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Doxycycline hydrochloride effervescent tables for milk cows and preparation method thereof

A technology for doxycycline hydrochloride and effervescent tablets, which is applied in the field of doxycycline hydrochloride effervescent tablets for dairy cows and its preparation, and can solve the problems of poor solubility, small contact area between uterine mucous membrane and vagina, and unsatisfactory therapeutic effect , to achieve the effect of improved antibacterial effect, good effect and quick effect

Active Publication Date: 2011-05-18
ZHENGZHOU BARY ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the treatment of vaginal and uterine diseases of dairy cows, vaginal and uterine perfusion are often used. However, due to the poor solubility of the above dosage forms and the small contact area with the uterine mucosa and vagina, the overall therapeutic effect is not ideal.

Method used

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  • Doxycycline hydrochloride effervescent tables for milk cows and preparation method thereof
  • Doxycycline hydrochloride effervescent tables for milk cows and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The effervescent tablet of doxycycline hydrochloride for dairy cows of this example includes the following components in weight percentage: (according to the ratio of raw and auxiliary materials of 1000 doxycycline hydrochloride effervescent tablets, a single tablet weighs 20 g):

[0023] Doxycycline hydrochloride 1100g

[0024] Tartaric acid 4200g

[0025] Sodium bicarbonate 5800g

[0026] Polyvinylpyrrolidone 1500g

[0027] Polyethylene glycol 6000 800g

[0028] Anhydrous glucose 6500g

[0029] Magnesium stearate 100g

[0030] The specific preparation steps are:

[0031] (1) Dry doxycycline hydrochloride, tartaric acid, sodium bicarbonate, polyethylene glycol 6000, anhydrous dextrose, pass through an 80 mesh sieve, and set aside;

[0032] (2) Weigh the components in step (1) and mix them in equal increments to form a powder mixture;

[0033] (3) Dissolve polyvinylpyrrolidone in a 95% ethanol solution, mix well, and set aside;

[0034] (4) Evenly spray the ethanol solution of polyvinyl...

Embodiment 2

[0040] The effervescent tablet of doxycycline hydrochloride for dairy cows of this example includes the following components in weight percentage: (according to the ratio of raw and auxiliary materials of 1000 doxycycline hydrochloride effervescent tablets, a single tablet weighs 20 g):

[0041] Doxycycline hydrochloride 2300g

[0042] Tartaric acid 4200g

[0043] Sodium bicarbonate 5800g

[0044] Polyvinylpyrrolidone 1500g

[0045] Polyethylene glycol 6000 800g

[0046] Anhydrous glucose 5300g

[0047] Magnesium stearate 100g

[0048] The specific preparation steps are:

[0049] (1) Dry doxycycline hydrochloride, tartaric acid, sodium bicarbonate, polyethylene glycol 6000, anhydrous dextrose, pass through an 80 mesh sieve, and set aside;

[0050] (2) Weigh the components in step (1) and mix them in equal increments to form a powder mixture;

[0051] (3) Dissolve polyvinylpyrrolidone in a 95% ethanol solution, mix well, and set aside;

[0052] (4) Evenly spray the ethanol solution of polyvi...

Embodiment 3

[0058] The effervescent tablet of doxycycline hydrochloride for dairy cows of this example includes the following components in weight percentage: (according to the ratio of raw and auxiliary materials of 1000 doxycycline hydrochloride effervescent tablets, a single tablet weighs 20 g):

[0059] Doxycycline hydrochloride 3100g

[0060] Tartaric acid 4200g

[0061] Sodium bicarbonate 5800g

[0062] Polyvinylpyrrolidone 1500g

[0063] Polyethylene glycol 6000 800g

[0064] Anhydrous glucose 4500g

[0065] Magnesium stearate 100g

[0066] The specific preparation steps are:

[0067] (1) Dry doxycycline hydrochloride, tartaric acid, sodium bicarbonate, polyethylene glycol 6000, anhydrous dextrose, pass through an 80 mesh sieve, and set aside;

[0068] (2) Weigh the components in step (1) and mix them in equal increments to form a powder mixture;

[0069] (3) Dissolve polyvinylpyrrolidone in a 95% ethanol solution, mix well, and set aside;

[0070] (4) Evenly spray the ethanol solution of polyvinyl...

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Abstract

The invention belongs to the technical field of medicine preparation, and relates to doxycycline hydrochloride effervescent tables for milk cows and a preparation method thereof. The effervescent tables comprise the following components in percentage by weight: 5-20% of doxycycline hydrochloride, 10-30% of tartaric acid, 15-45% of sodium bicarbonate, 1-15% of polyvinyl pyrrolidone, 1-10% of polyethylene glycol 6000, 20-50% of anhydrous glucose, and 0.01-3% of magnesium stearate. The preparation method comprises the following steps: pretreating raw materials, mixing, preparing damp mass, granulating, drying, grading, and tabletting. The doxycycline hydrochloride effervescent tables have the advantages of good effect, strong stability, and the like, and are convenient to carry and use.

Description

Technical field [0001] The invention belongs to the technical field of medicine preparation, and particularly relates to a doxycycline hydrochloride effervescent tablet for dairy cows and a preparation method thereof. Background technique [0002] In recent years, with the development of the dairy farming industry, dairy cow endometritis, vaginitis, pyometra, postpartum infections, infertility and other vaginal and uterine diseases caused by pathogenic microorganisms such as bacteria, fungi, mycoplasma, and viruses have gradually increased. This has caused huge economic losses to the dairy farming industry. Therefore, it is urgent to strengthen the prevention and treatment of vaginal and uterine diseases in dairy cows to ensure the healthy and sustainable development of the dairy farming industry, thereby improving the economic benefits of the dairy farming industry. [0003] The chemical name of doxycycline hydrochloride is 6-methyl-4-(dimethylamino)-3,5,10,12,12α, -pentahydroxy-1...

Claims

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Application Information

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IPC IPC(8): A61K9/46A61K31/65A61K47/34A61P31/02A61P15/02A61P15/00A61K47/10A61K47/32
Inventor 郭玉凡陈盟张宁周衡王佳伟
Owner ZHENGZHOU BARY ANIMAL PHARMA
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