Preparation method of biological function composite auxetic hydrogel with shell core structure

A hydrogel and biological technology, applied in medical science, prosthesis, etc., can solve the problems of research reports, lack of clear understanding of auxetic properties and mechanism, and achieve the effect of enhancing cross-linking effect and controllable performance.

Inactive Publication Date: 2011-06-29
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although it was discovered as early as 100 years ago that the skin, blood vessels, bones and other tissues of some parts of animals have auxetic effects, there is also axetic effect in biofilms with protein skel

Method used

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  • Preparation method of biological function composite auxetic hydrogel with shell core structure
  • Preparation method of biological function composite auxetic hydrogel with shell core structure
  • Preparation method of biological function composite auxetic hydrogel with shell core structure

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0029] Step 1: Mix hyaluronic acid (HA) solid particles with deionized water to make a HA water-based suspension with a mass fraction of HA of 20%, put it into a pressure steam container and heat to dissolve, and the pressure in the container is maintained at 0.10 MPa , the temperature is 120°C, and the heating time is 1.5 hours. Then take out the homogeneously dissolved HA polymer sol, and let it stand for cooling.

[0030] Step 2: Inject the above sol into a stainless steel cylindrical mold with an inner diameter of 10.00mm, and perform a freeze-thaw cycle treatment: freeze temperature -30°C, freeze time for 8 hours, and then thaw at room temperature for 8 hours, so freeze-thaw cycle 6 times, The core structure was cut into a cylinder with a height of 20.00 mm as the core, thereby obtaining the core structure of the biofunctional composite auxetic hydrogel with a shell-core structure.

[0031] Step 3: Weigh a certain amount of PVA solid particles and add them to deionized w...

example 2

[0034] Step 1: Add analytically pure polyvinylpyrrolidone (PVP) particles into deionized water to prepare a water-based suspension with a mass percentage of PVP of 25%, stir evenly in a constant temperature water bath at 60°C until the PVP dissolves, and let stand to cool. Obtain PVP polymer sol.

[0035] Step 2: inject the above-mentioned sol into a stainless steel cylinder mold with an inner diameter of 20.00 mm, and place it in a gamma ray radiation field for radiation treatment with a dose of 20 kGy to obtain a green body, which is cut into a cylinder with a height of 20.00 mm as core body, thereby obtaining the core body structure of the biofunctional composite auxetic hydrogel having a shell-core structure.

[0036] Step 3: Weigh a certain amount of PVP solid particles and add them to deionized water to prepare a water-based suspension with a mass fraction of 15%. After stirring to make it fully mixed, stir in a constant temperature water bath at 90°C until the PVP solid p...

example 3

[0039] Step 1: Mix polyvinyl alcohol (PVA) solid particles with deionized water to make a PVA water-based suspension with a PVA mass fraction of 35%, put it into a pressure steam container and heat to dissolve, and the pressure in the container is maintained at 0.15 MPa , the temperature was 110°C, and the heating time was 2 hours. Then the homogeneously dissolved PVA polymer sol is taken out and allowed to stand for cooling.

[0040] Step 2: Inject the above-mentioned sol into a stainless steel cylinder mold with an inner diameter of 20.00mm, and perform freeze-thaw cycle treatment: freeze temperature -20°C, freeze time for 10 hours, and then thaw at room temperature for 10 hours, so freeze-thaw cycle 8 times, The core structure was cut into a cylinder with a height of 25.00 mm as the core, thereby obtaining the core structure of the biofunctional composite auxetic hydrogel with a shell-core structure.

[0041] Step 3: Weigh a certain amount of PVA solid particles and add th...

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Abstract

The invention belongs to the field of biomedical material and relates to a preparation method of biological function composite auxetic hydrogel with shell core structure. In the method, the biological function composite auxetic hydrogel with shell core structure is prepared by the radiation cross-linking technology or freezing/unfreezing method, i.e. an inner core is of a dense structure with lowwater content, and an outer shell is of a communicated porous structure with relatively low modulus. Macroscopically, a negative Poisson's ratio effect of the material is realized, and the inner coreand outer shell are in firm combination. By controlling the core component and size as well as the shell composition and structure of the material, the auxetic hydrogel meeting various application requirements can be prepared; by controlling the radiation dosage in the radiation cross-linking as well as the parameters of the freezing/unfreezing process such as temperature, time, circulation timesand the like, the condensed state structure and crystallization degree of the polymer can be changed so as to prepare the biological function composite auxetic hydrogel with controllable performance.The biological function composite auxetic hydrogel is suitable for the bionic implantation repair material for the soft tissues such as blood vessels, nerves, cartilage, intervertebral disk, muscles,ligaments and the like.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to the preparation of biofunctional composite auxetic hydrogel suitable for bionic implantation and repair materials of soft tissues such as blood vessels, nerves, cartilage, intervertebral discs, muscles and ligaments. Background technique [0002] Auxetic materials have a special microstructure and unique mechanical properties different from ordinary materials, that is, when stretched, they expand laterally within the elastic range; when compressed, the material shrinks laterally. Since Lakes first discovered in 1987 that the two-dimensional honeycomb solid material composed of concave cell structure units has a negative Poisson’s ratio, a variety of auxetic polymers with different microstructures and deformation mechanisms have been discovered and prepared, mainly including Porous auxetic polymers, auxetic composite materials and molecular auxetic polymers have made great brea...

Claims

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Application Information

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IPC IPC(8): A61L27/52A61L27/16A61L27/18A61L27/20A61L27/22A61L27/24
Inventor 郑裕东马衍轩孟昊业姚学锋吕鹤翔刘国权
Owner UNIV OF SCI & TECH BEIJING
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