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Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof

A rheumatoid and arthritis technology, applied in the field of medical preparations, can solve the problems of endangering the health and quality of life of patients, heavy burdens on society and families, etc., achieve good social value and economic benefits, low treatment costs, and eliminate pain effects

Active Publication Date: 2011-09-14
江西博屾医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, because RA often recurs and persists, it seriously endangers the health and quality of life of patients, and also brings a heavy burden to society and families.

Method used

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  • Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof
  • Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof
  • Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0062] The preparation method of the honey-refined pill of the present invention: firstly extract 1000 g of scorpion and 1000 g of Dilong with ethanol to obtain extract a, and then 1000 g of scorpion, 1000 g of raw rehmannia, 1000 g of astragalus, 1000 g of angelica, 1000 g of drynaria, 1000 g of tuckahoe, and psoralen Fat 1000g, Frankincense 1000g, Chuanxiong 1000g, Dipsacus 1000g, Alisma 1000g, Epimedium 1000g; crushed into coarse powder, then further crushed, sieved through 100-120 mesh sieve, so that the amount of fine powder that can pass through the sieve reaches 30 %, collect the fine powder that passes through the sieve to obtain fine powder b; then put the coarse powder that cannot pass through the 120-mesh sieve into the multi-functional extraction tank for two extractions, add 5-10 times the amount of water for the first time, and cook for 1-2 hours. Add 4-8 times the amount of water twice and cook for 1-2 hours, combine the two decoctions, and filter to obtain the fi...

experiment example 2

[0080] Experimental example 2: Cumulative toxicity test:

[0081] The traditional Chinese medicine preparations of the present invention were taken orally to the mice at 7.69, 19.18 and 43.21g crude drugs / kg for 15 weeks of continuous administration (1.0ml / 100g body weight, twice a day) and 3 weeks after drug withdrawal, the results showed that: the traditional Chinese medicine of the present invention The preparation had no significant effect on the hair, behavior, urine and feces, body weight, organ weight, blood picture, liver and kidney function, blood sugar, blood lipid and other indicators of rats. No abnormal changes were found in the organs by naked eyes. The histological examination results showed that the medication 15 There were no obvious changes in the organs of the rats after weeks and 3 weeks after drug withdrawal. It shows that the oral capsule of the traditional Chinese medicine preparation of the present invention is less toxic to rats after long-term medication...

experiment example 3

[0082] Experimental example 3: Skin irritation test

[0083] The rabbits were shaved, and the topical drug cream was subjected to induction and provocation contact tests. The rabbits were observed 24 hours and 48 hours later, and there was no skin erythema and edema. There was no difference from the negative control group. The results show that the preparation has close to zero skin reaction intensity, that is, no skin allergies. An irritation test was performed on the vagina and broken skin of white mice, and no irritation and other adverse effects were found. The toxicity test proved that the drug has no toxic effects and adverse reactions, and its clinical application is safe and reliable.

[0084] Acute transdermal toxicity test, skin irritation test, skin allergy test, anti-inflammatory test, analgesic test, and microcirculation test were carried out on the external preparation of this drug. The results of the study are as follows:

[0085] 1. Acute dermal toxicity test result...

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Abstract

The invention discloses a Chinese medicine composition for treating rheumatoid arthritis. An oral-taking medicament is prepared from radix angelicae pubescentis, radix rehmanniae, astragalus mongholicus, angelica, rhizoma drynariae, buthus martensi kirsch, tuckahoe, lumbricus, fructus psoraleae, frankincense, ligusticum wallichii, radix dipsaci, rhizoma alismatis and epimedium; an external use medicament is prepared from rhizoma arisaematis, red-rooted salvia root, radix aconiti kusnezoffii praeparata, chinese ephedra, cassia twig, rhizoma typhonii, frankincense, myrrh, ligusticum wallichii, strychnos, radix angelicae, buthus martensi kirsch, dragon's blood, ground beetle, radix dipsaci and rhizoma acori graminei. The Chinese medicine composition is used for treating rheumatoid arthritis, replenishing vital essence and removing heat and dredging meridians by eliminating dampness and has the advantages of convenience for administration, strong target, easiness for preparation, low cost and capability of reaching affected parts. The Chinese medicine composition is scientifically prepared by utilizing medicinal herbs with different drug properties, can achieve ideal treatment effects, is safe and does not have any toxic or side effect; and through the combination of oral taking and external use, the Chinese medicine composition is capable of replenishing vital essence and removing heat, dredging collateral channels by eliminating dampness and eliminating pains.

Description

[0001] Technical field [0002] The invention relates to medical preparations containing components derived from plants, animals or minerals, in particular to a traditional Chinese medicine composition for treating rheumatoid arthritis and a preparation method thereof. Background technique [0003] Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by joint synovitis. Synovitis prolonged and repeated attacks can lead to the destruction of cartilage and bone in the joints, joint dysfunction, and even disability. Vasculitis affects various organs throughout the body, so this disease is also called rheumatoid disease. [0004] Rheumatoid arthritis, also known as rheumatoid arthritis (RA), is a chronic systemic inflammatory disease whose etiology is unknown. The main clinical manifestations are chronic, symmetric, polysynovial arthritis and extra-articular lesions, which are autoimmune Inflammatory diseases. The disease usually occurs in the small joints of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A61K36/889A61K9/06A61P19/02A61P29/00A61K35/64A61K35/62A61K35/646
Inventor 孔建陈守强边晓媛陈延强田林林
Owner 江西博屾医疗器械有限公司
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