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Kiwi soft capsule preparation method with functions of regulating immunity and inhibiting tumors

A technology for regulating immunity and kiwi fruit, applied in the directions of capsule delivery, anti-tumor drugs, medical preparations containing active ingredients, etc. , excellent and convenient anti-cancer adjuvant therapy health care products, the effect of beautiful appearance

Inactive Publication Date: 2011-08-10
赵正福
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such as: Patent No.: CN1107308 "kiwi fruit natural nutrition oral liquid" and CN1413525A, the patent "A kind of kiwi fruit anti-aging oral liquid" on April 30, 2003, and CN1184612A, the patent "anti-cancer wild kiwi fruit vitamin drink" on June 17, 1998 and its preparation process", etc., are all prepared by blending kiwi fruit juice with other nutrients, vitamins, etc., but there are insufficient researches on the preservation of nutritional active substances of kiwi fruit itself, preparations and functional applications that are easy to use, and it is not easy to store and carry. And taking, it is difficult to achieve better health function

Method used

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  • Kiwi soft capsule preparation method with functions of regulating immunity and inhibiting tumors
  • Kiwi soft capsule preparation method with functions of regulating immunity and inhibiting tumors
  • Kiwi soft capsule preparation method with functions of regulating immunity and inhibiting tumors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Kiwi fruit freeze-dried powder

[0022] Peel 50kg of kiwi fruit (commercially available), slice, pre-freeze to -20°C for 2 hours, turn on the vacuum pump, the vacuum degree reaches 0.1mmHg, turn off the freezer, keep the vacuum during sublimation drying, and slowly heat up the drying chamber to 20°C ℃, about 24 hours; when re-drying, raise the temperature to 25 ℃, keep it for 2 hours, freeze-dried the product, and ultrafinely pulverize it through a 200-mesh sieve at a temperature of ≤ 25 ℃.

[0023] (2) Chia polysaccharide

[0024] Decoct the kiwifruit peel in water for two times, the first time for 2 hours, the second time for 1.5 hours, combine the second decoction, filter, concentrate the filtrate to a specific gravity of 1.15, add ethanol until the alcohol content is 70% (v / v), and filter Precipitated, drained, washed once with ethanol, dried in vacuum, ultrafinely crushed and passed through a 200-mesh sieve to obtain the product.

[0025] (3) Soft capsule pre...

Embodiment 2

[0031] (1) Kiwi fruit freeze-dried powder

[0032] Peel 50kg of kiwi fruit (commercially available), slice, pre-freeze to -25°C for 3 hours, turn on the vacuum pump, the vacuum degree reaches 0.1mmHg, turn off the freezer, keep the vacuum during sublimation drying, and slowly heat up the drying room to 25°C ℃, about 18 hours; when re-drying, raise the temperature to 30 ℃, keep it for 4 hours, freeze-dried the product, ultrafinely grind it through a 250-mesh sieve, and obtain it.

[0033] (2) Chia polysaccharide

[0034] Chinese kiwifruit peel is decocted twice, the first time is 3 hours, the second time is 2 hours, the second decoction is combined, filtered, the filtrate is concentrated to a specific gravity of 1.8, and ethanol is added to the alcohol content of 90% (v / v), filtered Precipitated, drained, washed once with ethanol, dried in vacuum, ultrafinely pulverized and passed through a 250-mesh sieve.

[0035] (3) Soft capsule preparation

[0036] Kiwi fruit freeze-drie...

Embodiment 3

[0041] Effect of Kiwiguo Soft Capsules on the Phagocytosis of Peritoneal Macrophages in Mice

[0042] 1 Purpose of the experiment: To observe the effect of kiwi fruit soft capsule on the phagocytic function of peritoneal macrophages in mice.

[0043] 2 Test drugs:

[0044] Drug name: kiwi fruit soft capsule (sample of embodiment 1)

[0045] 3 experimental animals

[0046] Kunming mice, ♂ sex, 18-20g, provided by Shanghai Slack Animal Co., Ltd. Certificate number: SCXK (Shanghai) 2003-0003

[0047] 4 experimental doses

[0048] The designed experimental dosage is: 0.5g / kg; 1.5g / kg

[0049] 5 Positive Drugs

[0050] Name: Yunzhi Glycopeptide Capsules (commercially available)

[0051] Specification: 0.34g / grain

[0052] Usage and dosage: 3 capsules each time, 3 times a day.

[0053] Experimental dose: 1g / kg

[0054] 6 Administration route and capacity

[0055] Oral administration, 0.5ml / 20g.

[0056] 7 Experimental methods

[0057] The mice were randomly divided into...

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Abstract

The invention relates to a kiwi soft capsule preparation method with the functions of regulating immunity and inhibiting tumors. The method comprises the following steps: (1) peeling kiwi fruits, slicing, pre-freezing, gradually heating, drying and crushing to obtain kiwi freeze-dried powder; (2) frying peels of the kiwi fruits with water, filtering, concentrating a filtrate, adding ethanol into the filtrate, filtering a precipitate, drying up, cleaning, drying and crushing to obtain kiwi polysaccharide; and (3) uniformly mixing the kiwi freeze-dried powder, the kiwi polysaccharide and olive oil at the temperature of between 40 and 50 DEG C to prepare the soft capsules. Comprehensive nutrition and active components in the kiwi fruits are maintained by adopting an advanced technology in a low temperature and vacuum condition; the soft capsules have an excellent function of isolating light and oxygen and an excellent visual effect, have the characteristics of high bioavailability, accurate content, good uniformity, nice appearance, small dosage and the like, and can regulate the immunity and remarkably improve the function of natural killer (NK) cells for killing cancer cells, so that an excellent and convenient anticancer treatment-assistance health-care product is provided to tumor patients.

Description

technical field [0001] The invention belongs to the field of preparation of kiwifruit soft capsules, in particular to a preparation method of kiwifruit soft capsules with the function of regulating immunity and suppressing tumors. Background technique [0002] Among the 27 most popular fruits ranked by the American Food Research Center, kiwifruit tops the list, and its nutritional value ranks first: kiwifruit is rich in nutrients including: vitamin C (ascorbic acid), β-carotene, vitamin E. Glutathione, chlorophyll, arginine, polysaccharide polyphenols, actinine, etc., have the highest nutrition, and the percentage of Daily Value per 100 grams of fruit is the highest among 27 kinds of fruits; The unit nutrient contains the lowest calories; it is the best source of vitamin C, and it can be called "the king of fruits and the crown of vitamin C". Kiwifruit contains strong free radical oxidizing substances in the antibody, which can block the formation of carcinogen N-nitrosomol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/48A61P35/00A61P37/02
Inventor 赵正福
Owner 赵正福