Preparation method of biological function composite auxetic hydrogel with shell core structure

Abstract

The invention belongs to the field of biomedical material and relates to a preparation method of biological function composite auxetic hydrogel with shell core structure. In the method, the biological function composite auxetic hydrogel with shell core structure is prepared by the radiation cross-linking technology or freezing / unfreezing method, i.e. an inner core is of a dense structure with lowwater content, and an outer shell is of a communicated porous structure with relatively low modulus. Macroscopically, a negative Poisson's ratio effect of the material is realized, and the inner coreand outer shell are in firm combination. By controlling the core component and size as well as the shell composition and structure of the material, the auxetic hydrogel meeting various application requirements can be prepared; by controlling the radiation dosage in the radiation cross-linking as well as the parameters of the freezing / unfreezing process such as temperature, time, circulation timesand the like, the condensed state structure and crystallization degree of the polymer can be changed so as to prepare the biological function composite auxetic hydrogel with controllable performance.The biological function composite auxetic hydrogel is suitable for the bionic implantation repair material for the soft tissues such as blood vessels, nerves, cartilage, intervertebral disk, muscles,ligaments and the like.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to the preparation of biofunctional composite auxetic hydrogel suitable for bionic implantation and repair materials of soft tissues such as blood vessels, nerves, cartilage, intervertebral discs, muscles and ligaments. Background technique [0002] Auxetic materials have a special microstructure and unique mechanical properties different from ordinary materials, that is, when stretched, they expand laterally within the elastic range; when compressed, the material shrinks laterally. Since Lakes first discovered in 1987 that the two-dimensional honeycomb solid material composed of concave cell structure units has a negative Poisson’s ratio, a variety of auxetic polymers with different microstructures and deformation mechanisms have been discovered and prepared, mainly including Porous auxetic polymers, auxetic composite materials and molecular auxetic polymers have made great brea...

AI Technical Summary

Problems solved by technology

However, although it was discovered as early as 100 years ago that the skin, blood vessels, bones and other tissues of some parts of animals have auxetic effects, there is also axetic effect in biofilms with protein skeletons.

However, its auxetic properties and mechanism have not been clearly understood, and so far there has been no research report on the specific structure and auxetic properties of the gel state of synthetic materials.

Images