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Medical titanium or titanium alloy surface activation modifying method

A technology of surface activation and surfactant, which is applied in medical science, prosthesis, coating, etc., can solve the problems of narrow selection range of matrix materials and reliability problems, and achieve rich physical and chemical properties, improve biological activity, and large ratio The effect of surface energy

Inactive Publication Date: 2011-06-22
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] In order to solve the problem of the reliability of the bone-implant interface, Kokubo proposed a biomimetic method, first pretreating the titanium surface, and then heating it to obtain titanium dioxide on the surface, and the titanium hydroxyl (Ti-OH) on the surface can be used under biomimetic conditions. However, the crystalline titanium dioxide layer is obtained by oxidation of the titanium matrix itself, and at the same time, it is limited by high temperature heating conditions, so that the selection range of the matrix material is very narrow, and the shape of the titanium matrix material is also very strict. requirements

Method used

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  • Medical titanium or titanium alloy surface activation modifying method
  • Medical titanium or titanium alloy surface activation modifying method
  • Medical titanium or titanium alloy surface activation modifying method

Examples

Experimental program
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Effect test

Embodiment 1

[0037] 350ml of surfactant sodium styrene sulfonate (PSS) and 21g of polystyrene microspheres (PS) were thoroughly ultrasonically mixed to obtain a 0.06g / ml modified polystyrene microsphere dispersion.

[0038] 1.02g of H 2 o 2 (30%wt) was added into 300ml deionized water and mixed well to obtain 0.03mol / L of H 2 o 2 aqueous solution. Take 1.44g of TiOSO 4 Add 0.03mol / L of H to the powder 2 o 2 Aqueous solution, prepared 0.03mol / L TiOSO 4 , 0.03mol / L H 2 o 2 mixture.

[0039] The sample is pure titanium with a size of 10×10×1 mm, which is cleaned and used for later use. Take the above 0.03mol / L TiOSO 4 , 0.03mol / L H 2 o 2 30 ml of the mixed solution was added, 20 ml of the above-mentioned polystyrene microsphere (PS) dispersion modified with the surfactant sodium styrene sulfonate was added, and the treatment solution was obtained by fully ultrasonically mixing. Heat the treatment solution to 100°C and keep it at this temperature, immerse the titanium sheet in th...

Embodiment 2

[0041] The sample is pure titanium with a size of 10×10×1 mm, which is cleaned and used for later use. Get the 0.03mol / LTiOS0 that makes in embodiment 1 4 , 0.03mol / L H 2 o 2 30ml of the mixed solution was added to 20ml of the polystyrene microsphere (PS) dispersion modified with the surfactant sodium styrene sulfonate prepared in Example 1, and fully ultrasonically mixed to obtain a treatment solution. Heat the treatment solution to 80°C and keep it at this temperature, immerse the titanium sheet in the treatment solution for 0.5 hours, and use a high-pressure mercury lamp with a power of 1000W and a light intensity of 65±5w / m at 254nm 2 , irradiated with ultraviolet light for 0.5 hours, then removed the ultraviolet light source, then soaked the titanium sheet in the treatment solution at 80°C for 35.5 hours, took it out and immersed it in 50ml of tetrahydrofuran for 0.5 hours to remove polystyrene, took it out to remove polystyrene The ethylene substrate was washed with d...

Embodiment 3

[0043] The sample is pure titanium with a size of 10×10×1 mm, which is cleaned and used for later use. Get the 0.03mol / LTiOS0 that makes in embodiment 1 4 , 0.03mol / L H 2 o 2 30ml of the mixed solution was added to 20ml of the polystyrene microsphere (PS) dispersion modified with the surfactant sodium styrene sulfonate prepared in Example 1, and fully ultrasonically mixed to obtain a treatment solution. Heat the treatment solution to 60°C and keep it at this temperature, immerse the titanium sheet in the treatment solution for 0.5 hours, and use a high-pressure mercury lamp with a power of 1000W and a light intensity of 65±5w / m at 254nm 2 , irradiated with ultraviolet light for 0.5 hours, then removed the ultraviolet light source, then soaked the titanium sheet in the treatment solution at 60°C for 35.5 hours, took it out and soaked it in 50ml of tetrahydrofuran for 0.5 hours to remove polystyrene, took it out to remove polystyrene The ethylene substrate was washed with dei...

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Abstract

The invention relates to a medical titanium or titanium alloy surface activation modifying method which comprises the steps of: 1, with a surfactant modified monodisperse polystyrene (PS) sphere as a template and an inorganic titanium salt water solution as a precursor solution, preparing a processing solution; 2, with pure titanium or titanium alloy as a matrix, immersing the pure titanium or titanium alloy in the processing solution, and keeping the temperature of the processing solution to be 60-100 DEG C for 24-50h, wherein UV-irradiation is carried out within at least 0.25-2h, and the matrix is soaked in the processing solution with the temperature of 60-100 DEG C; and taking the soaked matrix out, immersing into an organic solvent capable of dissolving the PS for soaking to remove the PS, soaking and crystallizing in deionized water, and completing the deposition of a film. The self-assembling nano crystal titanium dioxide microcapsule biological film is prepared by using the monodisperse polystyrene sphere as the template and the low-price inorganic titanium salt as the raw material at low temperature through a hydrolysis-sol method, and has better bioactivity.

Description

(1) Technical field [0001] The invention relates to a method for surface activation modification of medical titanium or titanium alloy, which improves surface biological activity through the modified titanium or titanium alloy. (2) Background technology [0002] Titanium and its alloys are biologically inert materials in nature, and there is only a mechanical fit with bone, rather than a strong chemical osseointegration. Therefore, the formation of a good titanium implant-bone tissue interface is important to ensure the success of implant repair. Factors, but also a key issue faced by this type of transplant surgery. Studies in recent years have shown that changing the structure and chemical composition of titanium surface oxide film through physical, chemical and electrochemical surface modification methods can endow titanium metal with biological activity, thereby realizing the bioactive combination between materials and hard tissues in vivo. [0003] In 1992, Cotell et a...

Claims

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Application Information

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IPC IPC(8): A61L27/30A61L27/06
Inventor 肖帆张智贤高飞李伟
Owner ZHEJIANG UNIV OF TECH
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