[0025] The prepared niclosamide film spreading oil was transparent in appearance, and there was no precipitation, crystallization and delamination after heat storage (54°C±2°C) for 14 days and low temperature storage (0°C±2°C) for 7 days, and the decomposition rate was 1.8% . The surface tension at 35°C is 24.1mN / m, and the oil / water interfacial tension when dripping on the water surface is 0.17mN / m; it can spread rapidly on the water surface, and the spreading speed is 8.2cm / ...

Embodiment 3

[0026] Embodiment 3: 5% niclosamide film developing oil

[0027] Take niclosamide 5% by mass percentage, solvent acetone 20%, fatty alcohol polyoxyethylene ether 4%, sorbitan fatty acid ester polyoxyethylene ether 6%, tristyrylphenol polyoxyethylene ether 6% , 5% of film-forming aid n-hexanol, supplemented with vegetable soybean oil to 100%, at a temperature of 50-60°C and a stirring speed of 50-100rpm, niclosamide is completely dissolved in the solvent to obtain 5% niclosamide Spread film oil.

[0028] The prepared niclosamide film spreading oil has a transparent appearance, no precipitation, crystallization and stratification after 14 days of heat storage (54 °C ± 2 °C) and 7 days of low temperature storage (0 °C ± 2 °C), and the decomposition rate is 1.5% . The surface tension at 35°C is 26.7mN / m, and the oil / water interfacial tension when dripping on the water surface is 0.25mN / m; it can spread rapidly on the water surface, and the spreading speed is 7.8cm / s when the dri...

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Abstract

The invention discloses niclosamide membrane spreading oil and a preparation method and applications thereof. The niclosamide membrane spreading oil comprises the following components in mass percent: 1-10% of niclosamide, 5-25% of solvent, 1-20% of nonionic surface active agent, 1-10% of membrane forming assistant agent and the rest of oleic acid ester. The product of the invention is a new-typepesticide formulation which is dropwise applied on the water surface in ultralow volume, is not emulsified and is not dissolved; liquid medicine rapidly spreads into a membranoid substance when touching the water surface; a membrane agent passes through a series of physical processes, such as phase changing and the like, after spreading; and the medicine floats on the water surface in the particles, and the grain diameter of which is less than 0.1 micron. The niclosamide membrane spreading oil has the characteristics of high efficiency, environmental protection, low toxicity, broad spectrum, safety, very simple and convenient use, energy saving and labor saving, no needing of any apparatus, capability of being directly dropwise applied on the surface of water, and low comprehensive cost and the like.

Description

technical field [0001] The invention belongs to the field of preventing and treating schistosomiasis, and in particular relates to a new preparation of niclosamide for killing cercariae of Schistosoma japonicum. Background technique [0002] The life cycle of schistosomiasis is divided into seven stages: adult, egg, miracidium, mother sporozoite, sporozoite, cercariae, and juvenile worm. The intermediate host is the snail, and the mammal is the ultimate host. The final host, intermediate host and the external environment in which they live together constitute the environmental chain for the survival and reproduction of schistosomes. [0003] Niclosamide, as the first choice drug for molluscicide, is the only molluscicide recommended by the World Health Organization for on-site use. It has the advantages of good molluscicide effect and low toxicity to mammals and plants. It has been popularized and used on a large scale for many years, but it is mostly limited to killing sn...

Claims

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Application Information

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IPC IPC(8): A01N37/40A01N25/02A01P9/00
Inventor 朱光飞梁晓天张申伟郭家钢
Owner JIANGSU ESSENCE AGROCHEM
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